Association of miR-146a rs2910164 and miR-149 rs2292832 Variants with Susceptibility to Type 2 Diabetes

Alipoor, Behnam; Meshkani, Reza; Ghaedi, Hamid; Sharifi, Zohreh; Panahi, Ghodratollah; Golmohammadi, Taghi

doi:10.7754/clin.lab.2016.160124

Cited by 27 publications

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“…They primarily target IL receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) to modulate and prevent overstimulation of inflammatory responses in the TLR/NF-κB pathways [ 11 ]. The miR-146a G/C SNP (due to a C:U miss-pairing taking place instead of a normal G:U pairing), contributes towards the pathogenesis of several inflammatory diseases, including autoimmune disorders [ 12 ], sepsis [ 13 ], cardiovascular disease [ 14 ] and diabetes [ 15 ]. This SNP is situated within the crucial stem region of pre-miRNA-146a and affects the expression of mature miR-146a [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

et al. 2018

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BackgroundPsoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA. In South Africa, psoriasis and PsA are extremely rare in the indigenous African population and most common in both the Indian and Caucasian population. The aim of this study was to investigate whether the miR-146a rs2910164 contributes towards psoriasis and PsA development in South African Indian and Caucasian patients.MethodsSouth African Indian (n = 84) and Caucasian (n = 32) PsA patients (total n = 116) and healthy control subjects (Indian: n = 62 and Caucasian: n = 38; total n = 100) were recruited in the study. DNA was extracted from whole blood taken from all subjects, and genotyped for the miR-146a rs2910164 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data for laboratory parameters were obtained from pathology reports. The consulting rheumatologist collected all other clinical data.ResultsUnstratified data (Caucasians + Indians): A significant decrease in C-reactive protein (CRP) levels in PsA patients was observed (CRP monitored at inclusion vs. after 6 months of treatment) (18.95 ± 2.81 mg/L vs. 9.68 ± 1.32 mg/L, p = 0.0011). The miR-146a rs2910164 variant C-allele frequency in PsA patients was significantly higher vs. healthy controls (35.78% vs. 26% respectively, p = 0.0295, OR = 1.59 95% CI 1.05–2.40). Stratified data (Indians): The variant C-allele frequency in Indian PsA patients was significantly higher vs. healthy Indian controls (35.71% vs. 22.58%, p = 0.0200, OR = 1.91 95% CI 1.13–3.22). Stratified data (Caucasians): The variant C-allele frequency distribution between Caucasian PsA patients and healthy Caucasian controls was similar.ConclusionThe rs2910164 variant C-allele may play a role in the progression of PsA in the South African Indian population. The main limitation in this study was the small sample size in the case-control cohorts, with a low overall statistical power (post-hoc power analysis = 19%).

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Section: Introductionmentioning

confidence: 99%

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

et al. 2018

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“…miR-149 has been extensively studied in tumor biology, and was demonstrated to be involved in different processes of tumorigenesis and development, including proliferation, migration, invasion and epithelial-mesenchymal transition (22,23). In addition, miR-149 serves important roles in a number of other diseases, including stroke, type II diabetes and non-alcoholic fatty liver disease (24)(25)(26)(27)(28). A recent study reported that the circulating level of miR-149 decreased in mouse models with severe heart failure (29).…”

Section: Discussionmentioning

confidence: 99%

miR‑149 promotes the myocardial differentiation of mouse bone marrow stem cells by targeting Dab2

Wang

et al. 2018

Mol Med Report

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To investigate the role of microRNA (miR)‑149 in the cardiac differentiation of mouse bone marrow mesenchymal stem cells (MSCs) in vitro, MSCs were infected with a lentivirus overexpressing miR‑149 and the effect on cardiac differentiation was determined. The quantitative polymerase chain reaction results demonstrated that miR‑149 promoted the expression of cardiac‑specific markers in MSCs. Western blotting and a luciferase activity assay demonstrated that disabled homolog 2 (Dab2) was a direct target of miR‑149. Dab2 ectopic expression and Wnt/β‑catenin signaling pathway inhibition was able to reverse the increased expression of cardiac‑specific markers induced by miR‑149. In conclusion, miR‑149 was able to target Dab2 and promote the cardiac differentiation of mouse MSCs in vitro, which depended upon the Wnt/β‑catenin signaling pathway.

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“…To determine the potential relationship between miRNA SNPs and EGJA risk, we selected the miRNA-146a rs2910164 C>G polymorphism according to the literature, which was significantly associated with cancer, 27 , 28 type 2 diabetes, 29 , 30 autoimmune diseases, 31 – 33 and coronary artery disease 34 , 35 in some studies. The corresponding information about the miRNA-146a rs2910164 C>G polymorphism is presented in Table 2 .…”

Section: Methodsmentioning

confidence: 99%

miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case–control study involving 2,740 participants

Chen

Tang

Liu

et al. 2018

CMAR

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PurposeThe miRNA-146a rs2910164 C>G polymorphism may contribute to the development of cancer. However, the association between this polymorphism and the risk of esophagogastric junction adenocarcinoma (EGJA) remains unclear. In the present study, we carried out a case–control study to explore the potential relationship between miRNA-146a rs2910164 C>G polymorphism and EGJA risk.Patients and methodsIn total, 1,063 EGJA patients and 1,677 cancer-free controls were enrolled. The SNPscan™ genotyping assay, a patented technology, was used to test the genotyping of miRNA-146a rs2910164 C>G polymorphism.ResultsWe found that miRNA-146a rs2910164 C>G polymorphism was associated with a risk of developing EGJA (additive model: adjusted odds ratio (OR), 1.27; 95% CI, 1.07–1.51; P=0.006; homozygote model: adjusted OR, 1.31; 95% CI, 1.03–1.65; P=0.027 and dominant model: adjusted OR, 1.36; 95% CI, 1.15–1.60; P<0.001). After adjustment for the Bonferroni correction, these associations were also found in additive and dominant genetic models. In the subgroup analyses, after adjustment by sex, age, alcohol consumption, and smoking status, results of multiple logistic regression analysis indicated that miRNA-146a rs2910164 C>G polymorphism increased the risk of EGJA in males, females, <64 years old, ≥64 years old, never smoking, and never drinking subgroups.ConclusionThe current study highlights that the miRNA-146a rs2910164 C>G polymorphism increased the risk of EGJA in eastern Chinese Han population.

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Association of miR-146a rs2910164 and miR-149 rs2292832 Variants with Susceptibility to Type 2 Diabetes

Abstract: Our findings suggest that miR-146a rs2910164 polymorphism might be associated with T2D and its cardiovascular risk factors in an Iranian population.

Cited by 27 publications

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MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

miR‑149 promotes the myocardial differentiation of mouse bone marrow stem cells by targeting Dab2

miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case–control study involving 2,740 participants

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Association of miR-146a rs2910164 and miR-149 rs2292832 Variants with Susceptibility to Type 2 Diabetes

Abstract: Our findings suggest that miR-146a rs2910164 polymorphism might be associated with T2D and its cardiovascular risk factors in an Iranian population.

Cited by 27 publications

References 0 publications

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

miR‑149 promotes the myocardial differentiation of mouse bone marrow stem cells by targeting Dab2

miRNA-146a rs2910164 C&gt;G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case&ndash;control study involving 2,740 participants

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miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case–control study involving 2,740 participants