Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study

Djurić, Tamara; Stanković, Aleksandra; Končar, Igor; Radak, Djordje; Davidović, Lazar; Alavantić, Dragan; Živković, Maja

doi:10.1016/j.atherosclerosis.2011.08.025

Cited by 25 publications

(19 citation statements)

References 25 publications

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“…In another study the significantly higher frequency of the −381 G allele was found in female patients with carotid atherosclerosis compared to controls [139]. The significantly higher expression of MMP-8 mRNA was found in carotid plaques of the G−381 T−799 haplotype compared to the reference A-381C−799 haplotype [139].…”

Section: Mmp-8mentioning

confidence: 87%

Overview of MMP Biology and Gene Associations in Human Diseases

Djurić¹,

Živković²

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Interactions of cell with the extracellular matrix (ECM) are crucial for normal development and functioning of the human organism. By regulating ECM integrity and composition matrix metalloproteinases (MMPs) play the main role in ECM molecules signaling and influence processes such as proliferation, migration, differentiation and apoptosis.ECM remodeling is a highly regulated process. When imbalanced it could contribute to pathophysiology of many diseases. The MMPs actions and activity are regulated through different mechanisms such as regulation of transcription, activation of latent MMPs, inhibition of MMP function by tissue inhibitors of metalloproteinases. MMPs are a family of calcium-and zinc-dependent endoproteinase, which share similar structural domains, but differs in substrate specificity, cell localizations and inducibility. Genetic variations in MMPs have been associated with a number of diseases, still not all findings are reproducible. Nine of 23 human genes encoding MMPs are located in a cluster on chromosome 11, which implicate their haplotype-driven effects. They could be important mediators of disease severity and could trigger acute events. In this chapter, we will review the basics of MMP biology and the most significant associations of MMPs variations with cardiovascular and neurological diseases in humans and MMPs therapeutic potential through synthetic inhibitors.

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Section: Mmp-8mentioning

confidence: 87%

Overview of MMP Biology and Gene Associations in Human Diseases

Djurić¹,

Živković²

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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“…Moreover, an association between MMP8 gene variation and extent of coronary and carotid atherosclerosis [81,82] was observed. Significant upregulation of MMP-8 gene expression in carotid plaque tissue was observed in patients carrying haplotype G(-381)T(-799) of two MMP-8 promoter polymorphisms rs11225395 (-799 C/T) and rs1320632 (-381 A/G) [82]. Recently, it was shown that Ang II treatment in vitro causes increased collagen I synthesis and galectin-3 (Gal-3) expression in mouse HL-1 cardiomyocytes via protein kinase Calpha (PKC-α) pathway [83].…”

Section: Role Of Ras In Atherosclerosis Progression and Acute Complicmentioning

confidence: 91%

“…Laxton et al demonstrated in vitro that MMP-8 cleaves Ang I to generate Ang II, and that MMP8-knockout mice have a substantial reduction in formation of atherosclerotic lesions [81]. Moreover, an association between MMP8 gene variation and extent of coronary and carotid atherosclerosis [81,82] was observed. Significant upregulation of MMP-8 gene expression in carotid plaque tissue was observed in patients carrying haplotype G(-381)T(-799) of two MMP-8 promoter polymorphisms rs11225395 (-799 C/T) and rs1320632 (-381 A/G) [82].…”

Section: Role Of Ras In Atherosclerosis Progression and Acute Complicmentioning

confidence: 99%

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Kolaković¹,

Živković²,

Stanković³

2017

Renin-Angiotensin System - Past, Present and Future

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The renin-angiotensin system (RAS) is a well known for its role in the regulation of the blood pressure (BP). Angiotensin II (Ang II), the main mediator of the RAS, may act either, as a systemic molecule or a locally produced factor. Within the vessel wall it has significant proinflammatory role by inducing the oxidative stress, secretion of inflammatory cytokines and adhesion molecules. Ang II could trigger proliferation of vascular smooth muscle cells (VSMC) and its migration to the outer layer of the vessel wall. It could induce the release of matrix metalloproteinase (MMPs), from human VSMC and thus increase susceptibility to rupture of atherosclerotic lesions. Binding of Ang II to AT1R/AT2R could have opposing actions in vascular injury. The ACE2/Ang (1-7)/Mas axis of the RAS also opposes the unfavourable actions of ACE/Ang II/ATR1 axis. Inhibition of RAS could reduce inflammation-associated processes in vasculature, independently of lowering BP. RAS is significantly modulated by the genes coding for this system. Certain genetic variants (SNPs) in the RAS genes have been denoted as the functional ones and have been associated with hypertension, cardiovascular phenotypes and atherosclerosis. Also, the genetic components of the RAS interfere with the regulators of gene expression by microRNAs (miRs).

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Section: Association Of Matrix Metalloproteinase-8 Genetic Variation mentioning

confidence: 99%

“…Djurić et al examined the MMP8 promoter SNP rs11225395 (−799C N T) and rs1320632 (−381A N G) in a group of patients with carotid atherosclerosis undergoing endarterectomy and individuals without evidence of carotid atherosclerosis (Djuric et al, 2011). Their study showed that compared with the C −799 A −381 haplotype, the T −799 G −381 haplotype was associated with higher MMP8 expression levels in carotid plaques, and that the T −799 G −381 haplotype had a higher frequency in female cases (n = 176) than in female controls (n = 135) (Djuric et al, 2011). Similarly, Pradhan-Palikhe et al tested these two MMP8 promoter SNPs in a study of 124 patients with arterial disease and 100 healthy blood donors, and observed an association of the T −799 allele with higher serum MMP8 levels and a higher frequency of this allele in the case group than in the control group (Pradhan-Palikhe et al, 2012).…”

Section: Association Of Matrix Metalloproteinase-8 Genetic Variation mentioning

confidence: 99%

Putative targeting of matrix metalloproteinase-8 in atherosclerosis

2015

Pharmacology & Therapeutics

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Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study

Cited by 25 publications

References 25 publications

Overview of MMP Biology and Gene Associations in Human Diseases

Overview of MMP Biology and Gene Associations in Human Diseases

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Putative targeting of matrix metalloproteinase-8 in atherosclerosis

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