Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

Kim, Jee Wook; Byun, Min Soo; Yi, Dahyun; Lee, Jun Ho; Ko, Kang; Jeon, So Yeon; Sohn, Bo Kyung; Lee, Jun-Young; Kim, Yu Kyeong; Shin, Seong A.; Sohn, Chul‐Ho; Lee, Dong Hoon

doi:10.1371/journal.pmed.1003022

Cited by 34 publications

(27 citation statements)

References 55 publications

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“…Our failure to observe significant differences in both global and regional [ 11 C]PiB SUVR values between AUD and HC subjects is consistent with and extends earlier reports showing no elevation in Aβ accumulation in heavy drinkers compared to their abstinent counterparts 8 , as well as with previous post-mortem data that found no significant elevation in aggregation of Aβ in alcohol abusing individuals compared to HCs 6 . The cortical thinning and loss of hippocampal GMV observed in this study are also consistent with previous research in subjects with AUD [40][41][42][43][44] and of a magnitude such that they are likely clinically significant.…”

Section: Discussionsupporting

confidence: 92%

“…Given the retrospective nature of this study, a number of potential confounding variables may have been present (e.g., survivor bias, psychiatric and medical comorbidities, periods of abstinence from alcohol, and comorbid use of other substances), which complicates the interpretation of these data 7 . Another recent study, in which 414 community members (age 70.9 ± 7.8 years), all without dementia or alcohol-related disorders, underwent carbon-11-labeled Pittsburgh Compound-B ([ 11 C]PiB) positron emission tomography (PET) imaging, found no elevation in Aβ accumulation in heavy drinkers (>14 drinks per week) compared to their abstinent counterparts 8 . However, given that the presence of any alcohol-related disorder was an exclusion criterion for this study, it is difficult to extend the interpretation of these findings to individuals with AUD.…”

Section: Introductionmentioning

confidence: 99%

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Imaging beta-amyloid (Aβ) burden in the brains of middle-aged individuals with alcohol-use disorders: a [11C]PIB PET study

et al. 2021

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No in vivo human studies have examined the prevalence of Alzheimer’s disease (AD) neuropathology in individuals with alcohol-use disorder (AUD), although recent research suggests that a relationship between the two exists. Therefore, this study used Pittsburgh Compound-B ([11C]PiB) PET imaging to test the hypothesis that AUD is associated with greater brain amyloid (Aβ) burden in middle-aged adults compared to healthy controls. Twenty healthy participants (14M and 6F) and 19 individuals with AUD (15M and 4F), all aged 40–65 years, underwent clinical assessment, MRI, neurocognitive testing, and positron emission tomography (PET) imaging. Global [11C]PiB standard uptake value ratios (SUVRs), cortical thickness, gray matter volumes (GMVs), and neurocognitive function in subjects with AUD were compared to healthy controls. These measures were selected because they are considered markers of risk for future AD and other types of neurocognitive dysfunction. The results of this study showed no significant differences in % global Aβ positivity or subthreshold Aβ loads between AUD and controls. However, relative to controls, we observed a significant 6.1% lower cortical thickness in both AD-signature regions and in regions not typically associated with AD, lower GMV in the hippocampus, and lower performance on tests of attention as well as immediate and delayed memory in individuals with AUD. This suggest that Aβ accumulation is not greater in middle-aged individuals with AUD. However, other markers of neurodegeneration, such as impaired memory, cortical thinning, and reduced hippocampal GMV, are present. Further studies are needed to elucidate the patterns and temporal staging of AUD-related pathophysiology and cognitive impairment. Imaging β-amyloid in middle age alcoholics as a mechanism that increases their risk for Alzheimer’s disease; Registration Number: NCT03746366.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Imaging beta-amyloid (Aβ) burden in the brains of middle-aged individuals with alcohol-use disorders: a [11C]PIB PET study

et al. 2021

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“…Upon admission, a standardized questionnaire was used to collect detailed information about each patient's demographic and medical history, including age, gender, education level, smoking history, drinking history, hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, history of stroke, and treatment of stenosis (thrombolysis/thrombectomy/stents implantation). In our study, drinking history and smoking history were binary variables, no-smoker, and no drinking were regard as no smoking and drinking history, others were considered to have smoking and drinking history (17,18). The National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI), Modified Rankin scale (MRS), Social Support Rating Scale (SSRS), and the 17-item Hamilton Rating Scale for Depression (HAMD-17) were evaluated by two qualified and formally trained doctors (X.S.…”

Section: Data Collectionmentioning

confidence: 99%

Association of Cerebral Artery Stenosis With Post-stroke Depression at Discharge and 3 Months After Ischemic Stroke Onset

et al. 2020

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Background: Post-stroke depression (PSD) is one of the most common complications after stroke, which seriously affects patients' recovery outcome. Although vascular depression has been extensively studied, the relationship between cerebral artery stenosis and PSD has not been clarified so far.Methods: Two hundred ninety-eight patients with ischemic stroke (72 women, 226 men) with computed tomography angiography (CTA) or magnetic resonance angiography (MRA) were included in this study. Cerebral artery stenosis ≥50% was used as the cut-off value. The DSM-V diagnostic criteria of PSD was met and the 17-item Hamilton Rating Scale for Depression (HAMD-17) score over 7 at discharge and 3 months after stroke onset was regarded as the primary outcome. The χ2-test, Mann-Whitney U-test, and t-test were used to check for statistical significance.Results: At discharge, Barthel index (p < 0.001), left middle cerebral artery stenosis (p = 0.019), drinking history (p = 0.048), basilar artery stenosis (p = 0.037) were significantly associated with PSD. At 3 months after ischemic stroke onset, Barthel index (p = 0.011), left middle cerebral artery stenosis (p = 0.012), female gender (p = 0.001) were significantly associated with PSD.Conclusions: The findings demonstrated that left middle cerebral artery and basilar artery stenosis are associated with PSD. It was suggested that cerebral artery stenosis was a risk factor of PSD and should be recognized and intervened early.Registration Number: ChiCTR-ROC-17013993.

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“…Participants were divided into three categories according to their alcohol intake status: non-drinkers, former drinkers, and drinkers. People who used to drink alcohol frequently in the past, but have not drunk in the past year before the ultrasound examination were de ned as former drinkers [29].…”

Section: Patients Enrollment and Study Designmentioning

confidence: 99%

Alcohol Quantity and Type on Risk of Gouty tophi

Han

Ren

et al. 2021

Preprint

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Objective: The aim of this study was to explore the impact of drinking alcohol on tophi and its surrounding inflammation in the joints by ultrasound. Methods: We conducted a cross-sectional study on 356 gout patients and collected their information of drinking history, clinical biochemical parameters and ultrasound results. Multiple regression analyses including several variables and potential confounders were then performed. Results: Relative to no drinking, more alcohol intake (>200 g/week), longer drinking time (>20 years) and higher frequency of drinking (>2 times/week) had significant positive effects on the size of tophus after controlling for potential confounders (P=0.024; P=0.002; P=0.040). Further subgroup analysis of different ages illustrated that more alcohol consumption had positive effects on the size of tophi only in the younger gout patients (≤50 years old), rather than in older ones (>50 years old). However, alcohol consumption had no significant association with the formation and number of tophus, and the associations between type of drinking and tophi was not observed in the current study. Moreover, except for tophi, there was no relationship between alcohol consumption and other ultrasound signs including double-contour sign (DCS), bone erosion, effusion and synovial hypertrophy.Conclusion: Alcohol consumption is closely associated with ultrasound-detected tophi in gout patients. More alcohol intake, longer drinking time and higher frequency of drinking are crucial factors that positively affect the size of tophus, especially in younger gout patients. However, significant association between type of alcohol and tophi was not observed in the current study.

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Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

Cited by 34 publications

References 55 publications

Imaging beta-amyloid (Aβ) burden in the brains of middle-aged individuals with alcohol-use disorders: a [11C]PIB PET study

Imaging beta-amyloid (Aβ) burden in the brains of middle-aged individuals with alcohol-use disorders: a [11C]PIB PET study

Association of Cerebral Artery Stenosis With Post-stroke Depression at Discharge and 3 Months After Ischemic Stroke Onset

Alcohol Quantity and Type on Risk of Gouty tophi

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