Association of Mycoplasma genitalium with acute non-gonococcal urethritis

Horner, Patrick J; Gilroy, C B; Thomas, B J; Taylor‐Robinson, David; Naidoo, R.

doi:10.1016/0140-6736(93)91411-e

Cited by 192 publications

(124 citation statements)

References 13 publications

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“…Sexual transmission is suggested by demonstration of infection in urogenital sites of both men and women [5,6], and increased infection risk for female partners of infected men [7]. M. genitalium is associated with NGU, mucopurulent cervicitis, and other reproductive tract infections [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Mycoplasma genitalium among Adolescent Women and their Partners

Tosh

Pol

Fortenberry

et al. 2007

Journal of Adolescent Health

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Purpose-Mycoplasma genitalium is a possible sexually transmitted pathogen and its study among the adolescent age group has been limited. In this longitudinal study, the epidemiology, natural history, and associated clinical findings of M. genitalium among adolescents in a primary care setting were explored.Methods-A sample of 383 young women (14 -17 years of age) and 117 male partners provided sexual behavior data and urogenital samples for PCR testing to detect M. genitalium, Chlamydia trachomatis, and other sexually transmitted infections. Women were tested quarterly for up to 27 months and, during every other quarter, tested weekly. The presence of any signs or symptoms of infection among the female subjects was also documented.Results-Cumulatively, 13.6% (52/383) of women tested positive for M. genitalium. All women with M. genitalium, except one, were sexually experienced. M. genitalium was associated with number of sexual partners (p<0.001) and C. trachomatis infection (p<0.03). M. genitalium was more likely among male partners of M. genitalium-positive women (p<0.02). 31.3% of untreated M. genitalium cases had infection lasting ≥8 weeks. M. genitalium was not associated with the presence of clinical signs or symptoms of infection. Conclusions-Findings

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Section: Introductionmentioning

confidence: 99%

Mycoplasma genitalium among Adolescent Women and their Partners

Tosh

Pol

Fortenberry

et al. 2007

Journal of Adolescent Health

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“…El 15 a 25% de los casos agudos de UNG serían causados por M. genitalium y un porcentaje no bien determinado por Ureaplasma sp [5][6][7][8][9]21 .…”

Section: Discussionunclassified

“…Sin embargo, como ocurre con los otros micoplasma genitales, el microorganismo también ha sido detectado en personas sin signos o síntomas de infección genital 3,6 . El objetivo de este estudio fue determinar la frecuencia de M. genitalium en hombres con uretritis y en muestras vaginales de mujeres sexualmente activas.…”

Section: Universidad De Los Andes (Wgh)unclassified

“…Por este motivo su diagnóstico se basa en técnicas moleculares, como la hibridación con sondas y la amplificación del ADN mediante reacción de polimerasa en cadena (RPC) [3][4][5] . Varios estudios efectuados mediante RPC han detectado M. genitalium en 15 a 25% de hombres con UNG [5][6][7][8][9] . En la mujer, M. genitalium ha sido asociado con cervicitis 5,[10][11] , enfermedad inflama-muestras clínicas fueron obtenidas con tórula fina de algodón e inmediatamente inoculadas en medio de transporte Stuart y en 1,5 ml de buffer de transporte sacarosa fosfato (buffer 2SP).…”

Section: Materials Y Métodosunclassified

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Aplicación de método molecular en la detección de Mycoplasma genitalium en hombres y en mujeres embarazadas

et al. 2006

Rev. chil. infectol.

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“…In the 1990s, the advent of PCR-based assays facilitated studies on the association of M. genitalium with acute nongonococcal urethritis (NGU) (9, 11). This mycoplasma has been detected significantly more often in patients with acute NGU, particularly in patients with nonchlamydial NGU, than in subjects without urethritis (6,8). In 2002 we developed a TaqMan assay for quantification of M. genitalium DNA and quantified M. genitalium in first-pass urine of men with urethritis and of asymptomatic men (17).…”

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confidence: 99%

Longitudinal Quantitative Detection by Real-Time PCR of Mycoplasma genitalium in First-Pass Urine of Men with Recurrent Nongonococcal Urethritis

et al. 2002

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By using a TaqMan assay we monitored longitudinal changes in Mycoplasma genitalium loads in five men with recurrent M. genitalium-positive nongonococcal urethritis. We observed regrowth of M. genitalium persisting in hosts after treatment and a possible association of the increase in the M. genitalium load with emergence of symptoms and signs of nongonococcal urethritis in four of these patients.In 1981, when Mycoplasma genitalium was initially identified, two strains were isolated from two urethral specimens in culture (16). Despite repeated attempts to isolate M. genitalium from the urogenital tract, however, culture of M. genitalium is still immensely difficult. In the 1990s, the advent of PCR-based assays facilitated studies on the association of M. genitalium with acute nongonococcal urethritis (NGU) (9, 11). This mycoplasma has been detected significantly more often in patients with acute NGU, particularly in patients with nonchlamydial NGU, than in subjects without urethritis (6,8). In 2002 we developed a TaqMan assay for quantification of M. genitalium DNA and quantified M. genitalium in first-pass urine of men with urethritis and of asymptomatic men (17). We reported that the M. genitalium load was significantly higher in men with acute nonchlamydial NGU than in asymptomatic men (17). The various results reported to date suggest that M. genitalium may be associated with the development of acute NGU independent of Chlamydia trachomatis (2, 13).For chronic NGU, it has been suggested that persistence of M. genitalium in the urethra after antimicrobial chemotherapy might be associated with this condition (5,7,10,15). However, quantitative analysis of M. genitalium has been not performed in cases of chronic NGU. In the present study, therefore, we used the TaqMan assay to monitor longitudinal changes in M. genitalium loads in patients with recurrent NGU and to examine those cases for association of the M. genitalium load with clinical findings and inflammatory responses.Five men with recurrent NGU, who had been included in a previous study (10), were enrolled in the present study. They attended the Department of Urology, Toyota Memorial Hospital, Toyota, Japan, between July 1999 and December 2001. Each of these patients had symptoms and signs consistent with acute urethritis at the first visit. For each patient, Gramstained urethral smears showed five or more polymorphonuclear leucocytes (PMNLs) per high-power (ϫ1,000) microscopic field in at least three fields. Urine specimens were subjected to AMPLICOR STD-1 assay (Roche Diagnostics, Indianapolis, Ind.) for detecting Neisseria gonorrhoeae and C. trachomatis and to a PCR-and phylogeny-based assay for detecting mycoplasmas and ureaplasmas. The AMPLICOR STD-1 assay was done according to the manufacturer's instructions. The PCR-and phylogeny-based assay, which could detect at least 10 copies of the 16S rRNA gene of M. genitalium, was done as described in our previous report (18). Two patients were positive for both C. trachomatis and M. genitalium, and three w...

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Association of Mycoplasma genitalium with acute non-gonococcal urethritis

Cited by 192 publications

References 13 publications

Mycoplasma genitalium among Adolescent Women and their Partners

Mycoplasma genitalium among Adolescent Women and their Partners

Aplicación de método molecular en la detección de Mycoplasma genitalium en hombres y en mujeres embarazadas

Longitudinal Quantitative Detection by Real-Time PCR of Mycoplasma genitalium in First-Pass Urine of Men with Recurrent Nongonococcal Urethritis

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