Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: Results from a multi-ethnic cohort

Veeranna, Vikas; Zalawadiya, Sandip; Niraj, Ashutosh; Kumar, Akhilesh; Ference, Brian А.; Afonso, Luís

doi:10.1016/j.ijcard.2011.11.034

Cited by 57 publications

(48 citation statements)

References 42 publications

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“…This study seems to suggest the superiority of RDW (an emerging cardiovascular biomarker) over hs-CRP (established cardiovascular risk marker) [20, 21] for cardiovascular risk prediction especially in general US population. Furthermore, another prior study of ours showed that the association of CRP with CVD is only in Caucasians [107] whereas RDW predicts CHD outcomes across ethnicities [106].…”

Section: J U S T a C C E P T E Dmentioning

confidence: 57%

Novel biomarkers with potential for cardiovascular risk reclassification

et al. 2016

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Precise estimation of the absolute risk for CVD events is necessary when making treatment recommendations for patients. A number of multivariate risk models have been developed for estimation of cardiovascular risk in asymptomatic individuals based upon assessment of multiple variables. Due to the inherent limitation of risk models, several novel risk markers including serum biomarkers have been studied in an attempt to improve the cardiovascular risk prediction above and beyond the established risk factors. In this review, we discuss the role of underappreciated biomarkers such as red cell distribution width (RDW), cystatin C (cysC), and homocysteine (Hcy) as well as imaging biomarkers in cardiovascular risk reclassification, and highlight their utility as additional source of information in patients with intermediate risk.

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Section: J U S T a C C E P T E Dmentioning

confidence: 57%

Novel biomarkers with potential for cardiovascular risk reclassification

et al. 2016

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“…Moreover, the association of D-dimer with pericardial fat volume was not significant in the alternative adjustment model with waist-to-hip ratio and height, suggesting a confounding effect of abdominal obesity. Two previous MESA studies have demonstrated no significant association of D-dimer and PAP with future cardiovascular events although elevated levels of these biomarkers are associated with a higher risk of total mortality [9,35]. In one of these studies, an ethnic difference was found in the circulating levels of CRP, fibrinogen, IL-6, factor VIII, D-dimer and PAP, suggesting that their association with CVD events may be influenced by ethnicity [9].…”

Section: Discussionmentioning

confidence: 99%

“…Plasmin-antiplasmin complex (PAP), a marker of active plasmin generation, was measured by a two-site ELISA [15]. Details on the measurement methods of these biomarkers have been described previously [9,10,16]. …”

Section: Methodsmentioning

confidence: 99%

“…A previous study using data from the Multi-Ethnic Study of Atherosclerosis (MESA) has shown that the associations of inflammation biomarkers with future cardiovascular events are modified by ethnicity. More specifically, the association is significant in Caucasians for CRP and in African Americans for IL-6 [9]. Given that ethnic difference in pericardial fat volume has also been reported [11], there may be an ethnic difference in the relationship of pericardial fat volume with biomarkers of systemic inflammation and hemostasis, and with future cardiovascular disease (CVD) events.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis

et al. 2015

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Objective Pericardial fat may increase the risk of cardiovascular disease (CVD) by increasing circulating levels of inflammation and hemostasis biomarkers. We investigated the associations of pericardial fat with inflammation and hemostasis biomarkers, as well as incident CVD events, and whether there are any ethnic differences in these associations. Methods We analyzed results from 6415 participants from the Multi-Ethnic Study of Atherosclerosis who had measurements of pericardial fat volume and circulating levels of C-reactive protein (CRP), fibrinogen, interleukin (IL)-6, factor VIII, D-dimer and plasmin-antiplasmin complex (PAP), and had a mean follow-up period of 9.5 years. Incident CVD event was defined as any adjudicated CVD event. Results After adjusting for confounding factors, pericardial fat volume was positively associated with natural log (ln) of IL-6 levels, but inversely associated with ln D-dimer and ln PAP levels (β=0.067, −0.032, and −0.105 respectively, all P<0.05). Although a larger pericardial fat volume was associated with a higher risk of incident CVD, the association was attenuated to borderline significance after adjusting for traditional cardiovascular risk factors (P=0.050). There was a borderline significant ethnicity interaction (P=0.080), whereby the association between pericardial fat volume and incident CVD was significant in Hispanic Americans, even after further adjusting for biomarkers of inflammation and hemostasis (hazard ratio=1.31 per SD increase, 95% confidence interval 1.09-1.57, P=0.004). Conclusion Pericardial fat was associated with several inflammation and hemostasis biomarkers. The association of pericardial fat with incident CVD events was independent of these biomarkers only among Hispanic Americans.

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“…However, these associations may differ by race, as African-Americans have higher levels of IL-6 [4][5][6][7][8] and CRP [5,8,9] but lower fracture risk [10][11][12]. Soluble CD14 (sCD14), a coreceptor for bacterial lipopolysaccharide, is a proinflammatory cytokine that may be more directly connected to bone health.…”

Section: Introductionmentioning

confidence: 99%

Soluble CD14 and fracture risk

et al. 2015

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Summary Soluble CD14 (sCD14) is an inflammatory marker associated with osteoclasts. Using Cox proportional hazards models, we found a positive association between plasma levels of sCD14 and risk of incident fracture among participants in the Cardiovascular Health Study. sCD14 may be useful in identifying those at risk for fracture. Introduction Soluble CD14, a proinflammatory cytokine, is primarily derived from macrophages/monocytes that can differentiate into osteoclasts. The purpose of this study was to examine the relationship between sCD14 levels and osteoporotic fractures. Methods In the Cardiovascular Health Study, 5462 men and women had sCD14 levels measured at baseline. Incident hip fractures (median follow-up time 12.5 years) and incident composite fractures (defined as the first hip, pelvis, humerus, or distal radius fracture, median follow-up 8.6 years) were identified from hospital discharge summaries and/or Medicare claims data. Cox proportional hazards models were used to model the association between sCD14 levels and time to incident hip or composite fracture, overall and as a function of race and gender.Results In unadjusted models, there was a positive association between sCD14 levels (per 1 standard deviation increase, i.e., 361.6 ng/mL) and incident hip (HR, 1.26; 95 % CI, 1.17, 1.36) and composite (HR, 1.20; 95 % CI, 1.12, 1.28) fractures. When models were fully adjusted for demographics, lifestyle factors, and medication use, these associations were no longer significant. However, in whites, the association of sCD14 levels with hip fractures remained significant in fully adjusted models (HR, 1.11; 95 % CI, 1.01-1.23). Associations of sCD14 levels with hip and composite fracture did not differ between men and women. Conclusions In this large cohort of community-dwelling older adults, higher sCD14 levels were associated with an increased risk of incident hip fractures in whites.

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Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: Results from a multi-ethnic cohort

Cited by 57 publications

References 42 publications

Novel biomarkers with potential for cardiovascular risk reclassification

Novel biomarkers with potential for cardiovascular risk reclassification

Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis

Soluble CD14 and fracture risk

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