Association of Nasopharyngeal and Laryngopharyngeal Reflux with Postnasal Drip Symptomatology in Patients with and without Rhinosinusitis

Wise, Sarah K.; Wise, Justin C.; DelGaudio, John M.

doi:10.2500/ajr.2006.20.2849

Cited by 48 publications

(64 citation statements)

References 34 publications

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“…Our results were supported by another study that used SNOT-20 on reXux patients, which apparently only considered diVerences in postnasal drip (PND) between the patients and the controls [30].…”

Section: Discussionsupporting

confidence: 83%

Nose- and sinus-related quality of life and GERD

Katle

Hart²,

Kjærgaard

et al. 2011

Eur Arch Otorhinolaryngol

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Though some data indicate an association between gastroesophageal reflux disease (GERD) and upper airway inflammatory disease, a connection between GERD and chronic rhinosinusitis (CRS) is a matter of controversy in today's medicine. The aim of this study was to examine whether patients with GERD have a different nose- and sinus-related quality of life compared to a control group. A total of 77 patients with GERD diagnosed by gastroscopy were evaluated according to their nose- and sinus-related quality of life. It was scored using the Sino-Nasal Outcome Test-20 (SNOT-20). Total SNOT-20 score was compared with a control group consisting of 480 teachers. The average total SNOT-20 score in patients with GERD was 22.1, and in the control group 9.4 (p < 0.005). In the patient group, the median was 17.0 and standard deviation 18.4 corresponding to 5.0 and 11.5 in the controls. The 95% confidence interval in the patient group was (18.0, 26.3), and (8.3, 10.4) in the control group. Patients with GERD have a reduced nose- and sinus-related quality of life compared to a control group based on the fact that they have a significantly higher total SNOT-20 score than the controls. Accordingly, this study indicates that there is a causal relationship between GERD and CRS.

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Section: Discussionsupporting

confidence: 83%

Nose- and sinus-related quality of life and GERD

Katle

Hart²,

Kjærgaard

et al. 2011

Eur Arch Otorhinolaryngol

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“…47 One study found that patients with LPR had higher scores on the Sinonasal Outcome Test (SNOT-20), even in the absence of a diagnosis of CRS, 48 and another study showed that patients with LPR had higher scores for postnasal drainage. 49 Some of this association could be due to overlapping symptoms between LPR and CRS. However, a higher frequency of LPR determined by means of dual-channel 24-hour pH monitoring was found in a group of patients with CRS who had persistent CRS symptoms despite endoscopic sinus surgery 50 and a similarly higher frequency of LPR by pH monitoring and fluorometric pepsin assay of nasal secretions was found in a population of patients with CRS undergoing sinus surgery compared with a control group.…”

Section: Humoral or Innate Immune Deficiencymentioning

confidence: 99%

Chronic rhinosinusitis: Epidemiology and medical management

Hamilos

2011

Journal of Allergy and Clinical Immunology

361

296

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“…1 There exists a clear association between SERD and respiratory symptoms, including throat clearing, cough, asthma, postnasal drainage (PND), sinusitis, laryngopharyngitis, and sleep disturbance. [2][3][4][5] Many of these are frequent complaints among patients who seek consultation from an allergist. In one study, over half of patients presenting with throat clearing, PND, or excessive throat mucus and normal sinus imaging were found to have SERD by 24-hour pH monitoring.…”

Section: Introductionmentioning

confidence: 99%