Association of mood disorders with cardiovascular disease risk factors in overweight and obese youth with elevated blood pressure

Medrano, Leah C; Amatya, Kaushalendra; Vizthum, Diane; Fadrowski, Jeffrey J.; Brady, Tammy M.

doi:10.1111/jch.13348

Cited by 7 publications

(6 citation statements)

References 50 publications

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“…We observed significantly increased plasma CRP concentrations in adolescents with obesity. Our result is similar to a study with 354 children with obesity and controls that showed strong correlations between CRP levels and adverse BP alterations, suggesting that oxidative stress can contribute to the development of CVD in children with obesity [42].…”

Section: Discussionsupporting

confidence: 91%

“…Overall, plasma leptin levels were higher in the OW, OB, and MO groups than in the NW group, similar to the literature [42]. Furthermore, an inverse correlation was observed between leptin plasma levels and HOMA, DBP, SBP, TRI, CRP, des-Arg 9 BK, and Ang I levels, as was an inverse correlation between ACE activity and Ang-(1-7) levels.…”

Section: Discussionsupporting

confidence: 88%

“…Uric acid is described as a marker of cardiovascular risk [42,43]. The MO group had a higher concentration of uric acid than the NW group and is another factor contributing to cardiovascular risk in subjects with obesity.…”

Section: Discussionmentioning

confidence: 99%

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Association of Ang-(1–7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents

Fernandes

Febba

et al. 2021

Hypertens Res

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Children with obesity have a high risk of developing cardiovascular disease and hypertension, which is associated with the renin-angiotensin system (RAS) activation and kallikrein-kinin system (KKS) inactivation. Although recent studies have identified several peptide-based biomarkers for obesity, circulating peptides from the RAS and KKS in adolescents with obesity have not been described. The aim of this study was to examine circulating levels of RAS and KKS peptides in adolescents with obesity to investigate the turnover of these peptides and their relationship to metabolic disorders resulting from weight gain. The subjects (n = 104) were divided into normal weight (NW), overweight (OW), obese (OB), and morbidly obese (MO) groups. Anthropometric profiles were created by measuring height, weight, blood pressure, and skinfolds. Plasma levels of Ang I, II, (1-7), BK, and des-Arg 9 BK were quantified by high-performance liquid chromatography. The levels were as follows:

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

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Association of Ang-(1–7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents

Fernandes

Febba

et al. 2021

Hypertens Res

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“…Objective studies have shown that adolescents with high BP demonstrated lower effectiveness in cognitive tests [35]. They also more often have emotional disorders, for example, mood disorders were observed in 37% of examinees [36]. In the case of pulmonary hypertension, the frequency of anxiety and depression exceeds 50% [37].…”

Section: Discussionmentioning

confidence: 99%

A Shift of the Parameters of the Cardiovascular System in Adolescents during the Period from 2004 to 2020 as a Result of Modification of Educational Environment

Nb¹,

Karganov²

2022

ujph

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The purpose of our study was to search for possible changes in the parameters of the cardiovascular system in adolescents during the period from 2004 to 2020 against the background of the introduction of digital technologies into the educational environment. Methods: A comparative analysis of the parameters of the cardiovascular system in female and male adolescents aged from 13.9 to 15.4 years was carried out (57 adolescents in 2004 and 53 adolescents in 2020). We used a spiroartheriocardiorythmograph allowing recording of heart rate (HR) and blood pressure (BP) and spectral parameters of HR variability and variability of systolic (sBP) and diastolic (dBP) BP. The parameters were recorded at rest in the sitting position for over two min. All studies were performed during school hours in February-March. Results: An increase in the mean sBP values and an increase in the proportion of adolescents with BP in the "hypertension" range to 55% were found in 2020. The total power of HR variability spectrum remained constant, while the relative power of the LF range increased and the absolute power of the VLF range tended to decrease. In the sBP variability spectrum, an increase in the total power and all its ranges was detected, but the relative power of the LF range decreased. In the dBP variability spectrum, the absolute power of the VLF range decreased, while the total power remained constant. No changes in the stress index and alpha index were detected.The dynamics of the parameters in male and female adolescents were similar. Conclusion: These findings indicate significant shifts in the parameters of the cardiovascular system in adolescents from 2004 to 2020 recorded during school hours analysis of the parameters of heart rate and BP variability reflecting the mechanisms of regulation of the cardiovascular system, suggests that the identified shifts were caused by psycho-emotional stress. We associate this state with the use of digital educational technologies. This trend requires the close attention of school health professionals. It would be expedient to establish the practice of BP measurements at school and share hygienic recommendations on working with digital technologies for students and their parents.

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“…Risk factors associated with MDS are varied. For example, some recent studies [ 4 – 6 ] reviewed and summarized risk factors for bipolar disorders, which included demographic (e.g., Black race, low education level) [ 7 , 8 ], genetic (e.g., familial genetic risk, multiple SNPs) [ 9 – 13 ] and environmental risk factors (e.g., childhood trauma and brain injury, medical comorbidities, and obesity) [ 5 , 12 , 14 – 16 ]. Specific to depression, the following risk factors are commonly identified: demographics, cognitive processes, stressful life events and circumstances, and behavior patterns [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Women and ethnoracial minorities with poor cardiovascular health measures associated with a higher risk of developing mood disorder

Guo

Stephens

Khan

et al. 2021

BMC Med Inform Decis Mak

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Background Mood disorders (MDS) are a type of mental health illness that effects millions of people in the United States. Early prediction of MDS can give providers greater opportunity to treat these disorders. We hypothesized that longitudinal cardiovascular health (CVH) measurements would be informative for MDS prediction. Methods To test this hypothesis, the American Heart Association’s Guideline Advantage (TGA) dataset was used, which contained longitudinal EHR from 70 outpatient clinics. The statistical analysis and machine learning models were employed to identify the associations of the MDS and the longitudinal CVH metrics and other confounding factors. Results Patients diagnosed with MDS consistently had a higher proportion of poor CVH compared to patients without MDS, with the largest difference between groups for Body mass index (BMI) and Smoking. Race and gender were associated with status of CVH metrics. Approximate 46% female patients with MDS had a poor hemoglobin A1C compared to 44% of those without MDS; 62% of those with MDS had poor BMI compared to 47% of those without MDS; 59% of those with MDS had poor blood pressure (BP) compared to 43% of those without MDS; and 43% of those with MDS were current smokers compared to 17% of those without MDS. Conclusions Women and ethnoracial minorities with poor cardiovascular health measures were associated with a higher risk of development of MDS, which indicated the high utility for using routine medical records data collected in care to improve detection and treatment for MDS among patients with poor CVH.

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Association of mood disorders with cardiovascular disease risk factors in overweight and obese youth with elevated blood pressure

Cited by 7 publications

References 50 publications

Association of Ang-(1–7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents

Association of Ang-(1–7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents

A Shift of the Parameters of the Cardiovascular System in Adolescents during the Period from 2004 to 2020 as a Result of Modification of Educational Environment

Women and ethnoracial minorities with poor cardiovascular health measures associated with a higher risk of developing mood disorder

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