Association of microRNA-related gene XPO5 rs11077 polymorphism with susceptibility to thyroid cancer

Wen, Jing; Qingjun, Gao; Wang, Nanpeng; Zhang, Wei; Cao, Kun; Qiang, Zhang; Chen, Shi; Shi, Lei

doi:10.1097/md.0000000000006351

Cited by 28 publications

(26 citation statements)

References 31 publications

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“…As XPO5 is a key factor for the transportation of miRNA from the nucleolus, it has been postulated as a rate-limiting step in the development of miRNAs, so its impairment could lead to pre-miRNA trapping in the nucleolus, influencing the risk of cancer [60][61]. Current studies have indicated the role of XPO5 in the development of several sorts of cancers such as hepatocellular carcinoma, thyroid cancer, lung cancer, and so on [62][63][64]. These studies are consistent with the results of the present study in which XPO5 mRNA expression levels were significantly increased in tumor tissues compared to normal tissues in 154 paired cancer tissue samples from the TCGA database.…”

Section: Discussionmentioning

confidence: 99%

Association of microRNA biosynthesis genes XPO5 and RAN polymorphisms with cancer susceptibility: Bayesian hierarchical meta-analysis

Shao¹,

Shen²,

Zhao³

et al. 2020

J. Cancer

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XPO5/RAN-GTP complex mediates the nuclear transport of pre-miRNAs in the miRNA processing system, its altered expression is indicated to be correlated with cancer risk. Several studies have inspected the association between XPO5 or RAN polymorphisms and the risk of various cancers, but the findings remain controversial. A Bayesian hierarchical meta-analysis was carried out to review and analyze the effect of XPO5 and RAN polymorphisms on cancer risk. The association was estimated by calculating the logarithm of odds ratio (Log OR) and 95% credible interval (95% CrI). The expression quantitative trait loci (eQTL) analysis was used for in silico functional validation of the identified significant susceptibility loci. Consequently, 38 case-control studies (from 27 citations) with 27,459 cancer cases and 25,151controls were included in the meta-analysis of the five most prevalent SNPs (rs11077 A/C, rs2257082 G/A, rs3803012 A/G, rs14035 C/T, rs3809142 C/T). In the XPO5 gene rs11077 SNP, the minor C allele significantly increased the risk of cancer (Log OR = 0.120, 95% CrI = 0.013, 0.241), and a strong association between rs11077 SNP and cancer risk was also found in the dominant model (CC + AC vs. AA: Log OR = 0.132, 95% CrI = 0.009, 0.275). In addition, the minor GG genotype allele of the RAN gene rs3803012 SNP significantly increased the cancer risk (Log OR = 0.707, 95% CrI = 0.059, 1.385). Statistically significant associations between rs3803012 SNP and cancer risk were also observed in the recessive model (GG vs. AG + AA: Log OR = 0.708, 95% CrI = 0.059, 1.359). Furthermore, the eQTL analysis revealed that rs11077 SNP was significantly correlated with XPO5 mRNA expression, which provided additional biological basis for the observed positive association. Our results suggest that XPO5 rs11077 may be a possible functional susceptibility locus for cancer risk.

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Section: Discussionmentioning

confidence: 99%

Association of microRNA biosynthesis genes XPO5 and RAN polymorphisms with cancer susceptibility: Bayesian hierarchical meta-analysis

Shao¹,

Shen²,

Zhao³

et al. 2020

J. Cancer

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show abstract

“…The XPO5 gene has been found to play a role in carcinogenesis, as it was reported that certain cancers (e.g., non-small-cell lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, and thyroid cancer) express levels of XPO5 that are distinct from those detected in normal cells [43,44,45,46,47,48]. In particular, a number of studies have reported that XPO5 polymorphisms at the rs11077 locus affect disease development and patient survival in various cancers.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Association Between MicroRNA Biogenesis Gene Polymorphisms and Venous Thromboembolism in Koreans

Kim

et al. 2019

IJMS

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Venous thromboembolism (VTE) involves the formation of a blood clot, typically in the deep veins of the leg or arm (deep vein thrombosis), which then travels via the circulatory system and ultimately lodges in the lungs, resulting in pulmonary embolism. A number of microRNAs (miRNAs) are well-known regulators of thrombosis and thrombolysis, and mutations in miRNA biogenesis genes, such as DICER1, DROSHA have been implicated in miRNA synthesis and function. We investigated the genetic association between polymorphisms in four miRNA biogenesis genes, DICER1 rs3742330A > G, DROSHA rs10719T > C, RAN rs14035C > T and XPO5 rs11077A > C, and VTE in 503 Koreans: 300 controls and 203 patients. Genotyping was assessed with polymerase chain reaction-restriction fragment length polymorphism assays. We detected associations between polymorphisms in RAN and XPO5 and VTE prevalence (RAN rs14035CC + CT versus TT: p = 0.018; XPO5 rs11077AA + AC versus CC: p < 0.001). Analysis of allele combinations of all four polymorphisms (DICER1, DROSHA, RAN, XPO5) revealed that A-T-T-A was associated with decreased VTE prevalence (p = 0.0002), and A-T-C-C was associated with increased VTE prevalence (p = 0.027). Moreover, in subjects with provoked VTE, the DROSHA rs10719T > C, polymorphism was associated with increased disease prevalence (TT versus TC + CC: p < 0.039). Our study demonstrates that RAN and XPO5 polymorphisms are associated with risk for VTE in Korean subjects.

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“…These results suggest that the XPO5 miRNA-SNP, rs11077, is a potential biomarker for thyroid cancer prediction, via its functional impact upon XPO5 expression [65]; however, there is no report of a functional connection between XPO5 and thyroid cancer incidence.…”

Section: Significance Of Microrna Polymorphisms In Nmtcmentioning

confidence: 99%

Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer

Hińcza¹,

Kowalik²,

Kowalska

2019

Genes

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The thyroid is the most common site of endocrine cancer. One type of thyroid cancer, non-medullary thyroid cancer (NMTC), develops from follicular cells and represents approximately 90% of all thyroid cancers. Approximately 5%–15% of NMTC cases are thought to be of familial origin (FNMTC), which is defined as the occurrence of the disease in three or more first-degree relatives of the patient. It is often divided into two groups: Syndrome-associated and non-syndromic. The associated syndromes include Cowden syndrome, familial adenomatous polyposis, Gardner syndrome, Carney complex and Werner syndrome. The hereditary factors contributing to the unfavorable course of FNMTC remain poorly understood; therefore, considerable effort is being expended to identify contributing loci. Research carried out to date identifies fourteen genes (DICER1, FOXE1, PTCSC2, MYH9, SRGAP1, HABP2, BRCA1, CHEK2, ATM, RASAL1, SRRM2, XRCC1, TITF-1/NKX2.1, PTCSC3) associated with vulnerability to FNMTC that are not related to hereditary syndromes. In this review, we summarize FNMTC studies to date, and provide information on genes involved in the development of non-syndromic familial non-medullary thyroid cancers, and the significance of mutations in these genes as risk factors. Moreover, we discuss whether the genetic polymorphism rs966423 in DIRC3 has any potential as a prognostic factor of papillary thyroid cancer.

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Association of microRNA-related gene XPO5 rs11077 polymorphism with susceptibility to thyroid cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 28 publications

References 31 publications

Association of microRNA biosynthesis genes XPO5 and RAN polymorphisms with cancer susceptibility: Bayesian hierarchical meta-analysis

Association of microRNA biosynthesis genes XPO5 and RAN polymorphisms with cancer susceptibility: Bayesian hierarchical meta-analysis

Analysis of the Association Between MicroRNA Biogenesis Gene Polymorphisms and Venous Thromboembolism in Koreans

Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer

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