Association of Obesity in Children with Pancreatitis in a Predominantly Hispanic Population at the US-Mexican Border: A Single Center Outpatient Study

Exocrine Pancreatic Insufficiency: A Case Report at the Mother and Child Center of the Chantal Biya Foundation

“…On the other hand, the hypercalcemia observed, unlike hypocalcemia expected with vitamin D deficiency can be explained by parathormone effect, although phosphatemia remained normal. However, the considerably lowered lipasemia, because secreted almost exclusively by the pancreas, permitted to attribute the disorders in our patient to EPI [1][2][3][4][5][6][7][8][9][10][11][12][30][31][32][33][34][35][36][37][38][39]. This contrasted with normal amylase level, but whose secretion is both salivary and pancreatic, and therefore less specific to EPI diagnosis.…”

“…Clinically, patients present with a malabsorption syndrome comprising steatorrhea with generally copious, oily, pale, and malodorous stools [1][2][3][4][5][6][7][8][9]. Thus, will follow a deficiency in fat-soluble vitamins (A, D, E, K), weight loss or lack of weight gain, growth retardation, bone damage and coagulation disorders [1][2][3][4][5][6][7][8][9][10][11][12][30][31][32][33][34][35][36][37][38][39]. On the paraclinical level, the biological malabsorption syndrome is manifested by a deficiency anemia in vitamin B-12 especially, a decrease in blood lipids, sometimes with the exception of triglycerides.…”

“…Nevertheless, frequent vomiting with metabolic alkalosis and loss of appetite caused both forms of anemia in our patient. It should be noted that despite the poor absorption of lipids reflected by their overall low blood level, serum lipoprotein lipase works to normalize triglyceridemia to the detriment of other lipids [1][2][3][4][5][6][7][8][9][10][11][12][30][31][32][33][34][35][36][37][38][39]. On the other hand, the hypercalcemia observed, unlike hypocalcemia expected with vitamin D deficiency can be explained by parathormone effect, although phosphatemia remained normal.…”

“…When faced with a maldigestion-malabsorption syndrome in pediatrics, cystic fibrosis is almost always evoked, due to its severity and epidemiological frequency, especially in Caucasians. Nevertheless, Lacrosniere, et al, in 2021 noted an increase in cystic fibrosis from 2 to 10% in blacks, 83% of which was expressed through exocrine pancreatic insufficiency [1][2][3][4][5][6][7][8][9][10][11][12][30][31][32][33][34][35][36][37][38][39]. However, the difficulties of access to molecular biology in our context made the exclusion of various genetic causes difficult at first sight.…”

“…We present a case of EPI, an exceptional pathology in pediatrics, which occurred in an infant born macrosome and who had a normal diet with breastfeeding before the onset of the disease [13][14][15][16][17][18][19][20]. This case allows us to highlight the diagnostic challenges due to metabolic repercussions and limited resource settings, as well as the therapeutic difficulties with a need for regular multidisciplinary follow-up [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Our discussion will be supported by a review of the literature on the topic.…”