Association of MIR3117 and MIR612 Genes Polymorphisms with Childhood Acute Lymphoblastic Leukemia in the Mexican Population

Ayón‐Pérez, Miriam Fabiola; Gómez‐Gómez, Yazmín; Organista‐Nava, Jorge; Leyva‐Vázquez, Marco Antonio; Zambrano‐Zaragoza, José Francisco; Reyes-Fregoso, Julio César; Agraz‐Cibrián, Juan Manuel; Gutiérrez‐Franco, Jorge; Santos, Marcelo Victorio-De los; Vázquez‐Reyes, Alejandro

doi:10.1016/j.arcmed.2022.07.004

Cited by 2 publications

(3 citation statements)

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“…Haplotype analysis did not reveal any statistically signi cant differences in the two SNPs analyzed in the miR-3117 gene. These ndings are consistent with those reported in breast cancer [29].…”

Section: Discussionsupporting

confidence: 93%

“…Nevertheless, the role of miR-3117 in tumor progression remains to be elucidated. The studies that have been conducted on the SNPs rs7512692 and rs4655646 of the miR-3117 gene have been relatively limited in scope and have primarily focused on analyzing the risk associated with these variants in breast cancer [29]. This is the rst study to analyze these variants in CRC.…”

Section: Discussionmentioning

confidence: 99%

“…Alterations in this pathway have been described in several types of cancer, including colorectal cancer [26,27]. The role of the rs7512692 and rs4655646 polymorphisms with respect to the miRNA-3117 in cancer has only been investigated in acute lymphoblastic leukemia [25,28] and breast cancer [29]. In CRC, these variants have not been analyzed.…”

Section: Introductionmentioning

confidence: 99%

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Impact of the HOTAIR (rs920778) and miR-3117 (rs7512692) variants on the Susceptibility and Clinicopathologic characteristics of patients with colorectal cancer

Trujillo-Fernández,

Rodríguez-Torres,

Tovar-Jacome

et al. 2024

Preprint

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Background: Colorectal cancer (CRC) is the most common type of gastrointestinal cancer. Genetic, epigenetic, and lifestyle factors have been implicated in the development of CRC. Non-coding RNAs such as HOX transcript antisense RNA (HOTAIR) and miR-3117genes have been associated with cell proliferation, progression, invasion, and metastasis as well as poor survival in several cancers. This study examines the potential association between the HOTAIR rs920778 and miR-3117variants and the clinicopathological features of CRC in Mexican patients. Methods: The study included peripheral blood samples from 588 individuals (289 CRC patients and 299 controls). The variants were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The association was calculated using the odds ratio (OR) test. P-values were adjusted using the Bonferroni test (0.016). Results: Individuals carrying the T/C and T/T genotypes for the HOTAIR rs920778 variant exhibited a higher susceptibility to CRC (OR=1.73, 95% CI: 1.15-2.58, P=0.009 and OR=2.78, 95% CI: 1.74-4.45, P=0.001, respectively). Male patients older than 50 years and carrying the C/C genotype demonstrated an increased susceptibility for developing CRC (OR=1.73, 95% CI: 1.15-2.58, P=0.009). Additionally, C/C genotype carriers exhibited an association with advanced TNM stage. Furthermore, for the rs7512692 variant of the miR-3117 gene, patients carrying the C/T genotype exhibited increased susceptibility for developing CRC (OR=1.92, 95% CI: 1.35-2.74, P=0.001). Male patients over 50 years of age and carrying the C/T genotype demonstrated increased susceptibility for early TNM stages and tumor location in the colon. Conclusion: The results obtained suggest that the HOTAIR rs920778 and miR-3117rs7512692 variants play a significant role in colorectal cancer risk.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%