Association of nonalcoholic fatty liver disease with changes in left ventricular structure and function: The coronary artery risk development in young adults (CARDIA) study

VanWagner, Lisa B.; Ning, Hongyan; Wilcox, Jane; Lewis, Clare; Lima, Jozely Francisca Mello; Carr, J. Jeffrey; Rinella, Mary E.; Shah, Silvi; Lloyd-jones, Don

doi:10.1016/s0168-8278(18)31922-6

Cited by 1 publication

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“…173 Cardiomyopathies NAFLD has been associated with morphological and structural changes in the myocardium. This was reported in the Coronary Artery Risk Development in Young Adults (CARDIA) study, 174,175 where NAFLD patients showed significant subclinical myocardial remodeling and dysfunction, possibly linking NAFLD to the onset of heart failure. Left atrium enlargement was also highly frequent in patients with an ultrasonographic diagnosis of NAFLD.…”

Section: Nafld and Atherosclerotic Cvdmentioning

confidence: 69%

Nonalcoholic fatty liver disease and cardiovascular disease phenotypes

et al. 2020

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Nonalcoholic fatty liver disease is increasingly recognized as a major global health problem. Intertwined with diabetes, metabolic syndrome, and obesity, nonalcoholic fatty liver disease embraces a spectrum of liver conditions spanning from steatosis to inflammation, fibrosis, and liver failure. Compared with the general population, the prevalence of cardiovascular disease is higher among nonalcoholic fatty liver disease patients, in whom comprehensive cardiovascular risk assessment is highly desirable. Preclinical effects of nonalcoholic fatty liver disease on the heart include both metabolic and structural changes eventually preceding overt myocardial dysfunction. Particularly, nonalcoholic fatty liver disease is associated with enhanced atherosclerosis, heart muscle disease, valvular heart disease, and arrhythmias, with endothelial dysfunction, inflammation, metabolic dysregulation, and oxidative stress playing in the background. In this topical review, we aimed to summarize current evidence on the epidemiology of nonalcoholic fatty liver disease, discuss the pathophysiological links between nonalcoholic fatty liver disease and cardiovascular disease, illustrate nonalcoholic fatty liver disease–related cardiovascular phenotypes, and finally provide a glimpse on the relationship between nonalcoholic fatty liver disease and cardiac steatosis, mitochondrial (dys)function, and cardiovascular autonomic dysfunction.

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Section: Nafld and Atherosclerotic Cvdmentioning

confidence: 69%