Association of Neuroimaging Measures of Emotion Processing and Regulation Neural Circuitries With Symptoms of Bipolar Disorder in Offspring at Risk for Bipolar Disorder

Acuff, Heather E; Versace, Amelia; Bertocci, Michele; Ladouceur, Cecile D.; Hanford, Lindsay; Manelis, Anna; Monk, Kelly; Bonar, Lisa; Mccaffrey, Alicia; Goldstein, Benjamin I.; Goldstein, Tina R.; Sakolsky, Dara; Axelson, David; Birmaher, Boris; Phillips, Mary L.

doi:10.1001/jamapsychiatry.2018.2318

Cited by 42 publications

(6 citation statements)

References 78 publications

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“…Previous neuroimaging studies have reported deviation of brain structure among BD patients, including thinner cortex, increased volume, and surface of the right inferior frontal gyrus (Hanford et al, 2016, Roberts et al, 2017, Drobinin et al, 2019. One longitudinal neuroimaging study found greater anterior cingulate cortex activity and connection with amygdala while processing emotional regulation tasks in offspring of parents with BD; this study provides some evidence for the association of BD in families with de cits of neurodevelopment (Acuff et al, 2018).…”

Section: Offspring With Bdsupporting

confidence: 51%

Parental Mental Disorders and Ages of Onset of Severe Mental Disorders in Offspring: A Nationwide Family-link Study

Ching

Hsu

Tsai

et al. 2023

Preprint

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Objective Few studies have investigated the association between age of onset of severe mental disorders (SMDs) in offspring and the likelihood of diagnoses of parental mental disorder. Method We enrolled 212,333 patients with schizophrenia, bipolar disorder (BD), or major depressive disorder (MDD) and 2,123,329 controls matched for age, sex, and demographics from the National Health Insurance Database of Taiwan. Poisson regression models were used to examine the likelihood of diagnoses of five mental disorders in their parents compared to the parents of the controls (reported as odds ratio (OR) with 95% confidence interval), including schizophrenia, BD, MDD, alcohol use disorder (AUD), and substance use disorder (SUD). The study cohort was classified into child-onset, adolescent-onset, and adult-onset groups according to the onset of SMDs in the offspring. Result The parents of patients with child-, adolescent-, and adult-onset schizophrenia (OR range: 1.73–9.08, all p < 0.05) or BD (OR range: 1.97–8.17, all p < 0.05) were more likely to be diagnosed with schizophrenia, BD, MDD, AUD, and substance use disorder (SUD) than controls except for AUD in the child-onset group. However, the parents of patients with child-, adolescent-, and adult-onset depressive disorder were more likely to be diagnosed with schizophrenia, BD, MDD, AUD, and SUD (OR range: 1.82–4.76, all p < 0.05) than controls. Sub-analyses stratified by sex showed different patterns of associations between parental mental disorders and offspring mental disorders. Conclusion No matter when the SMD occurred during the developmental milestone, their parents had higher likelihood of being diagnosed with schizophrenia, BD, MDD, AUD, and SUD.

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Section: Offspring With Bdsupporting

confidence: 51%

Parental Mental Disorders and Ages of Onset of Severe Mental Disorders in Offspring: A Nationwide Family-link Study

Ching

Hsu

Tsai

et al. 2023

Preprint

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“…49 However, a preponderance of studies of individuals with BD have reported deficits in emotion regulation, excessive self-referential thinking, and rumination in depressed states, and reduced volumes and connectivities in prefrontal and limbic networks. These deficits have also been consistently implicated as risk factors for predicting the onset of BD in structural MRI, 12 task-based fMRI, [50][51][52] and resting state fMRI 53 studies of high-risk youths. It may be that the high-risk youth in our study were more depressed, treatment seeking, and at a different stage of illness than those in prior studies, showing increases in VLPFC-aDMN connectivity rather than the expected decreases in prefrontal and limbic connectivity that have been observed in youths with and at risk for BD.…”

Section: Discussionmentioning

confidence: 96%

Changes in Intrinsic Brain Connectivity in Family-Focused Therapy Versus Standard Psychoeducation Among Youths at High Risk for Bipolar Disorder

Singh

Nimarko

Garrett

et al. 2021

Journal of the American Academy of Child & Adolescent Psych

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“…Considering that limbic and associated brain structures, such as the amygdala, anterior cingulate cortex, hippocampi, prefrontal cortex, and basal ganglia (structures that play essential roles in cognitive processes like memory, attention, emotion, and perception) contain many enzymes and cytokines involved in an inflammatory response ( Raz & Rodrigue, 2006 ; Sudheimer et al, 2014 ; Rosenblat et al, 2015 ; Wang et al, 2015 ; Bortolato et al, 2015 ; Elias et al, 2017 ; Acuff et al, 2018 ); therefore, according to the available evidence, there is a probability of occurrence of these cognitive defects in these patients, which needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Probable Neuropsychological and Cognitive Complications Due to Cytokine Storm in Patients With COVID-19

Keshtgar

Chalabianloo

Esmaeili

2023

BCN

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Introduction: COVID-19 (coronavirus disease 2019) was identified in China in December 2019 for the first time and is rapidly spreading throughout the world as a pandemic. As COVID-19 causes mild to severe acute respiratory syndrome, most studies in this context have focused on pathogenesis primarily in the respiratory system. However, evidence shows that the central nervous system (CNS) may also be affected by COVID-19. Since COVID-19 is spreading, it is imperative to study its possible cognitive effects in patients suffering and recovering from COVID-19. Methods: The articles used in this study were searched by keywords such as Cytokine storm and covid-19, covid-19 and executive dysfunction, cognitive disorder and covid-19, CNS and covid 19, Coronavirus, Neuroinvasion in science direct, Scopus, PubMed, Embase, and Web of Science databases based on Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) checklist. The study will assess all observational studies published between December 2019 and April 2021 in peer-reviewed journals, including cross-sectional, cohort, case-control studies, case reports and case series. The search result was 106 articles, of which 73 articles related to Covid-19, the stages of infection by this virus, its effect on the nervous system and neurological symptoms, the cytokine storm caused by this infection, and the possible cognitive consequences caused by this virus in patients, has been reviewed. Other articles were not checked due to their limited relevance to the topic under discussion. Results: Studies show that neurons may be directly affected by SARS-CoV-1 and SARS-CoV-2. Furthermore, various studies indicate that systemic inflammation (so-called "cytokine storm") is also responsible for brain damage induced by infection with SARS-CoV-1 and SARS-CoV-2. Such a way that this patients showed elevated levels of interleukin (IL-), 6, 8, and 10 and of tumor necrosis factor-alpha (TNF- α) in their blood. Conclusion: Various cognitive defects following an increase level of cytokines such as TNF-α and IL-6,8 have been observed. Therefore, due to the increase level of these pro-inflammatory factors in the brains of these patients, cognitive deficits can be expected, which need further investigation.

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Association of Neuroimaging Measures of Emotion Processing and Regulation Neural Circuitries With Symptoms of Bipolar Disorder in Offspring at Risk for Bipolar Disorder

Abstract: Greater anterior cingulate cortex activity and functional connectivity during emotion regulation tasks may be specific markers of BD risk. These findings highlight potential neural targets to aid earlier identification of and guide new treatment developments for BD.

Cited by 42 publications

References 78 publications

Parental Mental Disorders and Ages of Onset of Severe Mental Disorders in Offspring: A Nationwide Family-link Study

Parental Mental Disorders and Ages of Onset of Severe Mental Disorders in Offspring: A Nationwide Family-link Study

Changes in Intrinsic Brain Connectivity in Family-Focused Therapy Versus Standard Psychoeducation Among Youths at High Risk for Bipolar Disorder

Probable Neuropsychological and Cognitive Complications Due to Cytokine Storm in Patients With COVID-19

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