Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease

Abstract

SummaryBackgroundThe aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters.MethodsLipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation.ResultsWe did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p=0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p<0.001), as well as the atherogenic index of plasma (p<0.001). Myeloperoxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p<0.05).ConclusionsChanges in AIP in children with ERSD are associated with the oxidative stress status and myeloper-oxidase concentration.

Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ

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Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

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“…Although it is suggested in the aforementioned study that neopterin is not specific in the evaluation of disease prognosis, there are many studies suggesting that neopterin is useful as a biological marker when following-up the clinical course of the disease or assess prognosis. Several studies have reported that serum or urine neopterin levels increase in cases of idiopathic or primary nephrotic syndrome, chronic and acute glomerulonephritis, and different stages of chronic kidney disease (7, 8, 9, 10), and it has been also shown that neopterin levels are elevated in patients with end-stage renal disease (ESRD) undergoing longterm hemodialysis, and that this increase is correlated with the duration of hemodialysis. Also in the aforementioned study it is demonstrated that in cases of human immunodeficiency virus (HIV) infection, the risk of developing acquired immune deficiency syndrome (AIDS) may increase in patients undergoing dialysis for more than one year.…”