Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

Khoshi, Amirhosein; Bajestani, M Kaffash; Shakeri, Habibesadat; Goodarzi, Golnaz; Azizi, Fatemeh

doi:10.1186/s12944-019-1085-5

Cited by 38 publications

(38 citation statements)

References 42 publications

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“…At the genetic level, we genotyped rs12409609, a genetic variant located in the downstream regulatory region of omentin and that is in complete linkage disequilibrium with rs2274907, a missense polymorphism of the gene previously associated with CV risk [18][19][20] . In our study we did not observe any relationship between rs12409609 and axSpA nor with subclinical atherosclerosis in these patients.…”

Section: Discussionmentioning

confidence: 99%

Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Genre

Rueda-Gotor

Remuzgo‐Martínez

et al. 2020

Sci Rep

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Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. these data support a role of omentin as a CV risk biomarker in axSpA. Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the spine and pelvic joints. axSpA patients can also show a broad range of disease manifestations, including arthritis, enthesitis, dactylitis, psoriasis, uveitis and inflammatory bowel disease (IBD), among others. All this substantially affects the patient's quality of life and has important socioeconomic consequences 1. Besides, similarly to other chronic inflammatory rheumatic diseases, axSpA is also associated with a higher incidence of hypertension, obesity, dyslipidemia and smoking habit, which are considered classic risk factors for the development of cardiovascular (CV) disease. Moreover, the inflammatory status present in those patients further enhances their CV risk 2-4. In fact, CV disease is the main leading cause of mortality in patients with axSpA 4. 1 Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain.

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Section: Discussionmentioning

confidence: 99%

Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Genre

Rueda-Gotor

Remuzgo‐Martínez

et al. 2020

Sci Rep

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“…Bonder MJ had undergone the genome-wide analysis that for the association between common SNPs (minor allele frequency (MAF) > 0.05) and microbial taxonomy, and identi ed associations of 9 loci with microbial taxonomies and 33 Loci with microbial pathways [4]. Study in Iranian individuals reported the association of omentin rs2274907 gene polymorphisms with insulin resistance in with newly diagnosed type 2 diabetes [22]. But we didn't nd the difference of omentin rs2274907 gene polymorphisms between Uyghur T2DM and healthy normal group.…”

Section: Discussionmentioning

confidence: 99%

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Nuli

Shan

Zhang

et al. 2020

Preprint

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Background: Type 2 diabetes (T2DM) is a top risk factor for health in China. Gut microbiota, genetic factors and lipids metabolism play important role in development of T2DM. In this study, we investigated the relationship between the gut microbiota and omentin-1 gene polymorphism to explore the interaction between host gene and gut microbiota in Uyghur T2DM. Methods: A total of 98 newly diagnosed Uyghur T2DM patients and 99 healthy normal controls (NC) enrolled into this study according to inclusion criteria. The total DNAs was extracted from the fecal microbiota. Abundance of the Lactobacillus genus, Bacteroides thetaiotaomicron and Clostridium in the gut microbiota was determined with 16S rDNA gene Real-time fluorescence quantitative PCR amplification. PCR-PFLP was applied to determine the genotypes of Val109Asp variant (rs2274907) in the Omentin-1 gene. And the relationship between rs2274907 and gut microbiota was assessed. Results: There were no significant differences of the Val109Asp variant (rs2274907) between T2DM and NC group. The abundance of Lactobacillus genus and Clostridium genus was lower in newly diagnosed T2DM group than in the NC group (P<0.05). Serum insulin, LDL-C, the abundances of Lactobacillus genus and Clostridium genus were the risk factors of T2DM. (OR=1.094 95%CI 1.014-1.180), (OR=3.868 95%CI 1.250-11.971), (OR=0.288 95%CI 0.145-0.571), (OR=0.044 95%CI 0.012-0.154). Conclusions: The abundance of Lactobacillus and Clostridium genus may be related to the pathogenesis of new-onset T2DM in Uyghur population, the mechanism of which needs to be further studied. The interactive relationship between the gut microbiota and omentin-1 gene polymorphism in newly diagnosed T2DM was not observed in this study.

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“…The FTO gene encodes the protein that participates in energy metabolism, oxidative reactions and the metabolism of fatty acids. rs9939609 (Figure 33) is associated with an increase in the body mass index (BMI) and obesity [91,92]. The excessive expression of FTO is associated with a higher food intake and subsequent increases in body weight and fat, assuming that the level of energy expenditure and physical activity remain unchanged [93].…”

Section: Genes Responsible For Eating Preferencesmentioning

confidence: 99%

Genes and Eating Preferences, Their Roles in Personalized Nutrition

Vesnina

Prosekov

Kozlova

et al. 2020

Genes

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At present, personalized diets, which take into account consumer genetic characteristics, are growing popular. Nutrigenetics studies the effect of gene variations on metabolism and nutrigenomics, which branches off further and investigates how nutrients and food compounds affect genes. This work deals with the mutations affecting the assimilation of metabolites, contributing to nutrigenetic studies. We searched for the genes responsible for eating preferences which allow for the tailoring of personalized diets. Presently, genetic nutrition is growing in demand, as it contributes to the prevention and/or rehabilitation of non-communicable diseases, both monogenic and polygenic. In this work, we showed single-nucleotide polymorphisms in genes—missense mutations that change the functions of coded proteins, resulting in a particular eating preferences or a disease. We studied the genes influencing food preferences—particularly those responsible for fats and carbohydrates absorption, food intolerance, metabolism of vitamins, taste sensations, oxidation of xenobiotics, eating preferences and food addiction. As a result, 34 genes were identified that affect eating preferences. Significant shortcomings were found in the methods/programs for developing personalized diets that are used today, and the weaknesses were revealed in the development of nutrigenetics (inconsistency of data on SNP genes, ignoring population genetics data, difficult information to understand consumer, etc.). Taking into account all the shortcomings, an approximate model was proposed in the review for selecting an appropriate personalized diet. In the future, it is planned to develop the proposed model for the compilation of individual diets.

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Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

Cited by 38 publications

References 42 publications

Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Correlation study on gut microbiota and omentin-1 gene polymorphism in Uyghur newly diagnosed type 2 diabetes

Genes and Eating Preferences, Their Roles in Personalized Nutrition

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