Association of obsessive‐compulsive disorder and pathological gambling with Huntington's disease in an Italian pedigree: possible association with Huntington's disease mutation

Marchi, Nicola; Morris, Meg E.; Mennella, R.; Pia, Silvestro La; Nestadt, Gerald

doi:10.1111/j.1600-0447.1998.tb09964.x

Cited by 33 publications

(22 citation statements)

References 18 publications

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“…The presence of obsessive and compulsive symptoms (OCs) has been previously documented in patients with HD as less common than other psychiatric symptoms [65,69,70,71,72]. However, a study by Marder et al reported that 22.3% had obsessive and compulsive symptoms at their first clinical visit, suggesting that these symptoms may be more common than previously recognized in this population.…”

Section: Clinical Features In Hd and Psychiatric Disordersmentioning

confidence: 93%

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Neuropsychiatric Burden in Huntington’s Disease

et al. 2017

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Huntington’s disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients’ autonomy and quality of life, also impacting patients’ social life. It is estimated that a prevalence between 33% and 76% of the main psychiatric syndromes may arise in different phases of the disease, often in atypical form, even 20 years before the onset of chorea and dementia. We present a narrative review of the literature describing the main psychopathological patterns that may be found in Huntington’s disease, searching for a related article in the main database sources (Medline, ISI Web of Knowledge, Scopus, and Medscape). Psychiatric conditions were classified into two main categories: affective and nonaffective disorders/symptoms; and anxiety and neuropsychiatric features such as apathy and irritability. Though the literature is extensive, it is not always convergent, probably due to the high heterogeneity of methods used. We summarize main papers for pathology and sample size, in order to present a synoptic vision of the argument. Since the association between Huntington’s disease and psychiatric symptoms was demonstrated, we argue that the prevalent and more invalidating psychiatric components should be recognized as early as possible during the disease course in order to best address psychopharmacological therapy, improve quality of life, and also reduce burden on caregivers.

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Section: Clinical Features In Hd and Psychiatric Disordersmentioning

confidence: 93%

“…They were found to be particularly important in an advanced stage of the disease. Those patients with an early age at onset of HD seem to be at an increased risk of psychoses [71]. A very low prevalence should be explained by a frequently use of neuroleptics [29].…”

Section: Clinical Features In Hd and Psychiatric Disordersmentioning

confidence: 99%

Neuropsychiatric Burden in Huntington’s Disease

et al. 2017

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“…De Marchi et al [69] reported on a family with HD, and a strong association between OCD and pathologic gambling. The lifetime prevalence of OCD in the extended family was 34% for biologically related persons, the majority of whom had HD or were at 50% risk.…”

Section: Comments and Outcome On Target Symptomsmentioning

confidence: 98%

An overview of psychiatric symptoms in Huntington’s disease

Anderson

Marder

2001

Curr Psychiatry Rep

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Huntington's disease (HD) is an inherited autosomal dominant disorder characterized by neurologic, cognitive, and psychiatric symptomatology. Psychiatric symptoms in HD are often amenable to treatment, and relief of these symptoms may provide significant improvement in quality of life. This review will briefly describe neurologic, neuropsychologic and brain imaging data, and then review psychiatric syndromes seen in HD and their treatment.

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“…It is noteworthy that patient 1 had suffered from OCD in the 25 years preceding the onset of her HD (De Marchi et al 1998), and that both cases came from an extended pedigree where an outstandingly high prevalence of OCD syndromes is being detected (manuscript in preparation). It can be argued that some clinical markers, such as the presence of OCD in this instance, might possibly help pinpoint distinct subgroups of HD patients, each with its specific neurotransmitting and neuroanatomical patterns of involvement (De Marchi and Mennella 2000).…”

Section: Discussionmentioning

confidence: 97%