Association of NPRA and NPRC gene variants and hypertension in Mongolian population

Abstract

ABSTRACT. NPRA and NPRC are candidate susceptibility genes for essential hypertension (EH) and play a key role in the regulation of plasma levels and biological effects of natriuretic peptides. The aims of the present study were to find new genetic markers in the NPRA and NPRC genes and to assess relationships between variants and EH. A total of 797 unrelated Mongolian herdsmen were enrolled, including 389 EH patients and 408 normotensive controls. Genotyping was performed using the polymerase chain reaction/ligase detection reaction assay. The distribution of the T-allele frequency of rs1847018 in NPRC differed significantly between hypertensive subjects and controls. There was an association between rs1847018 and EH in the additive model in NPRC (P < 0.05). There were no significant differences in the genotype and allele frequency distributions for any of the 3 single nucleotide polymorphisms in NPRA between EH and normotensive individuals. In NPRA, the frequency of haplotype TCA in the EH group was significantly lower than in controls, while the frequency of haplotype TCG was significantly higher in the EH group than in controls; Individuals who possessed the TCA haplotype had a significantly lower ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18494-18502 (2015) 18495NPRA and NPRC gene variants and hypertension ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18494-18502 (2015) risk of EH, whereas the presence of haplotype TCG was significantly associated with a higher risk of EH. However, there was no significant difference between the EH group and controls in any of the 8 haplo types in NPRC. Rs1847018 is a genetic marker of EH in NPRC, and the frequency of haplotype TCA and TCG in NPRA is associated with EH in the Mongolian population.

Meta-Analysis of Dilated Cardiomyopathy Using Cardiac RNA-Seq Transcriptomic Datasets

“…NPR3 (also known as NPR-C) encodes one of three receptors of natriuretic peptide which are small peptides responsible for regulating blood volume and pressure [29]. Several variations of NPR3 have been previously shown to be related to essential hypertension and coronary artery disease [30,31]. Follow-up functional studies are needed to investigate the mechanisms by which these genes contribute to the development of cardiomyopathy.…”