2022
DOI: 10.5582/bst.2021.01306
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Association of MTHFR 677C>T polymorphism with pregnancy outcomes in IVF/ICSI-ET recipients with adequate synthetic folic acid supplementation

Abstract: Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphism rs1801133 (677C>T) will decrease the utilization of folate. Folate deficiency and its resulting homocysteine (HCY) accumulation can impair female fertility. Folic acid (FA) supplementation is necessary in pregnant women who are undergoing in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) -embryo transfer (ET), and especially in women with MTHFR rs1801133 C-to-T mutations. At present, affordable and accessible synthetic FA is ma… Show more

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Cited by 2 publications
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“…The MTHFR enzyme is a key enzyme in folate metabolism and is necessary for the homocysteine conversion to methionine (22). The 677 C>T MTHFR polymorphism results in decreased activity of MTHFR, causing an increase in homocysteine (Hcy) concentrations in body fluids (12). DNA damage and incorrect methylation caused by excess Hcy can impact the developing gametes and embryos (23).…”
Section: Discussionmentioning
confidence: 99%
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“…The MTHFR enzyme is a key enzyme in folate metabolism and is necessary for the homocysteine conversion to methionine (22). The 677 C>T MTHFR polymorphism results in decreased activity of MTHFR, causing an increase in homocysteine (Hcy) concentrations in body fluids (12). DNA damage and incorrect methylation caused by excess Hcy can impact the developing gametes and embryos (23).…”
Section: Discussionmentioning
confidence: 99%
“…There has been a long-standing interest in the relationship between MTHFR polymorphism(s) and pregnancy outcomes (16). Likewise, numerous studies have investigated the association between maternal MTHFR genetic polymorphism and adverse health outcomes (11,12,19). According to several reports, MTHFR polymorphisms in 677 C>T and hyperhomocysteinemia lead to decreased global sperm DNA methylation and are considered to be risk factors for semen parameters and human infertility (7,15).…”
Section: Discussionmentioning
confidence: 99%
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