Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort

Giacconi, Robertina; Kanoni, Stavroula; Mecocci, Patrizia; Malavolta, Marco; Richter, Dimitri; Pierpaoli, Sara; Costarelli, Laura; Cipriano, Catia; Muti, Elisa; Mangialasche, Francesca; Piacenza, Francesco; Tesei, Silvia; Galeazzi, Roberta; Theodoraki, Eirini; Lattanzio, Fabrizia; Dedoussis, George; Mocchegiani, Eugenio

doi:10.1016/j.jnutbio.2009.08.008

Cited by 23 publications

(17 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Quality of the analysis was assured by assessment of "quality standard samples" (SERONORM TM TRACE ELEMENT SERUM, Sero AS, Billingstad, Norway). Zn and Cu levels of the quality standard samples were within 10% of the certified levels, as previously reported [10]. Limits of detection estimated with the post-column calibration were 0.5 ppb for 65Cu, 5 ppb for 66Zn.…”

Section: Zinc and Copper Plasma Level Determinationssupporting

confidence: 85%

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation

et al. 2015

Self Cite

View full text Add to dashboard Cite

Zinc dyshomeostasis may lead to an augmented production of proinflammatory cytokines promoting chronic inflammation and increasing the susceptibility to age-related diseases. Several studies suggest that the zinc transporter protein ZIP2 may play a relevant role in the immune system especially during zinc deficiency, while a polymorphism on the coding region of ZIP2 gene (Gln/Arg/Leu) has been associated with severe carotid artery disease. The aim of this study is to investigate the role of ZIP2 SNP on zinc and inflammatory status in 1090 elderly healthy free-living subjects enrolled in the ZincAge project and to assess the effect of zinc supplementation on zinc status, inflammatory mediators, and zinc transporter expression depending on ZIP2 genotype. ZIP2 Leu- (Arg43Arg) carriers showed enhanced IL-6, TNF-α, and RANTES plasma levels associated with decreased free cytosolic zinc in PBMCs and an upregulation of zinc transporters ZIP2, ZIP8, and Znt1. Moreover, Leu- subjects displayed significant decrement of inflammatory mediators such as MCP-1, TNF-α, and RANTES following zinc supplementation. In summary, this investigation provides new evidence on the effect of ZIP2 Gln/Arg/Leu polymorphism on proinflammatory mediators and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype. These novel findings could be useful in identifying elderly subjects who may benefit of zinc intervention to decrease the inflammatory status and to prevent or delay the development of age-related diseases.

show abstract

Section: Zinc and Copper Plasma Level Determinationssupporting

confidence: 85%

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metallothioneins have been suggested in playing a cardioprotective role by regulating metal homeostasis and anti-oxidant response [44–46]. Recently, a human study found that individuals with the MT1A genetic polymorphism are predisposed to developing cardiovascular disease when there is an imbalance between oxidant production and antioxidant defenses [47]. In our study, MT1A was specifically identified in pygmy sperm whales liver.…”

Section: Discussionsupporting

confidence: 51%

Selenium protein identification and profiling by mass spectrometry: A tool to assess progression of cardiomyopathy in a whale model

Bryan

Bossart²,

Christopher

et al. 2017

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

Non-ischemic cardiomyopathy is a leading cause of congestive heart failure and sudden cardiac death in humans and in some cases the etiology of cardiomyopathy can include the downstream effects of an essential element deficiency. Of all mammal species, pygmy sperm whales (Kogia breviceps) present the greatest known prevalence of cardiomyopathy with more than half of examined individuals indicating the presence of cardiomyopathy from gross and histo-pathology. Several factors such as genetics, infectious agents, contaminants, biotoxins, and inappropriate dietary intake (vitamins, selenium, mercury, and pro-oxidants), may contribute to the development of idiopathic cardiomyopathy in K. breviceps. Due to the important role Se can play in antioxidant biochemistry and protein formation, Se protein presence and relative abundance were explored in cardiomyopathy related cases. Selenium proteins were separated and detected by multi-dimension liquid chromatography inductively coupled plasma mass spectrometry (LC-ICP-MS), Se protein identification was performed by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS), and Seprotein profiles were examined in liver (n = 30) and heart tissue (n = 5) by SEC/UV/ICP-MS detection. Data collected on selenium proteins was evaluated in the context of individual animal trace element concentration, life history, and histological information. Selenium containing protein peak profiles varied in presence and intensity between animals with no pathological findings of cardiomyopathy and animals exhibiting evidence of cardiomyopathy. In particular, one class of proteins, metallothioneins, was found to be associated with Se and was in greater abundance in animals with cardiomyopathy than those with no pathological findings. Profiling Se species with SEC/ICP-MS proved to be a useful tool to identify Se protein pattern differences between heart disease stages in K. breviceps and an approach similar to this may be applied to other species to study Se protein associations with cardiomyopathy.

show abstract

“…An association of the +647/+1245 MT1A haplotype in CVDs in a Greek cohort and a modulation of antioxidant enzyme activity suggests a possible reduced antioxidant function of some MT1 variants. Considering these last results, personalized antioxidant treatment could be useful to attenuate the disease progression in subjects with MT variants more susceptible to oxidative stress.…”

Section: Metallothionein and Diabetesmentioning

confidence: 96%

“…Few studies investigate the implication of MT polymorphisms with diabetes ant its cardiovascular and renal complications. +647 A/C and +1245 A/G MT1A SNPs have been related to diabetic complications in Italian and Chinese populations , while +647/+1245 MT1A haplotype have been associated with cardiovascular diseases in Greece . Interestingly, a recent investigation has demonstrated an independent association of MT2A A‐5G polymorphism, in the promoter region affecting MT2A production, with the risks of chronic kidney disease and DM2 in a large Japanese population .…”

Section: Zn Metabolism and Mt Function In Diabetic Nephropathy And Camentioning

confidence: 99%

Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy

et al. 2017

Self Cite

View full text Add to dashboard Cite

Impaired zinc homeostasis is observed in diabetes mellitus (DM2) and its complications. Zinc has a specific role in pancreatic β-cells via insulin synthesis, storage, and secretion. Intracellular zinc homeostasis is tightly controlled by zinc transporters (ZnT and Zip families) and metallothioneins (MT) which modulate the uptake, storage, and distribution of zinc. Several investigations in animal models demonstrate the protective role of MT in DM2 and its cardiovascular or renal complications, while a copious literature shows that a common polymorphism (R325W) in ZnT8, which affects the protein's zinc transport activity, is associated with increased DM2 risk. Emerging studies highlight a role of other zinc transporters in β-cell function, suggesting that targeting them could make a possible contribution in managing the hyperglycemia in diabetic patients. This article summarizes the current findings concerning the role of zinc homeostasis in DM2 pathogenesis and development of diabetic cardiomyopathy and nephropathy and suggests novel therapeutic targets. © 2017 BioFactors, 43(6):770-784, 2017.

show abstract

Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort

Cited by 23 publications

References 52 publications

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation

Selenium protein identification and profiling by mass spectrometry: A tool to assess progression of cardiomyopathy in a whale model

Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy

Contact Info

Product

Resources

About