Association of MICA gene polymorphisms with thionamide-induced agranulocytosis

Ma, Pan; Chen, P.; Gao, Jiayi; Guo, Hui; Li, S.; Yang, Jin; Lai, Jianghua; Yang, Xuena; Zhang, Bao; He, Yayi

doi:10.1007/s40618-020-01319-0

Cited by 3 publications

(5 citation statements)

References 26 publications

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“…Robinet et al [32] confirmed that the increased interaction between MICA and NKG2D in galactosaminogalactan-induced neutropenia, leads to NK-cell activation, which in turn generates a Fas-dependent apoptosis-promoting signal in granulocytes. Our previous studies have found an association between the MICA gene and susceptibility to TIA [12,33], and the results of the present study further support the association of NKG2D with TIA. The above results indicate the role of NK cell activity in the mechanism of TIA via the MICA-NKG2D interaction.…”

Section: Case/control Frequenciessupporting

confidence: 90%

“…A recent study on TIA found that genes in HLA-DRB1*08:032 , HLA-DRB1*08:03 , and HLA-B*27:05 were significantly associated with TIA in different populations 7 8 9 10 11 . Our previous study revealed that the major histocompatibility complex class I peptide-related sequence A ( MICA ) gene is associated with susceptibility to TIA in a northern Chinese Han population 12 . MICA potential is one of the natural killer Group 2D (NKG2D) activation receptor ligands, which promotes the activation of natural killer (NK) cells and leads to apoptosis of cells 13 .…”

Section: Introductionmentioning

confidence: 99%

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Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis

He,

Ma,

Luo

et al. 2024

Exp Clin Endocrinol Diabetes

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Objective Antithyroid drug (ATD)-induced agranulocytosis (TIA) is the most serious adverse effect during ATD treatment of Graves’ disease (GD). Previously, the MICA gene was reported to be associated with TIA. MICA protein is an important ligand for the NKG2D protein, which is encoded by the KLRK1 gene and KLRC4-KLRK1 read-through transcription. This study further investigated the association between KLRC4-KLRK1 gene polymorphisms and susceptibility to TIA. Methods Twenty-eight candidate single nucleotide polymorphisms (SNPs) on KLRC4-KLRK1 read-through transcription were evaluated by the iPLEX MassARRAY system in 209 GD control patients and 38 TIA cases. Results A significant association of rs2734565 polymorphism with TIA was found (p=0.02, OR=1.80, 95% CI=1.09–2.96). The haplotype C-A-A-C-G, including rs2734565-C, was associated with a significantly higher risk of TIA (p=4.79E-09, OR=8.361, 95% CI=3.737–18.707). In addition, the interval time from hyperthyroidism to agranulocytosis onset was shorter in patients carrying the rs2734565-C allele than in non-carrying groups (45.00 (14.00–6570.00) d vs. 1080.00 (30.00–3600.00) d, p=0.046), and the interval from ATD treatment to agranulocytosis onset was also shorter in patients carrying rs2734565-C allele (29.00 (13.00–75.00) d vs. 57.50 (21.00–240.00) d, p=0.023). Conclusions The findings suggest that the KLRC4-KLRK1 gene polymorphism is associated with susceptibility and progression of ATD-induced agranulocytosis. Patients carrying the rs2734565-C allele had a higher susceptibility and faster onset time of TIA.

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Section: Case/control Frequenciessupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis

He,

Ma,

Luo

et al. 2024

Exp Clin Endocrinol Diabetes

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“…Recent genetic studies have identified the close genetic susceptibility of ATD‐induced agranulocytosis, namely, thionamide‐induced agranulocytosis (TIA), in various ethnic groups, especially those genes that encode the major HLAs with alleles HLA‐B*38:02, HLA‐B*27:05, and HLA‐DRB1*08:03 4–8 . We revealed that six single nucleotide polymorphisms (SNPs) of MICA gene (rs116666910, rs145575084, rs116135464, rs189600525, rs148015908, and rs4349859) and HLA‐B*27:05 exhibited significant associations with the susceptibility of TIA in Chinese Han population in our previous study 9 …”

Section: Introductionmentioning

confidence: 75%

“…Second, allele frequencies of MICA‐129 were tested for Hardy–Weinberg equilibrium (HWE), and the association with TIA was tested by χ 2 using Plink software. In addition, combined with our previous HLA data and published SNPs (rs116666910, rs145575084, rs116135464, rs189600525, rs148015908, and rs4349859) data, 9 haplotype analysis of MICA‐129 , HLA‐B and six SNP polymorphisms was conducted for both TIA and GD control groups using the χ 2 test using Haploview 4.2 software (http://www.broadinstitute.org/haploview). Differences with p values of < .05 were considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

“…[4][5][6][7][8] We revealed that six single nucleotide polymorphisms (SNPs) of MICA gene (rs116666910, rs145575084, rs116135464, rs189600525, rs148015908, and rs4349859) and HLA-B*27:05 exhibited significant associations with the susceptibility of TIA in Chinese Han population in our previous study. 9 Non-HLA genes also cause numerous drug-induced adverse effects through various pharmacokinetic and pharmacodynamic mechanisms. 8 Genome-wide association studies (GWAS) in the European population and our unpublished data showed that some SNPs in or near the MHC Class I Polypeptide-Related Sequence A (MICA) gene are associated with TIA.…”

Section: Introductionmentioning

confidence: 99%

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MICA polymorphisms associated with antithyroid drug‐induced agranulocytosis in the Chinese Han population

Gong

Chen

et al. 2020

Immunity Inflam & Disease

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Background Graves' disease (GD) is a clinical autoimmune thyroid disease. During the treatment of GD, antithyroid drug‐induced agranulocytosis (TIA) is a common and even life‐threatening adverse drug reaction. Previous studies suggested that susceptibility to TIA is strongly associated with HLA‐B*27:05, HLA‐B*38:02, and HLA‐DRB1*08:03 genetic variation and six single nucleotide polymorphisms (SNPs) in MICA genes. Aims The purpose of this study is to further study the associations between TIA, HLA‐B and MICA. Materials & Methods We genotyped MICA‐STR and MICA‐129 variants in 41 TIA and 308 control patients with GD and investigated the linkage effect among SNPs and short tandem repeat (STR) of MICA and HLA‐B alleles. Results The results showed that MICA*A5.1 was significantly associated with TIA (p = .007, odd ratio = 1.958, 95% confidence interval, 1.192–3.214). In addition, high linkage among MICA‐129 and six SNPs MICA and HLA‐B was detected, and two haplotypes (AAAACAAAAACGGCCTA and AACAAAAAAAACATTAA (p = 5.14E−07 and p = 3.42E−08, respectively)) were significantly associated with TIA. Furthermore, when we analyzed only MICA‐129 and HLA‐B separately, the haplotypes (AAAACAAAAAA with p = 2.49E−07 and AACAAAAAAAA with p = 2.14E−09) were identified with more significant effects. MICA‐129 was completely linked to six SNPs with haplotypes ACATTACA (p = 2.05E−05) significantly associated with TIA. Conclusion These data indicated that there was a significant linkage effect between MICA‐129 and other alleles, suggesting that they exert interactive effects as risk factors for the development of TIA.

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Thyroid hormones, iodine, and iodides, and antithyroid drugs

Schalliol

Pittman²

2022

Side Effects of Drugs Annual

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Association of MICA gene polymorphisms with thionamide-induced agranulocytosis

Cited by 3 publications

References 26 publications

Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis

Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis

MICA polymorphisms associated with antithyroid drug‐induced agranulocytosis in the Chinese Han population

Thyroid hormones, iodine, and iodides, and antithyroid drugs

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