Association of NKT cells and granulocytes with liver injury after reperfusion of the portal vein

Shimamura, Kazuhiko; Kawamura, Hiroki; Nagura, Toru; Kato, Takashi; Naito, Takaki; Kameyama, Hitoshi; Hatakeyama, Katsuyoshi; Abo, Toru

doi:10.1016/j.cellimm.2005.04.022

Cited by 53 publications

(64 citation statements)

References 35 publications

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“…NKT cells were found to be the major expander cell in the liver after IRI, and CD1d KO mice were protected from IRI [48]. The protective effect of A2AR activation in liver IRI was also associated with reduced activity of NKT cells [46].…”

Section: Different Roles Of T Cell Subsets In Irimentioning

confidence: 86%

Ischemia–reperfusion and immediate T cell responses

Huang¹,

Rabb²,

Womer³

2007

Cellular Immunology

135

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Section: Different Roles Of T Cell Subsets In Irimentioning

confidence: 86%

Ischemia–reperfusion and immediate T cell responses

Huang¹,

Rabb²,

Womer³

2007

Cellular Immunology

135

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“…We have previously shown that NKT cells are rapidly recruited to the liver after I/R (4). Other reports indicate that NKT cells contribute to liver injury induced by I/R (25,37). Therefore, we examined whether inhibition of NKT cell function by blocking its CD1d-dependent activation showed any effects on hepatic I/R injury.…”

Section: Activation Of Cd4 ϩ T Cells During Hepatic I/r Injury Is Parmentioning

confidence: 99%

“…Originally, it was thought that NKT cells could not play a role in postischemic tissue injury because of the absence of foreign antigen. However, recent published data have suggested that NKT cell activation by CD1d-dependent antigen presentation to TCR might be a key early event in the inflammation cascade during hepatic I/R injury (25,37). Furthermore, the generation of self-antigens has been described in models of gut and hindlimb I/R (43).…”

mentioning

confidence: 99%

Distinct contributions of CD4⁺T cell subsets in hepatic ischemia/reperfusion injury

Kuboki¹,

Sakai²,

Tschöp³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Recently, NKT cells have been shown to participate in hepatic IRI (7)(8)(9). Two types of NKT cells (type I and II) represent a subset of CD4 ϩ T cells, which possess features enabling their participation in the innate response since they can modulate Th cell differentiation and dendritic cell function (10).…”

Section: Nkt Cell Activation Mediatesmentioning

confidence: 99%

NKT Cell Activation Mediates Neutrophil IFN-γ Production and Renal Ischemia-Reperfusion Injury

Li¹,

Huang²,

Sung³

et al. 2007

The Journal of Immunology

300

355

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Previous work has shown that ischemia-reperfusion (IR) injury (IRI) is dependent on CD4+ T cells from naive mice acting within 24 h. We hypothesize that NKT cells are key participants in the early innate response in IRI. Kidneys from C57BL/6 mice were subjected to IRI (0.5, 1, 3, and 24 h of reperfusion). After 30 min of reperfusion, we observed a significant increase in CD4+ cells (145% of control) from single-cell kidney suspensions as measured by flow cytometry. A significant fraction of CD4+ T cells expressed the activation marker, CD69+, and adhesion molecule, LFA-1high. Three hours after reperfusion, kidney IFN-γ-producing cells were comprised largely of GR-1+CD11b+ neutrophils, but also contained CD1d-restricted NKT cells. Kidney IRI in mice administered Abs to block CD1d, or deplete NKT cells or in mice deficient of NKT cells (Jα18−/−), was markedly attenuated. These effects were associated with a significant decrease in renal infiltration and, in activation of NKT cells, and a decrease in IFN-γ-producing neutrophils. The results support the essential role of NKT cells and neutrophils in the innate immune response of renal IRI by mediating neutrophil infiltration and production of IFN-γ.

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Association of NKT cells and granulocytes with liver injury after reperfusion of the portal vein

Cited by 53 publications

References 35 publications

Ischemia–reperfusion and immediate T cell responses

Ischemia–reperfusion and immediate T cell responses

Distinct contributions of CD4⁺T cell subsets in hepatic ischemia/reperfusion injury

NKT Cell Activation Mediates Neutrophil IFN-γ Production and Renal Ischemia-Reperfusion Injury

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Association of NKT cells and granulocytes with liver injury after reperfusion of the portal vein

Cited by 53 publications

References 35 publications

Ischemia–reperfusion and immediate T cell responses

Ischemia–reperfusion and immediate T cell responses

Distinct contributions of CD4+T cell subsets in hepatic ischemia/reperfusion injury

NKT Cell Activation Mediates Neutrophil IFN-γ Production and Renal Ischemia-Reperfusion Injury

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Product

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Distinct contributions of CD4⁺T cell subsets in hepatic ischemia/reperfusion injury