Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk

Zhou, Tian-Biao; Li, Hongyan; Xie, Weiji; Zhong, Zhiqing; Zhong, Hao‐Jie; Lin, Zhongxiao

doi:10.1177/1533033819859413

Cited by 12 publications

(10 citation statements)

References 32 publications

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“…Yang et al [19] also indicated that VDR ApaI gene mutation was associated with increased risk and susceptibility to RCC in Chinese Han population. Recently, a meta-analysis [15] obtained similar results with forementioned studies. In current study, we did not find any relationship of FokI, TaqI and BsmI with RCC risk, but we found a significant relation between ApaI and RCC risk.…”

Section: Discussionsupporting

confidence: 72%

“…Such as FokI and BsmI, as defined by the endonucleases FokI and BsmI, respectively, have been most frequently studied in the previous studies. Previously, several studies [13][14][15][16] have been performed to evaluate the association between VDR polymorphisms and RCC risk in different populations, including several meta-analysis studies; however, the results of these studies were conflict. In addition, previous studies have shown that the occurrence and development of RCC is a multi-step, complex and complex process involving multiple environmental factors, genetic factors and the synergy between genetic factors and environmental factors [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk

Jian

Zhang

et al. 2021

Genes and Environ

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Aims We designed a case-control study to investigate the effect of vitamin D receptor gene (VDR) gene single nucleotide polymorphisms (SNPs) and possible gene- environment interaction on the susceptibility of renal cell carcinoma (RCC). Methods Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between SNPs and environmental factors, including gene- gene synergy and gene environment synergy effect. Logistic regression was used to analyze the correlation between the four SNPs in VDR gene and RCC, and the significant interaction combinations found by GMDR model were analyzed by hierarchical analysis. Results The genotype distribution of the control group was in accordance with Hardy- Weinberg equilibrium. Logistic regression analysis showed that the risk of RCC in VDR-rs7975232 A allele carriers was significantly higher than that of CC genotype carriers (CA + AA vs. CC), adjusted OR (95 % CI) = 1.75 (1.26–2.28). We used GMDR model to screen the best synergistic model between the four SNPs of VDR gene and smoking and drinking. We found a significant two locus model (P = 0.0010) involving rs7975232 and smoking. The cross- validation consistency of the two- locus model was 10/ 10, and the accuracy was 60.72 %. Compared with non-smokers with rs7975232 -CA or AA genotype, smokers with rs7975232 -CC genotype had the highest risk of RCC, or (95 % CI) = 2.23 (1.42–3.09), after adjustment for covariates. Conclusions We found that the A allele of rs7975232 within VDR gene, interaction between rs7975232 and smoking were all associated with increased RCC risk.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk

Jian

Zhang

et al. 2021

Genes and Environ

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“…It is of great interest for us to investigate whether IL-16 rs11556218 can serve as practical biomarkers for these types of cancer in Taiwan. As for IL-16 rs4778889, it has been found that the C allele of IL-16 rs4778889 is associated with the risk of renal cell carcinoma (25), especially among Asian ethnicities (26); however, this polymorphic site is not a contributor to oral cancer risk prediction.…”

Section: Discussionmentioning

confidence: 99%

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Shih

Chang

Lee

et al. 2020

In Vivo

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Background/Aim: Interleukin-16 (IL-16) is reported to play an important role in inflammation, carcinogenesis and tumoricidal processes, however, the contribution of IL-16 genotype to oral carcinogenesis is still largely unrevealed. Thus, the study aimed to investigate the contribution of IL-16 genotypes to Taiwan oral cancer risk. Materials and Methods: The genotypes of IL-16 rs4778889, rs11556218, and rs4072111 were revealed among 958 oral cancer cases and 958 control subjects by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: First, the distributions of genotypic (p=0.0004) and allelic (p=0.0001) frequencies of IL-16 rs11556218 were significantly different between the case and control groups. In detail, the frequencies of IL-16 rs11556218 TG and GG were 28.1 and 5.8%, respectively, among oral cancer patients, significantly higher compared to those among controls (25.0% and 2.7%, respectively). Second, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Last, there was a synergistic effect of betel quid chewing behavior and risky IL-16 rs11556218 genotype on oral cancer risk. Conclusion: The study indicates that the IL-16 rs11556218 G allele synergistically interacts with betel quid chewing behavior, contributing to increased risk of oral cancer in Taiwanese. From the viewpoint of epidemiology, oral cancer is the tenth most commonly diagnosed cancer worldwide, with the highest incidence density in Taiwan (1). According to the updated annual report from the Taiwan government, oral cancer is the fourth cause of cancer-related deaths among males in Taiwan and the fifth among all Taiwanese (2). For many years, betel quid chewing habit has been identified as the most effective environmental contributor to oral cancer risk for Taiwanese (3). Although the surgery, therapy and medical caring services for oral cancer have made rapid progress during the past decade, the prevalence and death rate of oral cancer are still very high in Taiwan. Thus, early detection and prediction biomarkers for oral cancer risk are in urgent need. Interleukin-16 (IL-16) is encoded by the IL-16 gene located on chromosome 15q26.3, composed of 631 amino acids and cleaved by caspase 3 to the active IL-16 protein, comprising the 121 amino acid C-terminal (4-6). IL-16 is in charge of activating several types of cells, including CD4+ T cells, monocytes, macrophages, eosinophils, and dendritic cells, and promotes the secretion of inflammatory cytokines, such as IL-1 (7), TNF-, and IL-15 (8). Interestingly, a 1759 This article is freely accessible online.

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“…The genotype of IL-16 rs4778889 was found to be associated with the risk of renal cell carcinoma (42). In the most updated meta-analysis of IL-16 genotype and cancer, the C allele at IL-16 rs4778889 was found to significantly correlate with higher renal cell carcinoma risk, especially among Asian ethnicities (43). Different from those findings mentioned above, genotypes of IL-16 rs11556218 were not associated with the risk of the risk of renal cell carcinoma, and the mechanisms need further validation.…”

Section: Discussionmentioning

confidence: 99%

Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer

Wang

Shen

et al. 2020

In Vivo

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Background/Aim: Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility. Materials and Methods: IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16 rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16 rs11556218 heterozygous variant TG and homozygous variant GG were 36.6 and 7.3% among the lung cancer patients, significantly higher than those among the controls (22.5% and 2.6%). On the other way, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Conclusion: The present study indicates IL-16 rs11556218 G allele is significantly associated with increased Taiwan lung cancer risk.

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Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk

Cited by 12 publications

References 32 publications

Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk

Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer

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