Association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with ER and PR in breast cancer patients and their changes after neoadjuvant chemotherapy

Xu, Jiali; Ni, Chao; Ma, Caihong; Zhang, L.; Jing, Xinxin; Li, Changxiao; Liu, Y.; Qu, Xun

doi:10.1007/s12094-017-1630-5

Cited by 40 publications

(33 citation statements)

References 25 publications

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“…Again, this study confirmed the association of a high NLR with worse survival, but importantly, also with recurrencefree survival after neoadjuvant chemotherapy [21]. Yet another study evaluating the response to neoadjuvant chemotherapy found that patients with low pretreatment NLR had better responses, although their cut-off for what was considered a 'low' NLR varied from the aforementioned report [22]. This highlights one of the issues associated with the classification of NLR, in that there is not a strictly defined cut-off value for its analysis.…”

Section: Nlrpredictive Of Metastasis?supporting

confidence: 68%

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

2017

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Evidence is mounting for a role for neutrophils in breast cancer progression to metastasis. However, the role of G‐CSF in neutrophil biology in a cancer setting remains to be defined. Herein we discuss the most recent clinical and experimental evidence for neutrophils and G‐CSF in the promotion of metastasis, demonstrating a potential mechanistic link between them. Understanding this link is imperative both for the development of diagnostic tests and for therapies targeting neutrophils to improve the treatment of breast cancer patients with or at risk of developing metastatic disease. As a high neutrophil‐to‐lymphocyte ratio in patients predicts poor outcome, while mild neutropenia predicts an improved outcome, we urge caution in the use of G‐CSF in neutrophil recovery following chemotherapy as there is increasing evidence in preclinical models that G‐CSF can promote metastasis.

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Section: Nlrpredictive Of Metastasis?supporting

confidence: 68%

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

2017

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“…Its prognostic value, however, should be regarded with caution and detailed clinical evaluation is needed before the ultimate prognostic significance of NLR in BC can be determined. Additional studies are required to prospectively evaluate the clinical value of pre-treatment NLR in BC, or its predictive significance for treatment response (31,32,39) and/or adverse events (40). Nevertheless, we believe that its determination might provide important information regarding risk stratification, especially in stage I patients in whom the presence of high NLR might raise the question as to whether they should be more aggressively managed.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Significance of Neutrophil–to–lymphocyte Ratio in the Framework of the 8th TNM Edition for Breast Cancer

et al. 2018

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“…53 In Xu et al research, their study showed that the patients with lower pretreatment NLR (<2.05) or PLR (<159.01) will have higher ERpositive expression, the patients with low NLR or low PLR would have a higher rate of complete remission (CR) and partial remission (PR) ( Figure 4A-D). 7…”

Section: Nlr and Plrmentioning

confidence: 99%

“…Recent epidemiological and clinical studies have found that inflammatory responses are associated with breast tumors. 6,7 Inflammation constitutes part of the tumor microenvironment, and changes in inflammatory cells affect tumor progression, including breast cancer cell proliferation, invasion, decreased immunity, metastasis, and so on. 8,9 Tumor inflammatory response may be a potential target for treating tumors.…”

Section: Introductionmentioning

confidence: 99%

<p>The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer</p>

Chen

Kong

Yan

et al. 2020

OTT

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Breast carcinoma is one of the most malignant tumors, severely influencing the physical and mental health of people. The latest epidemiological and clinical studies have found that breast tumor and inflammation are determinate relationships with each other. Inflammation is an essential component of the tumor microenvironment, and the change of inflammatory cells might influence tumor progression, such as neoplastic cell proliferation, migration, invasion, the collapse of antitumor immunity, metastasis and so forth. Peripheral blood tests at the time of diagnosis and treatment can reflect inflammatory conditions within the neoplasm. Evaluation of peripheral blood parameters including white blood cell, neutrophil, lymphocyte, monocyte, platelet counts, as well as neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (d-NLR) (neutrophil count divided by the result of white blood cell count minus neutrophil count), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), which are indicators of systematic inflammatory response, have been widely proposed as prognostic factors for many malignancies. To intensively study the relationship between the common markers in peripheral blood and the treatment or prognosis of breast cancer will have critical clinical significance and application prospect, and can provide useful information for the clinicians. Herein, we review the research progress in the prognostic role of the peripheral blood in breast cancer to provide a new method for the treatment and prognosis of breast cancer.

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Association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with ER and PR in breast cancer patients and their changes after neoadjuvant chemotherapy

Cited by 40 publications

References 25 publications

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

Prognostic Significance of Neutrophil–to–lymphocyte Ratio in the Framework of the 8th TNM Edition for Breast Cancer

<p>The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer</p>

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