Association of obesity with cognitive function and brain structure in patients with major depressive disorder

Hidese, Shinsuke; Ota, Miho; Matsuo, Junko; Ishida, Ikki; Hiraishi, Moeko; Yoshida, Sumiko; Noda, Takamasa; Sato, Noriko; Teraishi, Toshiya; Hattori, Kotaro; Kunugi, Hiroshi

doi:10.1016/j.jad.2017.08.028

Cited by 48 publications

(53 citation statements)

References 48 publications

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“…BMI was negatively correlated with the BACS working memory, motor speed, and composite scores in the patient group. These correlations agree with prior findings [ 22 , 23 ], and with our recent study reporting that obesity is associated with poorer cognitive function in patients with major depressive disorder [ 35 ]. Increased BMI in schizophrenia may be associated with lower physical activity levels [ 20 , 23 ], although our data did not take physical activity into account.…”

Section: Discussionsupporting

confidence: 93%

Relationship of Handgrip Strength and Body Mass Index With Cognitive Function in Patients With Schizophrenia

et al. 2018

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Background: The relationship between muscle strength and cognition in schizophrenia has not been well studied. We investigated the potential relationship of handgrip strength (HGS) score and body mass index (BMI) with cognitive function in patients with schizophrenia.Methods: Participants included 153 patients with schizophrenia (age: 36.9 ± 9.4 years; 82 males) and 328 healthy controls (age: 36.4 ± 10.7 years; 150 males), matched for age, sex, and ethnicity (Japanese). HGS was measured using a digital handgrip dynamometer. Cognitive function was evaluated using the Brief Assessment of Cognition in Schizophrenia (BACS) test. A two-way multivariate analysis of covariance was used to compare HGS scores between the patient and control groups. Multiple regression analyses of BACS scores were performed in the patient and control groups using HGS and BMI scores as independent variables.Results: In the intergroup comparison, significantly lower HGS scores were observed in patients with schizophrenia than in healthy controls (p < 0.05, corrected). In the patient group, there was a significantly positive correlation between HGS scores and BACS composite score (male, p = 0.0014; female, p = 0.0051). However, BMI scores were significantly negatively correlated with the BACS composite score (male, p = 0.0022; female, p = 0.018). Furthermore, the ratio of HGS/BMI was significantly positively correlated with the BACS composite score in the patient group (p = 0.00000018).Conclusions: Cognitive function in patients with schizophrenia is correlated positively with HGS and negatively with BMI. HGS/BMI may thus be a good index for cognitive performance in schizophrenia.

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Section: Discussionsupporting

confidence: 93%

Relationship of Handgrip Strength and Body Mass Index With Cognitive Function in Patients With Schizophrenia

et al. 2018

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“…25,26 Other studies reported that obesity was associated with impaired cognitive function. [4][5][6][7] In a review, Loprinzi and Frith demonstrated that 10 out of 14 studies reported an inverse association between weight status and cognitive function. 7 In contrast, other studies found that a low BMI and decline in BMI were associated with an increased risk of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Association of body mass index and blood lipid profile with cognitive function in Chinese elderly population based on data from the China Health and Nutrition Survey, 2009–2015

Jiao

Wen

et al. 2020

Psychogeriatrics

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Aim: The associations of body mass index (BMI) and serum lipids with cognitive function are inconsistent and remain unclear, especially in the elderly population. This discrepancy triggered our interest in exploring the impact of BMI and serum lipids on memory status among the elderly Chinese population. Methods: Data were collected from the China Health and Nutrition Survey database. We used data from the survey's 2015 wave to examine the association between BMI and memory status and from the 2009-2015 surveys to examine the association between serum lipids and cognitive function. We performed multivariable logistic regression analyses and multivariable linear regression analyses to examine these associations. Results: Being underweight, normal weight, and severely obese were associated with an increased risk of bad self-reported memory status, with overweight as the reference. After adjustment for confounding factors, BMI was positively associated with cognitive function score in the low BMI group (≤24.5 kg/m 2) (β AE SE: 0.02 AE 0.01, P = 0.013) and negatively associated with cognitive function score in the high BMI group (>24.5 kg/m 2) (β AE SE: −0.04 AE 0.01, P = 0.009) in multivariable linear regression analysis. In men, higher levels of serum triglycerides and apolipoprotein B were associated with a decreased risk of cognitive impairment. In women, a higher level of high-density lipoprotein cholesterol was associated with a decreased risk of cognitive impairment. Conclusion: We found inverse U-shaped relationships between BMI and cognitive function and for the gender-specific association of serum lipids with cognitive function. This result indicated that among the elderly population, better nutritional status suggests superior memory status and cognitive function performance.

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“…42,43 Though the BACS-J is a test of neurocognition for schizophrenia, it has also been used for MDD. [44][45][46] It is composed of six subscales: verbal memory, working memory, motor speed, verbal fluency, attention and speed of information processing, and executive function. A higher score of the condition on hospitalization allows for the administration of more appropriate treatment on a priority basis.…”

Section: Cognitive Assessmentmentioning

confidence: 99%

Reduced Temporal Activation During a Verbal Fluency Task is Associated with Poor Motor Speed in Patients with Major Depressive Disorder

Kiriyama

Tanemura

Nakamura

et al. 2020

Psychiatry Investig

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Objective Substantial research has revealed cognitive function impairments in patients with major depressive disorder (MDD). However, the relationship between MDD cognitive function impairment and brain activity is yet to be elucidated. This study aimed to reveal this relationship using near-infrared spectroscopy (NIRS) to extensively measure frontotemporal cortex function.Methods We recruited 18 inpatients with MDD and 22 healthy controls. Regional oxygenated hemoglobin changes (oxy-Hb) were measured during a verbal fluency task and its relationship to cognitive function was assessed. Cognitive function was assessed using the Japanese version of the Brief Assessment of Cognition in Schizophrenia.Results Compared to healthy controls, patients with MDD displayed poorer motor speed, attention and speed of information processing, and executive function. In the bilateral prefrontal and temporal surface regions, regional oxy-Hb changes were significantly lower in patients with MDD than in healthy individuals. Moreover, we observed a correlation between reduced activation in the left temporal region and poor motor speed in patients with MDD.Conclusion We suggest that reduced activation in the left temporal region in patients with MDD could be a biomarker of poor motor speed. Additionally, NIRS may be useful as a noninvasive, clinical measurement tool for assessing motor speed in these patients.

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Association of obesity with cognitive function and brain structure in patients with major depressive disorder

Cited by 48 publications

References 48 publications

Relationship of Handgrip Strength and Body Mass Index With Cognitive Function in Patients With Schizophrenia

Relationship of Handgrip Strength and Body Mass Index With Cognitive Function in Patients With Schizophrenia

Association of body mass index and blood lipid profile with cognitive function in Chinese elderly population based on data from the China Health and Nutrition Survey, 2009–2015

Reduced Temporal Activation During a Verbal Fluency Task is Associated with Poor Motor Speed in Patients with Major Depressive Disorder

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