Association of myocardial infarction with stressful life events and psychiatric symptoms: a population based survey

Hatmi, ZN; Lf, Nasiri; Sadegianmehr, Z; S, Mirkia; Darbooy, Shadan

doi:10.26719/2011.17.5.398

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Countries in Eastern Europe show a disproportionately high burden of IHD [ 17 ]. This high burden is difficult to attribute to any single factor, however, lifestyle, social stress, and alcoholism have been implicated [ 17 , 21 - 22 ]. In certain countries, the increased current burden could be attributed to changing population distributions [ 21 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study

Khan¹,

Hashim²,

Mustafa³

et al. 2020

Cureus

620

448

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Background Ischemic heart disease (IHD) is a leading cause of death worldwide. Also referred to as coronary artery disease (CAD) and atherosclerotic cardiovascular disease (ACD), it manifests clinically as myocardial infarction and ischemic cardiomyopathy. This study aims to evaluate the epidemiological trends of IHD globally. Methods The most up-to-date epidemiological data from the Global Burden of Disease (GBD) dataset were analyzed. GBD collates data from a large number of sources, including research studies, hospital registries, and government reports. This dataset includes annual figures from 1990 to 2017 for IHD in all countries and regions. We analyzed the incidence, prevalence, and disability-adjusted life years (DALY) for IHD. Forecasting for the next two decades was conducted using the Statistical Package for the Social Sciences (SPSS) Time Series Modeler (IBM Corp., Armonk, NY). Results Our study estimated that globally, IHD affects around 126 million individuals (1,655 per 100,000), which is approximately 1.72% of the world's population. Nine million deaths were caused by IHD globally. Men were more commonly affected than women, and incidence typically started in the fourth decade and increased with age. The global prevalence of IHD is rising. We estimated that the current prevalence rate of 1,655 per 100,000 population is expected to exceed 1,845 by the year 2030. Eastern European countries are sustaining the highest prevalence. Age-standardized rates, which remove the effect of population changes over time, have decreased in many regions.

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Section: Discussionmentioning

confidence: 99%

Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study

Khan¹,

Hashim²,

Mustafa³

et al. 2020

Cureus

620

448

View full text Add to dashboard Cite

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“…Social isolation has been identified as a risk factor for incident CVD [43]. Furthermore, SI [126] in CVD patients has been associated with increased recurrent cardiac morbidity and mortality, and accelerated development of carotid atherosclerosis is seen in isolated CVD patients [104].…”

Section: Part Iii: Isolation As a Factor In Cardiovascular Disease Anmentioning

confidence: 99%

One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition

2014

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The deleterious effects of chronic social isolation (SI) have been recognized for several decades. Isolation is a major source of psychosocial stress and is associated with an increased prevalence of vascular and neurological diseases. In addition, isolation exacerbates morbidity and mortality following acute injuries such as stroke or myocardial infarction. In contrast, affiliative social interactions can improve organismal function and health. The molecular mechanisms underlying these effects are unknown. Recently, results from large epidemiological trials and pre-clinical studies have revealed several potential mediators of the detrimental effects of isolation. At least three major biological systems have been implicated; the neuroendocrine (HPA) axis, the immune system, and the autonomic nervous system. This review summarizes studies examining the relationship between isolation and mortality and the pathophysiological mechanisms underlying SI. Cardiovascular, cerebrovascular, and neurological diseases including atherosclerosis, myocardial infarction, ischemic stroke and Alzheimer’s disease are given special emphasis in the context of SI. Sex differences are highlighted and studies are separated into clinical and basic science for clarity.

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“…[1–8] We recently found that self-reported stressful life events in the past year were independently associated with increased risk of future falls in older men. [9] Though we also found that stressful life events increased age-adjusted risk for incident clinical fracture nearly 60%, these results were attenuated and no longer statistically significant after additional adjustment for a one-time measurement of bone mineral density (BMD) and other factors.…”

Section: Introductionmentioning

confidence: 99%

Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study

Fink

Kuskowski²,

Cauley

et al. 2014

Osteoporos Int

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Purpose/Introduction Prior studies suggest that stressful life events may increase adverse health outcomes, including falls and possibly fractures. The current study builds on these findings and examines whether stressful life events are associated with increased bone loss. Methods 4388 men aged ≥65 years in the Osteoporotic Fractures in Men study completed total hip bone mineral density (BMD) measures at baseline and visit 2, approximately 4.6 years later, and self-reported stressful life events data mid-way between baseline and visit 2, and at visit 2. We used linear regression to model the association of stressful life events with concurrent annualized total hip BMD loss, and log binomial regression or Poisson regression to model risk of concurrent accelerated BMD loss (>1 SD more than mean annualized change). Results 75.3% of men reported ≥1 type of stressful life event, including 43.3% with ≥2 types of stressful life events. Mean annualized BMD loss was −0.36% (SD 0.88) and 13.9% of men were categorized with accelerated BMD loss (about 5.7% or more total loss). Rate of annualized BMD loss increased with the number of types of stressful life events after adjustment for age (p<0.001), but not after multivariable adjustment (p=0.07). Multivariable-adjusted risk of accelerated BMD loss increased with the number of types of stressful life events (RR, 1.10 [95% CI, 1.04–1.16]) per increase of 1 type of stressful life event). Fracture risk was not significantly different between stressful life event-accelerated bone loss subgroups (p=0.08). Conclusions In these older men, stressful life events were associated with a small, dose-related increase in risk of concurrent accelerated hip bone loss. Low frequency of fractures limited assessment of whether rapid bone loss mediates any association of stressful life events with incident fractures. Future studies are needed to confirm these findings and to investigate the mechanism that may underlie this association.

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Association of myocardial infarction with stressful life events and psychiatric symptoms: a population based survey

Cited by 5 publications

References 15 publications

Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study

Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study

One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition

Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study

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