Association of multiple granular cell tumors and squamous carcinoma of the esophagus: case report and review of the literature

Abstract

This report describes the case of a man who underwent subtotal esophagectomy for the concomitant presence of a multifocal esophageal squamous carcinoma and a granular cell tumor (GCT); he had been previously affected by another metachronous esophageal GCT excised endoscopically. This is the sixth case described in the literature detailing other cases of a combination of malignancies involving additional organs. We emphasize the need for a prolonged surveillance of patients with multiple GCTs in order to promptly recognize the possibility of associated neoplasms.

Granular cell tumor of hypopharynx: report of a rare case

“…At present, the mechanism of the induction of PEH by GCTs is unclear. On the other hand, the coexistence of GCT and true squamous carcinoma in the same place has been reported [8,9].…”

Multifocal Granular Cell Tumor Presenting as an Esophageal Stricture

“…As more cases of multifocal GCTs are being reported in the past decade, many authors recommend complete endoscopic examination of upper and lower gastrointestinal tract in patients diagnosed with gastrointestinal GCTs [24,25]. This is further supported by recent studies showing increased yet unexplained association of granular cell tumor and other malignant cancers, namely squamous cell cancers [24,[26][27][28][29].…”

Esophageal Granular Cell Tumor Treated by Endoscopic Mucosal Resection. A Case Report and Review of the Literature

“…When the mucosal ulceration is present, esophageal carcinoma or another malignant tumor should be ruled out (4,5). The simultaneous presence of a GCT and an esophageal squamous carcinoma or other malignancies involving additional organs have also been reported (19).…”