Association of NT-proBNP and interleukin-17 levels with heart failure in elderly patients

Abstract

ABSTRACT. Pro-B-type natriuretic peptide (NT-proBNP) and interleukin-17 (IL-17) are involved in the pathophysiological processes of heart failure; however, the exact role of IL-17 is not clear. We explored the relationship between IL-17 and NT-proBNP, as a clinical parameter, in heart failure. The whole blood IL-17 and NT-proBNP levels and the readmission rates in 70 patients with chronic heart failure class III or IV according to the New York Heart Association and 35 patients with normal heart function (control group) were measured and compared. The left ventricle ejection fractions (LVEFs) and NT-proBNP and IL-17 levels in cardiac functional class III (40.38 ± 4.76%, 7780 ± 6393 pg/mL, 8.65 ± 3.05 pg/mL, respectively) and class IV (31.59 ± 4.31%, 13,704 ± 10,945, 21.10 ± 10.60 pg/mL, respectively) were higher than those in the control group (61.27 ± 5.66%, 420 ± 256 pg/mL, 3.53 ± 2.05 pg/mL, respectively). Compared to the cardiac functional class IV, class III showed significantly higher values for LVEF and NT-proBNP and IL-17 levels (P < 0.05). The readmission rates of the patients in cardiac functional class III at 3 and 6 months (15.7 and 34.4%, respectively) and cardiac functional class IV at 3 and 6 months (39.5 and 76.3%, respectively) were significantly higher than those in the control group (0 and 5.7%, respectively) (P < 0.05). The NT-proBNP and IL-17 levels increased as the heart function worsened. NT-proBNP and IL-17 may play essential roles in the process of heart failure.

Galectin‐3 is associated with severe heart failure and death: A hospital‐based study in Chinese patients

“…IL‐17A is produced by activated T cells, has been shown to regulate myocardial fibrosis in experimental models of HF through a RANKL‐dependent mechanism . In our study, we observed an upregulated level of IL‐17A in patients and is in line with earlier findings showing a higher IL‐17A mRNA expression in congestive HF . In addition, we noticed lower level of TGF‐β in patients with HF as compared to healthy controls matched with earlier reports suggesting a decrease in circulating levels of TGF‐β1 during heart failure and it correlates with increased markers of inflammation …”

Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (<i>Macaca fascicularis</i>)

“…Similar to in humans, our data suggest that the levels of ANP and BNP may both be important leading indicators of cardiac disease in nonhuman primates. In humans, the level of NT-proBNP, a hormone that is produced by the decomposition of the BNP precursor proBNP, is also an important cardio-specific marker for heart failure [ 6 , 17 , 28 ]. However, NT-proBNP has specificities not only between animal species, but also between human races [ 16 ].…”

Role of Inflammation in Heart Failure

“…IL-17 induces myocardial fibrosis and decreases collagen synthesis. Elevated levels of IL-17 have been shown to be associated with advanced New York Heart Association (NYHA) classes of HF, III, and IV [19]. However, the role of IL-17 in HF progression is unclear.…”