Association of Myomectomy With Anti-Müllerian Hormone Levels and Ovarian Reserve

Aharon, Devora; Sekhon, L.; Getrajdman, Chloe; Naert, Mackenzie N.; Hanley, William; Kerr, Ahmad; Ghofranian, Atoosa; Hernández-Nieto, Carlos; Lee, Joseph A.; Copperman, A.B.; Ascher‐Walsh, Charles

doi:10.1097/aog.0000000000004983

Cited by 5 publications

(8 citation statements)

References 33 publications

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“…Similar to RT regarding the effect of uterine surgery on ovarian reserve, Aharon et al reported on AMH before and after myomectomy 14 . Their study found a significant decrease in AMH at 2 weeks postoperatively, although AMH recovered to baseline at 3 or 6 months.…”

Section: Discussionmentioning

confidence: 89%

“…Similar to RT regarding the effect of uterine surgery on ovarian reserve, Aharon et al reported on AMH before and after myomectomy. 14 Their study found a significant decrease in AMH at 2 weeks postoperatively, although AMH recovered to baseline at 3 or 6 months. This finding indicates that uterine surgical stress from RT and myomectomy may cause a temporary decrease in AMH levels in the early postoperative period.…”

Section: Discussionmentioning

confidence: 92%

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Effect of radical trachelectomy on ovarian reserve: A single‐institute prospective study

Nakagawa,

Tamauchi,

Sato

et al. 2023

J of Obstet and Gynaecol

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AimReduced responses to controlled ovarian stimulation (COS) after radical trachelectomy (RT) have been previously reported. We aimed to assess the effect of RT on ovarian reserve by measuring anti‐Müllerian hormone (AMH) levels before and after the procedure in this prospective study.MethodsWe included 12 patients who underwent RT between September 2019 and December 2021 in this study. Serum AMH levels were measured preoperatively, 1 month postoperatively, and 6 months postoperatively. Differences in the AMH levels were assessed using a paired t‐test.ResultsThe median age of the patients was 30.6 years, and the median follow‐up time was 30.1 months. AMH levels at 1 and 6 months postoperatively did not show a consistent trend. At 1 month postoperatively, the average AMH level decreased insignificantly but returned to preoperative levels at 6 months. The differences in AMH levels before and after RT were insignificant.ConclusionOur findings indicate that RT did not affect ovarian reserve as measured by AMH levels. However, the relationship between unchanged ovarian reserve and reduced response to COS remains unclear. Further research with larger sample sizes and additional measures of ovarian function is needed to corroborate these results and investigate the long‐term effects of RT on ovarian reserve. Understanding these mechanisms will help guide surgical practices and provide patients with valuable information about their reproductive outcomes after RT.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Effect of radical trachelectomy on ovarian reserve: A single‐institute prospective study

Nakagawa,

Tamauchi,

Sato

et al. 2023

J of Obstet and Gynaecol

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show abstract

“…Fan for their interest in our article in the December 2022 issue. 1 The authors suggest that patients with polycystic ovarian syndrome (PCOS) should be excluded from the study due to the association between PCOS and elevated anti-müllerian hormone (AMH) levels. Our study performed a paired analysis in which postoperative AMH levels were compared with the patient's baseline AMH level.…”

Section: In Replymentioning

confidence: 99%

“…In the December 2022 issue, Aharon et al 1 Patients with polycystic ovarian syndrome (PCOS), especially those with hyperandrogenism, obesity, or both, are more likely to have metabolic disorders 2 and to develop type 2 diabetes. 3 In these patients, AMH has been described as elevated.…”

Section: Association Of Myomectomy With Anti-mu ¨Llerian Hormone Leve...mentioning

confidence: 99%

“…In the December 2022 issue, Aharon et al 1 present a well-conducted study of 111 patients with scheduled open abdominal myomectomy or minimally invasive myomectomy. They investigated the relationship between the surgical method (open compared with minimally invasive myomectomy) and changes in postoperative ovarian reserve through detecting serum anti-müllerian hormone (AMH) levels.…”

mentioning

confidence: 99%

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