Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients

Fukuda, Sanae; Horiguchi, Mieko; Yamaguti, Kouzi; Nakatomi, Yasuhito; Kuratsune, Hirohiko; Ichinose, Hiroshi; Watanabe, Yasuyoshi

doi:10.1016/j.lfs.2012.11.016

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…The number of cases in these studies ranged from 35 to 171. Two articles did not specify the number of controls (Fukuda et al, 2013; Lee et al, 2009; Smith et al, 2006). All of the studies used 1994 Fukuda criteria as the definition of CFS (Fukuda et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

“…These mechanisms primarily included neurotransmitter dysregulation (five studies) (Fukuda et al, 2013; Narita et al, 2003; Smith et al, 2008, 2011; Sommerfeldt et al, 2011), hypothalamic-pituitary adrenal (HPA) axis regulation (two studies) (Lee et al, 2009; Rajeevan et al, 2007), inflammatory/immunomodulatory responses (four studies) (Carlo-Stella et al, 2006, 2009; Rajeevan et al, 2015; Smith et al, 2005), and other mechanisms involving metabolism and endurance (one study) (Vladutiu and Natelson, 2004)…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, polymorphisms in the monoamine synthetic enzymes, tyrosine hydroxylase ( TH ) (rs10770141), which synthesizes dopamine, and GTP cyclohydrolase I ( GCH ) (rs841), which is involved in the synthetic pathway of all the monoamines, have been associated with the pathophysiology of CFS (Fukuda et al, 2013). Two polymorphisms in the adrenergic signaling pathway, including the β2-adrenergic receptor and catechol-O-methyl transferase ( COMT ) that catabolizes noradrenaline, were found to be significantly more abundant in CFS patients than in controls; these were the GG genotype of rs1042714 and the AA genotype of rs4680, respectively (Sommerfeldt et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of the association between fatigue and genetic polymorphisms

Wang

Yin

Miller

et al. 2017

Brain, Behavior, and Immunity

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Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including single nucleotide polymorphisms (SNPs), especially in the regulatory regions, of relevant genes. To further investigate the association of SNPs with fatigue in various patient populations, a systematic search was conducted on Pubmed, CINAHL, PsycINFO, and Sociological Abstracts Database for fatigue related-terms in combination with polymorphisms or genetic variation-related terms. Fifty papers in total met the inclusion and exclusion criteria for this analysis. These 50 papers were further classified into three subgroups for evaluation: chronic fatigue syndrome (CFS), cancer-related fatigue (CRF) and other disease-related fatigue. SNPs in regulatory pathways of immune and neurotransmitter systems were found to play important roles in the etiologies of CFS, CRF and other disease-related fatigue. Evidence for associations between elevated fatigue and specific polymorphisms in TNFα, IL1b, IL4 and IL6 genes was revealed for all three subgroups of fatigue. We also found CFS shared a series of polymorphisms in HLA, IFN-γ, 5-HT and NR3C1 genes with other disease-related fatigue, however these SNPs (excluding IFN-γ) were not found to be adequately investigated in CRF. Gaps in knowledge related to fatigue etiology and recommendations for future research are further discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A systematic review of the association between fatigue and genetic polymorphisms

Wang

Yin

Miller

et al. 2017

Brain, Behavior, and Immunity

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“…The available research however, does evince a role for these polymorphisms in various psychological traits. Certain alleles of TH polymorphisms that result in higher promoter activity and increased DA synthesis such as the T-allele for the C(-824)T single nucleotide polymorphism (SNP) in the TH gene (Rao et al, 2007), have been associated with higher levels of persistence in psychiatric patients and higher levels of novelty seeking in healthy males (Fukuda et al, 2013;Sadahiro et al, 2010). These findings support the previously stated premise that higher DA activity can improve delay/effort tolerance during goal-directed behaviors (persistence) and attenuate the bias to select behavioral responses based on previous experiences (novelty-seeking).…”

Section: Da Turnover (Tyrosine Hydroxylase)mentioning

confidence: 99%

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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“…Rs1077014, located upstream of TH in the proximal promoter, affects the transcriptional activity of the promoter and the catecholamine secretion in humans [34]. Rs1077014 may be associated with persistence, a typical personality trait in chronic fatigue syndrome patients [35] as well as with the personality trait of novelty seeking in healthy men [36]. To our knowledge rs10840491 and rs10840489 have not been ascribed any functionality or association with schizophrenia or other mental disorders.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

Andreou

Söderman

Axelsson

et al. 2014

Behavioral and Brain Functions

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BackgroundHomovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are the major monoamine metabolites in the central nervous system (CNS). Their cerebrospinal fluid (CSF) concentrations, reflecting the monoamine turnover rates in CNS, are partially under genetic influence and have been associated with schizophrenia. We have hypothesized that CSF monoamine metabolite concentrations represent intermediate steps between single nucleotide polymorphisms (SNPs) in genes implicated in monoaminergic pathways and psychosis.MethodsWe have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder.ResultsThere were 42 nominally significant associations between SNPs and CSF monoamine metabolite concentrations, which exceeded the expected number (20) of nominal associations given the total number of tests performed. The strongest association (p = 0.0004) was found between MAOB rs5905512, a SNP previously reported to be associated with schizophrenia in men, and MHPG concentrations in men with psychotic disorder. Further analyses in 111 healthy individuals revealed that 41 of the 42 nominal associations were restricted to patients with psychosis and were absent in healthy controls.ConclusionsThe present study suggests that altered monoamine turnover rates in CNS reflect intermediate steps in the associations between SNPs and psychosis.

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Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients

Cited by 9 publications

References 25 publications

A systematic review of the association between fatigue and genetic polymorphisms

A systematic review of the association between fatigue and genetic polymorphisms

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

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