Association of obesity susceptibility gene variants with metabolic syndrome in women

Abstract

Aim. The aim of the study was a replicative analysis of the association of polymorphic variants of genes associated with obesity revealed by results of wide-genomic studies (GWAS) with the development of a cluster of metabolic syndrome risk parameters in women of Bashkir and Tatar ethnicity. The polymorphic markers of the following genes were analyzed: SEC16B, FADS1, KCTD15, MAF, MAP2K5, NEGR1, BDNF, TMEM18.
 Materials and methods. The study involved 243 women with metabolic syndrome and 298 women without the metabolic syndrome. Amplification of DNA fragments was performed using real-time PCR and TaqMan technique.
 Results. We found the association the metabolic syndrome with genetic markers of genes MAF and TMEM18 from Tatar. Protective informative marker of the metabolic syndrome among Tatar and Bashkir was the TT haplotype TMEM18 gene (rs2860323 and rs6548238) (р=0.005 and р=0.001, respectively). We identified the association marker rs2241423 MAP2K5 gene with the level of waist circumference (p=0.003) and with the level of cholesterol (p=0.014), the marker rs11084753 KCTD15 gene with glucose levels after exercise (p=0.002), the level of triglycerides (p=0.003) and HDL (p=0.0008) among Tatar women. We identified the association rs2241423 MAP2K5 gene marker to glycated hemoglobin level (p=0.002) and a marker gene rs174550 FADS1 with triglyceride levels (p=0.02) among Bashkir women.
 Conclusion. It can be assumed that the polymorphic variants FADS1, KCTD15, MAF, MAP2K5, TMEM18 genes are an important part of the genetic structure of predisposition to metabolic syndrome and/or to a cluster of clinical and biochemical indicators of the risk of metabolic syndrome.

NOS1AP Gene Variants and Their Role in Metabolic Syndrome: A Study of Patients with Schizophrenia

“…Products of some genes play a role in the body’s energy metabolism, including, in particular, lipid metabolism: the apolipoprotein A5 gene ( ApoA5 ), the fat mass and obesity-associated gene ( FTO ), the fatty acid-binding protein 2 gene ( FABP2 ), the adipose triglyceride lipase gene ( ATGL ), the adiponectin gene ( ADIPOQ ), the adiponectin receptor gene ( ADIPOR2 ), and others [ 23 ]. Products of other genes are responsible for the formation of appetite and eating behavior ( TMEM18 , NEGR1 , and BDNF ) and are involved in inflammatory processes (potassium channel tetramerization domain-containing 15 [ KCTD15 ], MAF , and MAP2K5 ) [ 24 ]. At the same time, genes directly associated with mental disorders and genes responsible for metabolism regulation are considered potential markers of MetS in schizophrenia.…”