Association of Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratio with Adverse Events in Endovascular Repair for Abdominal Aortic Aneurysm

Ntalouka, Maria P; Nana, Petroula; Kouvelos, George; Stamoulis, Konstantinos; Σπανός, Κωνσταντίνος; Giannoukas, Athanasios D.; Matsagkas, Miltiadis; Αrnaoutoglou, Eleni

doi:10.3390/jcm10051083

Cited by 19 publications

(17 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated NLR and PLR levels in peripheral artery disease have been linked to increased amputation rates, severe cardiovascular events, and death [ 32 , 33 ]. High values of these ratios were also associated with poor outcomes in the evolution of specific diseases, such as abdominal aortic aneurysm (AAA), chronic threatening limb ischemia (CTLI), and other cardiovascular emergencies [ 13 , 27 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. These biomarkers also proved to be predictive in oncology and oncological surgery, particularly in colorectal cancer, pancreatic cancer, gastric cancer, and cardiology and cardiac surgery [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 44 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Impact on Predicting Outcomes in Patients with Acute Limb Ischemia

Arbănași¹,

Mureșan

Coșarcă³

et al. 2022

Life

View full text Add to dashboard Cite

Acute Limb Ischemia (ALI) of the lower limb is defined as a sudden drop in arterial limb perfusion, which is a medical emergency requiring prompt intervention with high amputation and mortality rates in the absence of revascularization. This observational, analytical, and retrospective cohort study with longitudinal follow-up aimed to confirm the relevance of the preoperative inflammatory biomarkers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting the 30-day poor prognosis of patients with Rutherford classification (RC) grades II and III ALI. The ROC analysis found a strong association of an NLR > 4.33 with all studied outcomes, while a PLR > 143.34 was associated with all studied outcomes, except the composite endpoint in all RC stages. Depending on the optimal cut-off value, the ROC analysis found a higher incidence of all adverse outcomes in all high NLR (>4.33) and high PLR (>143.34) groups. A multivariate analysis showed that a high baseline value for NLR and PLR was an independent predictor of amputation (OR:11.09; 95% CI: 5.48–22.42; p < 0.0001; and OR:8.97; 95% CI: 4.44–18.16; p < 0.0001), mortality (OR:22.24; 95% CI: 9.61–51.47; p < 0.0001; and OR:8.32; 95% CI: 3.90–17.73; p < 0.0001), and composite endpoint (OR:21.93; 95% CI: 7.91–60.79; p < 0.0001; and OR:9.98; 95% CI: 3.89–25.55; p < 0.0001), respectively. Furthermore, for all hospitalized patients, the RC grade III (OR:7.33; 95% CI: 3.73–14.26; p < 0.0001) was an independent predictor of amputation (OR:7.33; 95% CI: 3.73–14.26; p < 0.0001), mortality (OR:8.40; 95% CI: 4.08–17.31; p < 0.0001), and composite endpoint (OR: 10.70; 95% CI: 4.48–25.56; p < 0.0001), respectively. The NLR and PLR are excellent predictors of risks associated with ALI for primary and secondary prevention. Our study showed that increased pre-operative values for NLR and PLR are indicators of a poor outcome in patients with RC grades II and III ALI.

show abstract

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Impact on Predicting Outcomes in Patients with Acute Limb Ischemia

Arbănași¹,

Mureșan

Coșarcă³

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…34,35 They have been identified as predictive factors of post-operative outcomes and mortality in patients with aortic diseases including dissections and aneurysms. [24][25][26][36][37][38][39][40] In addition, several studies have pointed to their interest as predictors of CI-AKI in patients undergoing cardiac procedures 41,42 or in patients undergoing diagnostic angiography for peripheral artery disease or carotid stenosis. 12,13 It has been hypothesized that pre-operative NLR and PLR could also serve as a predictive factor in patients undergoing AAA repair, 43 and our study corroborates that for the first time.…”

Section: Discussionmentioning

confidence: 99%

“…The neutrophil-to-lymphocyte ratio (NLR) was calculated by dividing the neutrophil count by the lymphocyte count; the platelet-to-lymphocyte ratio (PLR) was calculated by dividing the platelet count by the lymphocyte count, as previously described. [24][25][26] Plasma creatinine concentration was recorded preoperatively, at admission, within 7 days after surgery, between 7 and 30 days, and at the last follow-up when available. The eGFR was calculated according to the Chronic Kidney Disease Epidemiology collaboration (CKD-EPI) equation.…”

Section: Data Collectionmentioning

confidence: 99%

Incidence of Contrast-Induced Nephropathy and Post-Operative Outcomes in Patients Undergoing Chimney Endovascular Aortic Aneurysm Repair

Caradu¹,

Coatsaliou²,

Colacchio³

et al. 2022

Angiology

View full text Add to dashboard Cite

Chimney endovascular aortic aneurysm repair (ch-EVAR) has become a valid alternative to treat complex aneurysms but the occurrence of contrast-induced kidney injury (CI-AKI) is poorly known. This study investigated the incidence and the impact of CI-AKI on post-operative outcomes after ch-EVAR. Consecutive patients who underwent ch-EVAR between July 2010 and 2021 were retrospectively included. CI-AKI was defined based on plasma creatinine levels within 7 days after the intervention according to the “Kidney Disease Improving Global Outcomes” (KDIGO) classification. Among 102 patients included, CI-AKI occurred in 14 cases (13.7%). The 30-day post-operative mortality and complications were significantly higher in patients who developed CI-AKI compared with those who did not (50 vs 9.1%, P = .001 and 57.1 vs 20.5%, P = .007). Over a median follow-up of 24 months (3-39), overall mortality was also significantly higher (78.6 vs 33.0%, P = .002). The pre-operative platelet-to-lymphocyte ratio (PLR) was significantly higher in patients who developed CI-AKI (224.5 vs 147.6, P = .008). CI-AKI is frequent after ch-EVAR and is associated with worse post-operative outcomes. This should increase awareness of clinicians to optimize preventive and therapeutic strategies.

show abstract

“…Elevated NLR has been associated with an increased risk of atrial [65][66][67] and ventricular arrythmias [68] and with worse outcomes in acute decompensated heart failure [69] and acute coronary syndromes [70]. Besides CAD, NLR offers prognostic information in patients with abdominal aortic aneurysm [71], chronic threatening limb ischemia [72] and other cardiovascular emergencies [73][74][75][76][77]. NLR is also a biomarker of interest in severe mitral and aortic valvular heart disease [78,79] and is a predictor of poor FC in patients with HF (OR 3.085, 95% CI 1.52-6.26, p = 0.002) [80].…”

Section: Discussionmentioning

confidence: 99%

Value of the Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting CPET Performance in Patients with Stable CAD and Recent Elective PCI

et al. 2022

View full text Add to dashboard Cite

Background and Objectives: Functional capacity (FC) assessed via cardiopulmonary exercise testing (CPET) is a novel, independent prognostic marker for patients with coronary artery disease (CAD). Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are two readily available predictors of systemic inflammation and cardiovascular event risk, which could be used as cost-effective predictors of poor FC. The purpose of this study was to evaluate the utility of NLR and PLR in predicting poor FC in patients with CAD and recent elective percutaneous coronary intervention (PCI). Materials and Methods: Our cross-sectional retrospective analysis included 80 patients with stable CAD and recent elective PCI (mean age 55.51 ± 11.83 years, 71.3% male) who were referred to a cardiovascular rehabilitation center from January 2020 to June 2021. All patients underwent clinical examination, cardiopulmonary exercise testing on a cycle ergometer, transthoracic echocardiography and standard blood analysis. Results: Patients were classified according to percent predicted oxygen uptake (% VO2 max) in two groups—poor FC (≤70%, n = 35) and preserved FC (>70%, n = 45). There was no significant difference between groups regarding age, gender ratio, presence of associated comorbidities, left ventricular ejection fraction and NLR. PLR was higher in patients with poor FC (169.8 ± 59.3 vs. 137.4 ± 35.9, p = 0.003). A PLR cut-off point of 139 had 74% sensitivity and 60% specificity in predicting poor FC. After multivariate analysis, PLR remained a significant predictor of poor functional status. Conclusions: Although CPET is the gold standard test for assessing FC prior to cardiovascular rehabilitation, its availability remains limited. PLR, a cheap and simple test, could predict poor FC in patients with stable CAD and recent elective PCI and help prioritize referral for cardiovascular rehabilitation in high-risk patients.

show abstract

Association of Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratio with Adverse Events in Endovascular Repair for Abdominal Aortic Aneurysm

Cited by 19 publications

References 41 publications

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Impact on Predicting Outcomes in Patients with Acute Limb Ischemia

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Impact on Predicting Outcomes in Patients with Acute Limb Ischemia

Incidence of Contrast-Induced Nephropathy and Post-Operative Outcomes in Patients Undergoing Chimney Endovascular Aortic Aneurysm Repair

Value of the Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting CPET Performance in Patients with Stable CAD and Recent Elective PCI

Contact Info

Product

Resources

About