Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects

Guo, Xingpo; Wang, Yihuan; Zhao, Hong; Song, Sanghyuk; Zhou, Jin; Han, Yongtao

doi:10.1007/s12094-013-1126-x

Cited by 18 publications

(11 citation statements)

References 40 publications

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“…ERCC1 is a critical protein in the nucleotide excision repair pathway that is responsible for repairing damaged DNA, functional genetic polymorphisms in the ERCC1 gene thus may alter DNA repair capacity and modulate cancer susceptibility [6]. The C8092A (rs3212986) and T19007C (rs11615) analyzed in the current study were the common SNPs in exons of ERCC2 gene.…”

Section: Discussionmentioning

confidence: 92%

“…Although increasing evidence suggests that environmental factors and chemical carcinogens, such as tobacco use and heavy alcohol intake, are probable etiological factors contributing to HNSCC susceptibility, only a small fraction of people exposed to these carcinogens will develop HNSCC [2,3]. HNSCC development is widely recognized as a stepwise process with involvement of a series of genetic alterations [4], and single-nucleotide polymorphisms (SNPs) for the associations between genomic regions and cancers in candidate genes offer a superior strategy for unraveling genetic complexity [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case–control studies

Ding

Gao

et al. 2015

Clin Transl Oncol

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The findings of the meta-analysis indicated that a decreased risk for the ERCC1 rs3212986 polymorphism was found among Asians, and an increased risk for the ERCC1 rs11615 polymorphism was found in overall HNSCC, especially in Asian subgroup and laryngeal site, suggesting that ERCC1 rs3212986 polymorphism in Asians may act as a protective factor and rs11615 polymorphism may be a risk factor for HNSCC.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case–control studies

Ding

Gao

et al. 2015

Clin Transl Oncol

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“…This transformation may increase the plasma homocysteine (Hcy) concentration and decreases the plasma folic acid concentration [ 26 ]. Recently, several meta-analyses indicated that MTHFR rs1801133 G>A polymorphism decreased the risk of CRC in Asians [ 27 , 28 ]. MTHFR rs1801133 G>A polymorphism locates on the NH2-terminal catalytic domain.…”

Section: Discussionmentioning

confidence: 99%

Investigation of methylenetetrahydrofolate reductase tagging polymorphisms with colorectal cancer in Chinese Han population

Zhang

Chen

et al. 2017

Oncotarget

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The aim of this case-control study was to assess the relationship between the tagging polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene and the susceptibility to colorectal cancer (CRC) in a Chinese Han population. A custom-by-design 48-Plex SNPscan Kit was used to determine the genotypes of MTHFR rs3753584 T>C, rs9651118 T>C, rs1801133 G>A, rs4846048 A>G and rs4845882 G>A polymorphisms in 387 CRC patients and 1,536 non-cancer controls. The results revealed that MTHFR rs1801133 G>A polymorphism was associated with a decreased risk of overall CRC. While MTHFR rs4845882 G>A polymorphism conferred an increased risk to overall CRC. In a stratified analysis by CRC region, we found MTHFR rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer. In addition, a significantly increased risk of rectum cancer associated with MTHFR rs3753584 T>C polymorphism was overt. However, MTHFR rs1801133 G>A polymorphism conferred a decreased risk to colon cancer. In conclusion, findings of the present study reveal that the tagging polymorphisms in MTHFR gene (rs3753584 T>C, rs9651118 T>C and rs4845882 G>A) are associated with the increased risk of CRC. However, MTHFR rs1801133 G>A polymorphism confers a decreased risk to CRC. Additional studies with larger sample size are needed to confirm these findings.

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“…The effects of MTHFR C677T polymorphism on cancer risk were controversial. Recent published meta-analyses showed that 677 C > T variation might contribute to the development of breast and esophageal cancer 47 48 ; however, a decreased cancer risk was observed in colorectal cancer 49 . Thus, MTHFR C677T polymorphism may play various roles in different carcinomas.…”

Section: Discussionmentioning

confidence: 99%

MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk

Zhuo

Song²,

et al. 2015

Sci Rep

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MTHFR C677T polymorphism has been indicated to be a risk factor for cancers, but its association with head and neck cancer (HNC) risk remains inconclusive. In the present study, we aimed to get a more precise estimation by performing a quantitative meta-analysis. Published papers up to Jun 2014 was searched and screened. Necessary information was rigorously extracted for data pooling and analyzing, and then, subgroup analyses on ethnicity, source of controls, sample size, tumor type, smoking and drinking status were also carried out. As a result, twenty-three case-control studies including 14298 subjects were included. The overall data failed to reveal a significant association between MTHFR C677T polymorphism and HNC risk (homozygote comparison model: OR = 1.16; 95%CI = 0.93-1.45; dominant model: OR = 1.05; 95%CI = 0.90-1.21; recessive model: OR = 1.14; 95%CI = 0.93-1.38). However, in the subgroup analysis about drinking status, increase risk was shown in the heavy drinking subgroup (TT vs CC: OR = 3.11; 95%CI = 1.52-3.02). In conclusion, the results of the present study suggest that Homozygous TT alleles of MTHFR C677T polymorphism might be a risk factor for HNC among individuals who have a heavy drinking history. Further studies are needed to get a more definitive conclusion.

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Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects

Abstract: This meta-analysis indicated that the MTHFR 677 TT homozygous genotype decreased the risk of CRC in Asians, while the MTHFR 677 CT heterozygous genotype did not contribute to CRC susceptibility.

Cited by 18 publications

References 40 publications

Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case–control studies

Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case–control studies

Investigation of methylenetetrahydrofolate reductase tagging polymorphisms with colorectal cancer in Chinese Han population

MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk

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