Association of non-alcoholic fatty liver disease with microvascular complications of type 2 diabetes

Afarideh, Mohsen; Aryan, Zahra; Ghajar, Alireza; Ganji, Morsaleh; Ghaemi, Fatemeh; Saadat, Mohammad; Heidari, Behnam; Mechanick, Jeffrey I.; Esteghamati, Alireza

doi:10.1016/j.pcd.2019.03.009

Cited by 24 publications

(36 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study of Afarideh et al . 15 , patients with NAFLD had a lower average age and a shorter duration of type 2 diabetes mellitus compared with those without NAFLD. He also speculated that patients with NAFLD might participate in more regular and intense physical activity than non‐NAFLD patients to reduce the occurrence of microvascular complications.…”

Section: Discussionmentioning

confidence: 86%

“…The primary characteristics of nine articles 15 , 16 , 17 , 19 , 20 , 21 , 22 , 23 , 24 included are outlined in Table 1 . Overall, these nine articles from different countries involved 7,170 patients with type 2 diabetes mellitus (4,075 with NAFLD and 3,095 without NAFLD) and the sample size for each study was between 120 and 2,103.…”

Section: Resultsmentioning

confidence: 99%

“…Higher serum C‐peptide and insulin levels in the patients with NAFLD might reflect a relatively preserved β‐cell function, which could have beneficial effects on glycemic control, thus decreasing the occurrence of diabetic complications. In the study of Afarideh et al 15 ,. patients with NAFLD had a lower average age and a shorter duration of type 2 diabetes mellitus compared with those without NAFLD.…”

Section: Discussionmentioning

confidence: 95%

“…Thus, it is speculated that NAFLD may be a risk factor for diabetic retinopathy among patients with type 2 diabetes mellitus. Increasing research has shown that NAFLD and diabetic retinopathy may have common pathogenic mechanisms and interactions 15 , 16 , 17 . However, the evidence for a link between NAFLD and diabetic retinopathy is uncertain due to the small study populations and the borderline associations between NAFLD and traditional risk factors for diabetic retinopathy in the published literature.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association of non‐alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta‐analysis of observational studies

Song

Wang

et al. 2021

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction Non‐alcoholic fatty liver disease (NAFLD) is becoming more and more prevalent in type 2 diabetes mellitus. Evidence connecting NAFLD to diabetic retinopathy (DR) is increasing, but the results vary. Thus, we undertook a meta‐analysis to explore the effect of NAFLD on diabetic retinopathy in patients with type 2 diabetes mellitus. Materials and Methods PubMed, Embase, Cochrane and Scopus database were searched for until September 30, 2019. Original studies analyzing the association between NAFLD and diabetic retinopathy in the type 2 diabetic population were included. This meta‐analysis was processed by RevMan 5.3 software. Subgroup analyses based on countries were carried out. The pooled odds ratios and 95% confidence intervals were used to evaluate the association between NAFLD and diabetic retinopathy incidence. The I2 test was used to assess heterogeneity of studies. Results We retrieved 414 articles, and nine studies involving 7,170 patients were included in the final analysis. The pooled effects estimate suggested that NAFLD was not associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus. Subgroup analysis suggested that in China, Korea and Iran, patients with type 2 diabetes mellitus with NAFLD had a decreased risk for diabetic retinopathy compared with the non‐NAFLD individuals. However, in Italy and India, patients with type 2 diabetes mellitus with NAFLD had an increased risk for diabetic retinopathy compared with the non‐NAFLD individuals. In addition, no relevance between NAFLD and diabetic retinopathy was found in America. Conclusions On the whole, there was no association between NAFLD and diabetic retinopathy in individuals with type 2 diabetes mellitus. However, subgroup analysis showed that a difference of country may have an influence on the result.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of non‐alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta‐analysis of observational studies

Song

Wang

et al. 2021

J of Diabetes Invest

View full text Add to dashboard Cite

show abstract

“…Because of the potential increased risk of cardiovascular diseases among diabetic patients with concurrent NAFLD [23,24], there is a clinical need to identify the potential risk factors for NAFLD. Obesity has been reported to be significantly associated with NAFLD [25,26], and a meta-analysis of 21 cohort studies suggested that obesity independently resulted in 3.5-fold elevated risk of developing NAFLD compared with normal weight [26].…”

Section: Discussionmentioning

confidence: 99%

Association between hemoglobin levels and non-alcoholic fatty liver disease in patients with young-onset type 2 diabetes mellitus

et al. 2020

View full text Add to dashboard Cite

This retrospective study aimed to investigate the relationship between hemoglobin (Hb) levels and non-alcoholic fatty liver disease (NAFLD) in patients with young-onset type 2 diabetes mellitus (T2DM). Data were collected for 296 patients with young-onset T2DM admitted to the first Affiliated Hospital of Guangxi Medical University from May 2017 to January 2020. Subjects were divided into NAFLD (n = 186) and non-NAFLD groups (n = 110). Patients with NAFLD had significantly higher Hb levels (p = 0.001). According to logistic regression analysis, Hb levels were significantly correlated with NAFLD after adjusting for confounding factors [odds ratio (OR) = 1.024, 95% confidence interval = 1.003-1.046, p = 0.028]. Subjects were also grouped according to Hb quartiles. After adjusting for sex and body mass index (BMI), the OR (95%CI) for NAFLD significantly increased with increasing Hb levels (p for trend = 0.009). Patients were also divided into lean (BMI <25 kg/m 2 , n = 139) and overweight/obese groups (BMI ≥25 kg/m 2 , n = 157), with adjusted ORs (95%CI) for the highest quartiles of 1.797 (0.559-5.776) and 6.009 (1.328-27.181), respectively. Further quartile classification of Hb according to sex showed adjusted OR (95%CI) for the highest compared with the lowest quartile of 2.796 (1.148-6.814) for males and 2.945 (0.482-17.997) for females. In conclusion, high Hb levels were associated with the presence of NAFLD in patients with young-onset T2DM, especially in males and overweight/obese patients.

show abstract

Importance of non-invasive liver fibrosis scores for mortality and complications development in individuals with type 2 diabetes

Leite

Cardoso

Salles

2021

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

Association of non-alcoholic fatty liver disease with microvascular complications of type 2 diabetes

Cited by 24 publications

References 38 publications

Association of non‐alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta‐analysis of observational studies

Association of non‐alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta‐analysis of observational studies

Association between hemoglobin levels and non-alcoholic fatty liver disease in patients with young-onset type 2 diabetes mellitus

Importance of non-invasive liver fibrosis scores for mortality and complications development in individuals with type 2 diabetes

Contact Info

Product

Resources

About