Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan

Hsu, Yun-Pung P.; Loh, E. W.; Chen, Wei-Jen; Chen, Chiao Chicy; Yu, Jianguo; Cheng, Andrew Tai Ann

doi:10.1176/ajp.153.9.1209

Cited by 53 publications

(5 citation statements)

References 5 publications

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“…Alcohol dependence is a multigenic disorder [ 5 ]. Several candidate genes have been studied, but results are controversial [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. In our last study alcoholics and nonalcoholics did not differ significantly in terms of 3-SNP GABRG1 haplotype frequencies.…”

Section: Introductionmentioning

confidence: 99%

Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology

Samochowiec

Chęć

Kopaczewska

et al. 2015

IJERPH

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Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch’s typology. Methods: DNA was provided from alcohol dependent (AD) patients (n = 370) and healthy control subjects (n = 168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods. Results: We found no association between alcohol dependence and MAOA gene polymorphism. Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

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Section: Introductionmentioning

confidence: 99%

Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology

Samochowiec

Chęć

Kopaczewska

et al. 2015

IJERPH

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“…Differences in MAOA activity levels were correlated with the number of active enzyme molecules15, which can result in the same effects as the regulation of expression. The effects of this low-activity allele of MAOA rs1137070 were similar to the low-expression variant of the upstream variable number tandem repeat region in the MAOA promoter, which was shown to increase the risk for alcohol addiction6, GM atrophy in cocaine abusers16, and antisocial-violent behavior in heroin abusers17.…”

Section: Discussionmentioning

confidence: 79%

“…The C allele of rs1137070 lacks a restriction endonuclease site and is associated with lower MAOA activity12. This genetic variation is associated with various psychiatric disorders5, including alcohol dependence6. Smoking behavior is also affected by rs1137070, suggesting a possible contribution of this variant to nicotine dependence7.…”

mentioning

confidence: 99%

“…The monoamine oxidase A ( MAOA ) gene is an X-linked gene that has been associated with various psychiatric disorders5, including addiction67, Monoamine oxidase A metabolizes and regulates biogenic amines, such as dopamine, norepinephrine, serotonin, and histamine at monoaminergic synapses in the brain8. The activity levels of MOAO vary widely among individuals9.…”

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confidence: 99%

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MAOA rs1137070 and heroin addiction interactively alter gray matter volume of the salience network

Sun

Liu

Feng

et al. 2017

Sci Rep

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The rs1137070 polymorphism of monoamine oxidase A (MAOA) is associated with alcoholism and smoking behavior. However, the association between rs1137070 and heroin addiction remains unclear. In this study, we examined the allelic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigated the interactive effects of rs1137070 and heroin addiction on gray matter volume (GMV) based on 78 heroin abusers and 79 healthy controls. The C allele frequency of rs1137070 was significantly higher in heroin abusers. Heroin addiction and the rs1137070 variant interactively altered measures of GMV in the anterior cingulate cortex, orbital frontal cortex, temporal pole, and insula, which were correlated with cognitive function. Heroin abusers with the C allele had lower measures of GMV in these regions than the healthy controls with the same allele, whereas those with the T allele displayed a different trend. The altered brain regions were connected with white matter tracts, yielding a structural network that partially overlapped with the salience network. These findings suggest that the low activity-related C allele of MAOA rs1137070 is associated with an increase in the sensitivity to heroin addiction and the damaging effects of heroin abuse on cognition and the salience network.

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“…They found significant associations between alcohol abuse and MAOA alleles in Han Chinese. However, this finding was specific for Han Chinese, but not among the aboriginal groups (207)(208)(209). Jin and associates (210) determined that the MAOA gene polymorphisms affect the origination of smoking in a Chinese cohort, persons with the 1460T/O and threerepeat VNTR genotypes had an appreciably higher risk for nicotine addiction.…”

Section: Dopamine Catabolism Genesmentioning

confidence: 98%

Neurogenetics of acute and chronic opiate opioid abstinence treating symptoms and the cause

et al. 2017

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This review begins with a comprehensive history of opioid dependence and treatment in the United States. The focus is an evidence-based treatment model for opioid/opiate dependent individuals. The role of reward genetic polymorphisms and the epigenetic modifications that lead to vulnerability to use and misuse of opiates/opioid to treat pain are reviewed. The neurochemical mechanisms of acute opiate withdrawal and opiate/opioid reward mechanisms are explored with a goal of identifying specific treatment targets. Alterations in functional brain connectivity based on neurobiological mechanisms in heroin dependence and abstinence are also reviewed. A new clinical model an alternative to merely blocking acute withdrawal symptoms as identified in the DSM -5 is proposed. Genetic diagnosis at the onset of detoxification, to determine risk stratification, and identify polymorphic gene targets for pharmaceutical and nutraceutical interventions, followed by the simultaneous initiation of Medication Assisted Therapy (MAT), to enable psychological extinction, and steady pro-dopaminergic therapy with the goal of developing "dopamine homeostasis" is recommended. The objective of these interventions is to prevent future relapse by treating all "Reward Deficiency Syndrome" (RDS) behaviors and eventually make an addiction-free life possible

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Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan

Abstract: Genetic heterogeneity may underlie alcoholism among different ethnic groups in Taiwan, and MAOA mutations may play a role in susceptibility to alcoholism among Han Chinese.

Cited by 53 publications

References 5 publications

Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology

Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology

MAOA rs1137070 and heroin addiction interactively alter gray matter volume of the salience network

Neurogenetics of acute and chronic opiate opioid abstinence treating symptoms and the cause

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