Association of Metastasis with Clinicopathological Data in Mexican Patients with Osteosarcoma, Giant Cell Tumor of Bone and Chondrosarcoma

Estrada-Villaseor, E; Escamilla-Uribe, R; P, De la Garza-Montano; R, Dominguez-Rubio; Martinez-Lopez,; Ávila-Luna, Alberto; Alfaro-Rodríguez, Alfonso; Ruvalcaba-Paredes, Erika Karina; Garciadiego-Cázares, David; Bandala, Cindy

doi:10.7314/apjcp.2015.16.17.7689

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…As reported, more than 70% of metastatic sites involve the lung, 7 and pulmonary metastasis significantly reduces patient survival. The 5‐year OS and disease‐free survival after pulmonary metastasis were 30% and 21%, respectively 8 .…”

Section: Introductionmentioning

confidence: 85%

“…Metastasis to the lung is the most common site in patients with osteosarcoma 7 . Many studies have confirmed the negative influence of lung metastasis on the survival of osteosarcoma patients 12,25 .…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis to the lung is the most common site in patients with osteosarcoma. 7 Many studies have confirmed the negative influence of lung metastasis on the survival of osteosarcoma patients. 12,25 In our study, more cases with lung metastasis were found in patients with higher T stage (T2, T3) and N1 stage and those younger than 25 years or older than 60 years.…”

Section: Patterns Of Distant Metastasis In Osteosarcomamentioning

confidence: 99%

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Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Zhang

et al. 2022

Orthopaedic Surgery

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Objective: Based on a large public cohort, we aimed to investigate the prevalence of distant metastases in patients with osteosarcoma, to evaluate the survival of patients with different metastases and to reveal the related risk and prognostic factors for distant metastases. Methods:The information of osteosarcoma patients with or without distant metastases was retrospectively extracted from the Surveillance, Epidemiology, and End Result database from January 2010 to December 2015. Patients were excluded if they were diagnosed at autopsy or via death certification. The Kaplan-Meier method was used to calculate the overall survival in the entire cohort and across patients with metastases to different organs. The related prognostic factors were investigated by univariate and multivariate Cox proportional hazard regression analysis. The logistic regression method was used to reveal the risk factors for the development of different metastases. The effects of different variables on the survival and prevalence of distant metastases were compared using subgroup analysis. Variables with P < 0.05 in the univariate regression analysis were further examined using multivariate regression analysis.Results: In total, 1470 osteosarcoma patients (mean age 30 AE 22 years) were included, among which 278 patients (18.9%) were initially diagnosed with distant metastasis. The median follow-up duration was 33.0 (30.2-35.8) months. The lung was the most common metastatic site (83.8%), followed by the bone (21.9%), liver (2.9%), and brain (2.2%). A total of 232 patients (83.5%) presented only one distant metastatic site, while the other 46 patients showed two or more metastatic sites. A lower proportion of metastasis was observed in patients aged from 25 to 59 years [odds ratio (OR) = 0.59; 95% confidence interval (CI): 0.37-0.95]. More metastases were noted in patients with T2/T1 (

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Section: Introductionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Patterns Of Distant Metastasis In Osteosarcomamentioning

confidence: 99%

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Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Zhang

et al. 2022

Orthopaedic Surgery

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“…Male sex and the site involved (femur and tibia) were confirmed to be associate with greater occurrence of metastasis in a Mexican clinical trial. 7 The primary tumor size was reported to be a risk factor for lung metastasis among patients with osteosarcoma. 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study

Zhang¹,

Guo²,

Xu³

et al. 2019

Sao Paulo Med. J.

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INTRODUCTIONOsteosarcoma is the most prevalent malignant bone tumor in children and adolescents. An overall annual prevalence of 0.2-3 cases per 100,000 population has been reported. 1 Despite the rarity of osteosarcoma, it remains one of the deadliest cancers during the pubertal growth spurt. Lung metastases have been reported to be one of the challenging factors associated with a poor prognosis. 2 Approximately 20% of osteosarcoma patients present with metastatic disease at the time of the initial diagnosis. The most prevalent metastatic type is lung metastasis, which occurs in more than 80% of the cases. 3,4 Despite the development of novel treatments for osteosarcoma, 30-40% of these patients still relapse and the long-term post-relapse survival among these individuals has been reported to be less than 20%. 5,6 Undoubtedly, osteosarcoma patients can benefit from early diagnosis and treatment of metastases. Thus, a reasonable degree of lung metastasis screening for osteosarcoma patients at diagnosis is important. Male sex and the site involved (femur and tibia) were confirmed to be associate with greater occurrence of metastasis in a Mexican clinical trial. 7 The primary tumor size was reported to be a risk factor for lung metastasis among patients with osteosarcoma. 8,9 Currently, radiography is one of the most widely applied clinical screening strategies.However, radiography barely captures metastases until they physically form. Therefore, studies looking into the risk factors for lung metastasis occurrence among patients with osteosarcoma are warranted. ABSTRACT BACKGROUND: Osteosarcoma is the most prevalent malignant bone tumor in children and adolescents. Lung metastases are associated with poor prognosis. OBJECTIVE: The aim here was to explore the prevalence of and risk and prognostic factors for lung metastases in high-grade osteosarcoma patients. DESIGN AND SETTING: Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States. METHODS: Data on 1,408 high-grade osteosarcoma patients registered in the SEER database between 2010 and 2015 were extracted. From these, all patients with high-grade osteosarcoma and initial lung metastasis were selected for analysis on risk and prognostic factors for lung metastases. Overall survival was estimated. RESULTS: There were 238 patients (16.90%) with lung metastases at diagnosis. Axial location, tumor size > 10 cm (odds ratio, OR 3.19; 95% confidence interval, CI: 1.58-6.45), higher N stage (OR 4.84; 95% CI: 1.94-12.13) and presence of bone metastases (OR 8.73; 95% CI: 4.37-17.48) or brain metastases (OR 25.63; 95% CI: 1.55-422.86) were significantly associated with lung metastases. Younger age and surgical treatment (hazard ratio, HR 0.46; 95% CI: 0.30-0.71) favored survival. Median survival was prolonged through primary tumor surgery. CONCLUSIONS:The factors revealed here may guide lung metastasis screening and prophylactic treatment for osteosarcoma patients. A primary tumor in an axial location, greater p...

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“…Distant metastasis can lead to failure of medical therapy and high mortality rate in patients with OS. 16,17 Investigation of the mechanisms underlying the metastasis of OS has been a widely concerned research topic. 18,19 In previous studies, high throughput profiling techniques have been used to identify potential pathways involved in the process of metastasis.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variant of NFIB is Associated With the Metastasis of Osteosarcoma in Chinese Population

Wang

et al. 2019

Technol Cancer Res Treat

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Variant rs7034162 in NFIB was reported to be associated with metastasis of osteosarcoma in European cases with genome-wide significance. Our purpose was to replicate the association of rs7034162 with the metastasis of osteosarcoma in the Chinese population and to further characterize the expression level of NFIB in osteosarcoma tissues. A total of 321 patients were included in this study. Variant rs7034162 was genotyped for each patient using the Taqman genotyping assay. Fifty-two cases of tumor tissues and adjacent normal tissues were collected during surgery. The χ2 test was used to investigate the association of rs7034162 with the metastasis of osteosarcoma. The Student t test was used to compare the gene expression between patients with metastasis and those without metastasis. The messenger RNA expression level of NFIB was then compared among different genotypes of rs7034162 with 1-way analysis of variance test. Ninety-three patients were found to have metastasis. Patients with genotype AA had remarkably higher incidence of metastasis than those with genotype TT (34.4% vs 17.1%, P = .002). Patients with metastasis were found to have significantly higher rate of allele A than those without metastasis (53.2% vs 43.9%, P = .03). The messenger RNA expression of NFIB was significantly lower in tumor tissues of patients with metastasis than in those without metastasis (0.00035 ± 0.00017 vs 0.00063 ± 0.0025, P < .001). Compared to patients with genotype TT, those with genotype AA had remarkably decreased expression of NFIB (0.00033 ± 0.0014 vs 0.00067 ± 0.00037, P = .01). Single-nucleotide polymorphism rs7034162 was associated with metastasis of osteosarcoma in the Chinese population possibly via downregulation of NFIB. Further network analyses revealing the related pathways can help elucidate the molecular mechanism of distant metastasis in patients with osteosarcoma.

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Association of Metastasis with Clinicopathological Data in Mexican Patients with Osteosarcoma, Giant Cell Tumor of Bone and Chondrosarcoma

Cited by 7 publications

References 25 publications

Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study

Genetic Variant of NFIB is Associated With the Metastasis of Osteosarcoma in Chinese Population

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