Association of ovarian hyperthecosis with endometrial polyp, endometrial hyperplasia, and endometrioid adenocarcinoma in postmenopausal women: a clinicopathological study of 238 cases

Zhang, Cunxian; Sung, C. James; Quddus, M. Ruhul; Simon, Rebecca; Jazaerly, Tarek; Lawrence, W. Dwayne

doi:10.1016/j.humpath.2016.09.021

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…Reasonable effects have been observed with Tibolone, a synthetic steroid with estrogenic progestogenic and weak androgenic action that has the highest anti-oestrogenic activity. 106 Zhang et al 107 study was indicative that ovarian hyperthecosis with its resultant risk factor of hyperestrinism may be contributive to the pathogenesis of endometrial polyps in postmenopausal women.…”

Section: Conservative Non-surgical Treatmentmentioning

confidence: 99%

Endometrial polyps: Pathogenesis, sequelae and treatment

et al. 2019

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Endometrial polyps are overgrowths of endometrial glands that typically protrude into the uterine cavity. Endometrial polyps are benign in nature and affect both reproductive age and postmenopausal women. Although endometrial polyps are relatively common and may be accompanied by abnormally heavy bleeding at menstruation. In asymptomatic women, endometrial polyps may regress spontaneously, in symptomatic women endometrial polyps can be treated safely and efficiently with hysteroscopic excision.

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Section: Conservative Non-surgical Treatmentmentioning

confidence: 99%

Endometrial polyps: Pathogenesis, sequelae and treatment

et al. 2019

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“…The disorder shares its pathophysiology with PCOS in that both functional ovarian hyperandrogenism and insulin resistance contribute to the androgen excess state. However, unlike PCOS where theca cells are confined to the area around cystic follicles, nests of luteinised theca cells are scattered throughout the ovarian stroma in hyperthecosis, contributing to the high androgen levels usually seen 8 14. Ovarian hyperthecosis is seen primarily in postmenopausal women; its occurrence in women of reproductive age group is extremely rare 15.…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian hyperthecosis is a rare cause of severe hyperandrogenism. It manifests as LH-dependent functional ovarian hyperandrogenism and is characterised by the presence of nests of luteinised theca cells scattered throughout the ovarian stroma which secrete excess androgen 7–9. This disorder has been mainly described in postmenopausal women, and its occurrence in younger age group is extremely rare.…”

Section: Introductionmentioning

confidence: 99%

Severe hyperandrogenism due to ovarian hyperthecosis in a young woman

et al. 2019

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Hyperandrogenism is a relatively common clinical problem. However, severe hyperandrogenism causing virilisation is rare. A 27-year-old woman presented with generalised hirsutism, clitoromegaly, breast atrophy and secondary amenorrhoea. She had serum testosterone levels elevated to the adult male range. Administration of gonadotropin-releasing hormone (GnRH) analogue resulted in >50% suppression of serum testosterone which was suggestive of luteinising hormone-dependent ovarian hyperandrogenism. Imaging studies of abdomen and pelvis were normal, and ovarian venous sampling failed to show a gradient between the two sides. A presumptive diagnosis of ovarian hyperthecosis was, therefore, considered. Medical treatment with GnRH analogue and combined oral contraceptive pills was initiated to which an excellent clinical and biochemical response was noted. This case highlights a rare presentation of ovarian hyperthecosis in a young woman with severe hyperandrogenism mimicking a virilising neoplasm.

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“…Secondly, adjacent endometrium contained cancerous cells but was not collected for analysis. In the second hypothesis it is worth noting that the endometrium area adjacent to the polyp can be influenced by excessive estrogen stimulation, which is a known risk for the development of polyps, endometrial hyperplasia and endometrial cancer [21].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of histopathological examination results obtained during screening of patients with diagnosed atypical hyperplasia

Malinowski

Wilczyński

Depta

et al. 2018

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Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. The aim of this article is to increase knowledge of GSM. The current treatment options, both hormonal and non-hormonal, are reviewed. Topical estrogen therapy still remains the gold standard, but the demand for individually tailored therapy is growing. New treatment modalities are continuously included in clinical practice. They should consider the whole personality of a woman as well as cultural and social factors. Further studies on GSM and on the effectiveness of various treatment options are necessary to achieve this purpose.

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Association of ovarian hyperthecosis with endometrial polyp, endometrial hyperplasia, and endometrioid adenocarcinoma in postmenopausal women: a clinicopathological study of 238 cases

Cited by 21 publications

References 12 publications

Endometrial polyps: Pathogenesis, sequelae and treatment

Endometrial polyps: Pathogenesis, sequelae and treatment

Severe hyperandrogenism due to ovarian hyperthecosis in a young woman

Diagnostic value of histopathological examination results obtained during screening of patients with diagnosed atypical hyperplasia

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