Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients

Aygün, Fatih; Efe, Duran

doi:10.2147/ppa.s85577

Cited by 16 publications

(15 citation statements)

References 53 publications

(62 reference statements)

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“…Mean age of study participants ranged from 34.9 to 73.2 years. Some studies focused on patients with specific diseases including diabetic patients in 6 studies [ 14 , 16 , 23 , 30 , 43 , 44 ], gastric cancer in 1 study [ 40 ], CKD patients in 2 studies, and HIV patients in 1 study [ 47 ]. Percentages of patients having DM, HT, and DLP and smoking ranged within 0%-100%, 5.9%-80.9%, 12.4%-83.9%, and 0%-45.8%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

250

181

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Objective This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.

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Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

250

181

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“…Neutrophil–lymphocyte ratio, calculated by dividing the total neutrophil count by the total lymphocyte count ( 128 ), has been shown to be associated with coronary artery disease ( 7 , 129 , 130 ), atherosclerosis formation ( 131 ), adverse cardiac outcomes ( 132 – 134 ), and the metabolic syndrome ( 135 , 136 ) (Figure 5 ). The neutrophil–lymphocyte ratio is a cheap, commonly available ( 137 ), and stable marker which provides better predictive value than individual leukocyte counts ( 138 , 139 ).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, diabetic kidney disease accounts for the majority of cases of end-stage renal disease in developed countries ( 6 ) and is of increasing concern in developing countries ( 7 ). It is estimated that 40% of individuals with either type 1 or type 2 diabetes will go on to develop diabetic kidney disease ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that 40% of individuals with either type 1 or type 2 diabetes will go on to develop diabetic kidney disease ( 8 ). Rates of type 2 diabetes alone are estimated to double within the next 25 years to 352 million worldwide ( 7 ). Increasing numbers of patients with diabetes and subsequently diabetic kidney disease will place a significant financial burden on the healthcare system ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease

et al. 2018

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Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the rate of progression to end-stage renal disease. Diabetic kidney disease has been traditionally classified based on the presence of albuminuria. More recently estimated glomerular filtration rate has also been incorporated into the staging of diabetic kidney disease. While albuminuric diabetic kidney disease is well described, the phenotype of non-albuminuric diabetic kidney disease is now widely accepted. An association between markers of inflammation and diabetic kidney disease has previously been demonstrated. Effector molecules of the innate immune system including C-reactive protein, interleukin-6, and tumor necrosis factor-α are increased in patients with diabetic kidney disease. Furthermore, renal infiltration of neutrophils, macrophages, and lymphocytes are observed in renal biopsies of patients with diabetic kidney disease. Similarly high serum neutrophil and low serum lymphocyte counts have been shown to be associated with diabetic kidney disease. The neutrophil–lymphocyte ratio is considered a robust measure of systemic inflammation and is associated with the presence of inflammatory conditions including the metabolic syndrome and insulin resistance. Cross-sectional studies have demonstrated a link between high levels of the above inflammatory biomarkers and diabetic kidney disease. Further longitudinal studies will be required to determine if these readily available inflammatory biomarkers can accurately predict the presence and prognosis of diabetic kidney disease, above and beyond albuminuria, and estimated glomerular filtration rate.

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“…The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are inflammatory markers that can be easily, rapidly, and inexpensively determined. NLR and PLR have been used as markers of inflammation or metastasis in cancers 19 and inflammatory bowel disease, 20 as prognostic markers in ischemic heart disease, 21 and as screening tests for complications associated with DM. They have also been investigated as markers of the occurrence of hyperemesis gravidarum 22 and preeclampsia 23 and to determine the preeclampsia grade.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy?

Sargın¹,

Yassa²,

Taymur³

et al. 2016

TCRM

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ObjectiveWe aimed to investigate whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) could be utilized to screen for gestational diabetes mellitus (GDM).Subjects and methodsNLR and PLR were assessed by retrospective analysis of 762 healthy and pregnant women with GDM. The patients were stratified into four groups, as follows: GDM (n=144), impaired glucose tolerance (n=76), only screen positive (n=238), and control (n=304).ResultsThe leukocyte, neutrophil, and lymphocyte counts were significantly higher in the study groups compared with the control group (P=0.001; P<0.01). There were no statistically significant differences between the groups with respect to the NLR and PLR (P>0.05).ConclusionWe do not recommend that blood NLR and PLR can be used to screen for GDM. However, increase in the leukocyte count is an important marker for GDM as it provides evidence of subclinical inflammation.

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Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients

Cited by 16 publications

References 53 publications

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy?

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