Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness

Lamparter, Julia; Schmidtmann, Irene; Schuster, Alexander K.; Siouli, Angeliki; Wasielica‐Poslednik, Joanna; Mirshahi, Alireza; Höhn, René; Unterrainer, Josef M.; Wild, Philipp S.; Binder, Harald; Lackner, Karl J.; Beutel, Manfred E.; Münzel, Thomas; Pfeiffer, Norbert; Hoffmann, Esther M.

doi:10.1371/journal.pone.0197682

Cited by 50 publications

(45 citation statements)

References 24 publications

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“…The influence of lipid levels on retinal layer thickness has been previously investigated. A subgroup analysis of the Gutenberg Health Study (GHS) examining the influence of various factors on retinal nerve fiber layer (RNFL) thickness in a total of 1973 subjects showed no significant association between RNFL thickness and lipid levels in the multivariable model 34 . Similarly, the MIPH Eye&Health Study -investigating potential determinants of peripapillary RNFL thickness -found no association between the latter and lipid levels 35 .…”

Section: Discussionmentioning

confidence: 99%

Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

Jung

Bosch

Ott

et al. 2020

Sci Rep

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Spectral-domain optical coherence tomography (SD-oct) represents a reliable tool for retinal layer volume and thickness measurement. the aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (eSRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age-and gender-adjusted retinal layer volumes such as total retinal volume (p = 0.037), ganglion cell layer volume (GCL, p = 0.003), ganglion cell layer -inner plexiform layer volume (GCL-IPL, p = 0.005) and inner retinal layer volume (IRL, p = 0.042) of the right eye were lower in ESRD patients. Inner plexiform layer volume of both eyes (IPL, right eye: p = 0.017; left eye: 0.044) was reduced, as was RNFL thickness in the temporal superior sector (right eye: p = 0.016). A subgroup analysis excluding patients with diabetes revealed that GCL (p = 0.014) and GCL-IPL volume of the right eye (p = 0.024) and temporal superior sector of the RNFL scan (p = 0.021) in ESRD patients were still significantly thinner. We observed a decrease in several retinal layer volumes and temporal RNFL thickness indicative of retinal neurodegenerative processes in patients with eSRD.Within the last decade, optical coherence tomography (OCT) of the eye has evolved into a helpful and promising tool to non-invasively evaluate neuronal anatomy and vascular function in patients with various diseases 1-3 . Initially described by Huang et al. in 1991 4 , the first in-vivo application in a healthy volunteer followed in 1993 5 . Since then, various generations of OCT-devices have been developed. The evolution from time-domain to spectral-domain technology has led to an improvement of image quality, accuracy and velocity 6 .Nowadays, OCT has been established as a reliable high-resolution imaging technique that is frequently applied in clinical practice for the measurement of retinal layer thickness in patients with age-related macular degeneration 7-9 , glaucoma 10-13 , diabetic retinopathy 14,15 and other causes of optic neuropathy 16,17 . In addition, the OCT technology has become a valuable diagnostic tool in the assessment of neurodegenerative disorders, allowing the quantification of subtle changes in retinal nerve fiber layer (RNFL) thickness in patients with multiple sclerosis or Parkinson's disease [18][19][20][21][22] . A decrease in RNFL thickness or volume evaluated by OCT thereby represents an indicator of atrophy due to axonal and neuronal loss and multiple studies have shown that these alterations can be detected even earlier than through funduscopy 17,23 . Therefore, OCT allows a reliable estimation of axonal integrity of the anterior visual pathway 3,23,24 .In patients with ESRD, alterations like lenticular opacities, changes in choroidal and central corneal thickness, retinal layer thickness as well as intraocular pressure can be observed...

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Section: Discussionmentioning

confidence: 99%

Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

Jung

Bosch

Ott

et al. 2020

Sci Rep

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“…26 Additionally, another study reported a negative relationship between axial length and pRNFL thickness in a population-based cohort study. 27 It seemed that the elongation of the globe leads to mechanical stretching and thinning of the retina. In the present study, axial length did not show a significant result associated with pRNFL reduction in the control group.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Changes in the Peripapillary Retinal Nerve Fiber Layer Thickness in Hypertension: 4-Year Prospective Observational Study

Lee

Park

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine longitudinal changes in the peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with hypertension (HTN). METHODS. Participants without any ophthalmic disease were divided into two groups: an HTN group (50 eyes) that included patients with HTN for ‡5 years and a control group. After the initial visit, pRNFL thicknesses were measured four more times at 1-year intervals using spectral-domain optical coherence tomography. The pRNFL thickness was fitted using linear mixed models. Univariate and multivariate generalized linear mixed models were used to determine factors associated with pRNFL reductions over time. RESULTS. The mean ages of the HTN and control groups were 62.9 6 6.2 and 60.7 6 6.1 years, respectively, and they were not significantly different (P ¼ 0.089). The baseline mean pRNFL thicknesses were 90.50 6 8.31 and 93.90 6 8.77 lm; they were significantly different (P ¼ 0.049). The mean pRNFL reduction rate was À0.99 and À0.40 lm/y in the HTN and control groups, respectively; the interaction between group and duration was significant (P < 0.001). In the linear mixed model determination of factors associated with pRNFL reduction, there was no significant factor in the control group. In the HTN group, age, and axial length showed significant results in both univariate and multivariate analyses (estimate: À0.362 and À2.618; P ¼ 0.042 and 0.026, respectively). CONCLUSIONS. Patients with HTN had a significantly greater decrease in pRNFL than normal individuals. Additionally, age and axial length significantly affected the reduction in pRNFL in HTN patients.

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“…The following parameters were included in the multivariable model because they were considered to be associated with the pRNFL based on the medical literature [23][24][25] and were judged as being potentially associated with birth weight: (1) age, (2) sex, (3) axial length, (4) age-related macular degeneration, and (5) glaucoma (ISGEO definition).…”

Section: Covariatesmentioning

confidence: 99%

Association of Birth Weight with Peripapillary Retinal Nerve Fiber Layer Thickness in Adulthood—Results from a Population-Based Study

Fieß

Nickels

Urschitz

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Low birth weight is associated with altered retinal development in childhood, including reduced peripapillary retinal nerve fiber layer (pRNFL) thickness. However, to the best of our knowledge, no population-based study has analyzed the relationship of low birth weight to pRNFL thickness in adulthood. The purpose of this study was to investigate whether birth weight has a long-term effect on pRNFL thickness in adulthood. METHODS. In the German population-based Gutenberg Health Study (GHS), participants were examined with spectral-domain optical coherence tomography using a peripapillary scan and automated measurement of pRNFL thickness as a global parameter and in six sectors. The association between self-reported birth weight and the different pRNFL sectors were analyzed with multivariable linear regression, adjusted for potential confounders including sex, age, axial length, self-reported age-related macular degeneration, and glaucoma. RESULTS. In 3,028 participants, self-reported birth weight was documented and pRNFL measurements were successfully performed (1632 females, ages 54.9 ± 10.0 years). After adjustment for several confounders in the multivariable model, a positive association was observed between birth weight and pRNFL thickness in the global sector (β = 0.13 μm/100 g; 95% CI, 0.08-0.18; P < 0.001; R 2 = 0.007) and especially in the inferotemporal sector (β = 0.22 μm/100 g; 95% CI, 0.15-0.29; P < 0.001; R 2 = 0.008) and inferonasal sector (β = 0.28 μm/100 g; 95% CI, 0.17-0.39; P < 0.001; R 2 = 0.005). CONCLUSIONS. Our data show that there is a weak relationship between birth weight and pRNFL thickness in adulthood. This weak association is particularly present in the inferior part of the optic nerve head. Therefore, low birth weight may have an impact on optic nerve head development and potentially on ocular disease development.

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Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness

Cited by 50 publications

References 24 publications

Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

Longitudinal Changes in the Peripapillary Retinal Nerve Fiber Layer Thickness in Hypertension: 4-Year Prospective Observational Study

Association of Birth Weight with Peripapillary Retinal Nerve Fiber Layer Thickness in Adulthood—Results from a Population-Based Study

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