Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women

Ahmed, Sumia F.; Ali, Mohamed M.; Kheiri, Sumeya; Elzaki, Salah Eldin G.; Adam, Ishag

doi:10.1080/10641955.2020.1725037

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…In this review, the following factors were identified as a risk factors for preeclampsia and eclampsia: paternity [ 25 , 40 ], marital status [ 49 ], HIV/AIDS [ 36 , 41 ], place of residence [ 34 , 40 , 57 ], family size [ 13 , 51 ], maternal sleeping position [ 22 ], blood type [ 45 , 64 ], H. pylori seropositivity [ 16 ], distance from health facility [ 52 ], placental malaria [ 64 ] and seasonal variation [ 19 ]. In addition, recently several researchers investigated the genetic components and related predisposing factors for preeclampsia and eclampsia in African women [ 16 , 20 , 23 , 31 , 33 , 35 , 37 , 43 , 55 , 56 , 59 , 61 – 63 ]. However, this systematic review was not found sufficient evidence to draw strong conclusion to consider them as a risk factor for preeclampsia/eclampsia.…”

Section: Resultsmentioning

confidence: 99%

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

et al. 2020

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Background Preeclampsia and eclampsia are common complications of pregnancy globally, including sub-Saharan African (SSA) countries. Although it has a high burden on maternal and neonatal mortality and morbidity, evidence on the risk of the problem is limited. Therefore, the aim of this review was to examine the factors associated with preeclampsia and eclampsia among mothers in SSA countries. Methods We searched article from SSA countries using electronic database MEDLINE, EMBASE, PubMed, CINAHL published in English from January 2000 to May 2020. Two reviewers independently screened, extracted and assessed the quality of the articles. Both random and fixed effect model were used for analysis. Heterogeneity of the studies and publication bias were checked. STATA 16 used for analysis. Results Fifty-one studies met the inclusion criteria and included in this review. The following factors were identified through meta-analysis: being primiparous (

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Section: Resultsmentioning

confidence: 99%

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

et al. 2020

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“…However, many other studies have reported no association [20,21]. Chromosome 1 contains many loci associated with preeclampsia, namely, MTHFR gene 1p36.3, FV gene 1q23 and LEPR gene 1p31.3 [18,22,23].…”

Section: Introductionmentioning

confidence: 95%

“…To the best of our knowledge, no report has investigated the frequency and association between rs1137101 or rs1805094 and preeclampsia among sub Saharan African patients, including those in Sudan. Therefore, this study investigated the association of rs1137101 and rs1805094 in the development of preeclampsia among Sudanese patients and adds to our previous reports on the genetics of preeclampsia in Sudan [22][23][24].…”

Section: Introductionmentioning

confidence: 97%

Leptin receptor gene polymorphisms c.668A>G and c.1968G>C in Sudanese women with preeclampsia: a case-control study

Saad

Adam

Elzaki³

et al. 2020

BMC Med Genet

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Background: Leptin receptor gene (LEPR) variants may affect the leptin levels and act as a risk factor for preeclampsia. Two LEPR gene missense variants rs1137101 (c.668A>G) and rs1805094 (c.1968G>C) were investigated in Sudanese women with preeclampsia. Methods: A matched case-control study (122 women in each arm) was conducted in Saad Abualila Maternity Hospital in Khartoum, Sudan from May to December 2018. The cases were women with preeclampsia and the controls were healthy pregnant women. Genotyping for LEPR gene variants c.668A>G and c.1968G>C was performed using polymerase chain reaction-restriction fragment length polymorphism. Logistic regression models (adjusted for age, parity, body mass index and hemoglobin level) were conducted. Results: Genotype frequency of LEPR gene variants c.668A>G and c.1968G>C was in accordance with Hardy-Weinberg equilibrium (P > 0.05) in the controls. Allele G in LEPRc.668A>G variant was significantly more frequent in the cases compared with the controls [43.4% vs. 10.2%; OR = 6.44; 95%CI (3.98-10.40); P < 0.001]. In variant LEPRc.668A>G, genotype AG was the prevalent genotype in the cases compared with the controls, and it was significantly associated with preeclampsia risk [37.7% vs. 15.5%; AOR = 3.48; 95%CI (1.15-10.54); P = 0.027]. Likewise, the GG genotype was the second most common genotype in the cases compared with the controls, and was associated with preeclampsia risk [24.6% vs. 2.5%; AOR = 14.19; 95%CI (1.77-113.76); P = 0.012]. None of the LEPRc.1968G>C variant genotypes were associated with preeclampsia. The CC genotype was not detected in neither the cases nor the controls. The haplotype A-G 70.1% was the prevalent haplotype in this population, and it significantly protected against preeclampsia [OR = 0.14; 95%CI (0.09-0.23); P < 0.001]. However, the haplotype G-G 26.8% was significantly associated with preeclampsia risk [OR = 6.70; 95%CI (4.16-11.05); P < 0.001]. Both variants c.668A>G and c.1968G>C were in strong linkage disequilibrium (D′ = 1, r 2 = 0.012). Conclusions: Our data indicate that the rs1137101 (c.668A>G) variant and G-G haplotype may independently associate with the development of preeclampsia.

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“…Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate and one-carbon metabolism, which can catalyze the 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. The 5-methyltetrahydrofolate is the predominant circulatory form of folate and serves as the methyl donor for the re-methylation of homocysteine to methionine, which is the precursor of S-adenosylmethionine (SAMe), the principal biological methyl donor for methylation of DNA [13–18] . Two functional single nucleotide polymorphisms (SNPs) in MTHFR were identified: the MTHFR rs1801133 (C677T) polymorphism (a C to T transition at nucleotide 677 at exon 4, resulting in an alanine-to-valine conversion in protein) and MTFHR rs1801131 (A1298C) polymorphism (a A to C transition at nucleotide 1298 at exon ten, causing a glutamate-to-alanine change in protein) [19,20] .…”

Section: Introductionmentioning

confidence: 99%

Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk

Wang¹,

Ma²,

Guo³

et al. 2021

Medicine

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Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women

Cited by 6 publications

References 43 publications

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

Leptin receptor gene polymorphisms c.668A>G and c.1968G>C in Sudanese women with preeclampsia: a case-control study

Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk

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