Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

Abstract

To evaluate the oxidative stress and the C-reactive protein (CRP) in chronic obstructive pulmonary disease (COPD) patients and their correlation between the severity of the disease according to GOLD criteria and multidimensional indexes such as BODE index. A blood sample was collected for thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase, glutathione (GSH), homocysteine (HCY) and CRP analysis from 45 stable COPD patients. Lung function, body nutritional status, dyspnea and 6-min walk test (6MWT) were evaluated. Patients with GOLD stage IV presented a higher value for the TBARS than stage I patients (4.47 þ 1.58 versus 2.27 þ 1.04 nmol/mL, p < 0.05). CRP was higher for GOLD IV (2.46 þ 3.68 mg/dL) than other stages (GOLD I :

Incapacity, Handicap, and Oxidative Stress Markers of Male Smokers With and Without COPD

“…These results were partially consistent with those of Folchini et al, 35 who correlated BODE index and some oxidative stress biomarkers (glutathione, thiobarbituric acid-reactive substances, homocysteine, superoxide dismutase and catalase), and the only significant correlation was found between thiobarbituric acid-reactive substances and BODE index (r ϭ 0.51) of the COPD group. 35 How Can We Explain the Impairment of the COPD Smokers' QOL? Oxidative stress can be advanced as a hypothesis.…”

“…34 The present study calculated sample size (n ϭ 32; 16 COPD) is deemed to be satisfactory. However, it was smaller than those of Folchini et al 35 (cross-sectional study, n ϭ 45 COPD) and Lui et al 36 (case-control study, n ϭ 150; 100 COPD, 50 healthy smokers). The above studies aimed to evaluate the oxidative stress and the C-reactive protein in subjects with COPD and their correlation with COPD severity and BODE index 35 or the correlation between some serum inflammatory biomarkers and BODE index.…”

“…However, it was smaller than those of Folchini et al 35 (cross-sectional study, n ϭ 45 COPD) and Lui et al 36 (case-control study, n ϭ 150; 100 COPD, 50 healthy smokers). The above studies aimed to evaluate the oxidative stress and the C-reactive protein in subjects with COPD and their correlation with COPD severity and BODE index 35 or the correlation between some serum inflammatory biomarkers and BODE index. 36 The SGRQ was applied because it is the only questionnaire that has a validated French version 37 and is the most widely used instrument for assessing health-related QOL (HRQOL).…”

“…9 The Voorrips physical activity questionnaire 10 was applied because it is frequently used to measure habitual physical activity, and it is a validated questionnaire for young as well as elderly people in apparently good health. 17,28 It is important to highlight that the studies of Liu et al 36 and Folchini et al 35 have not evaluated their subjects' QOL and physical activity status. The choice of the 6MWT to evaluate submaximal exercise capacity and precautions taken during the walk are discussed in the supplementary data.…”

Airway inflammation and tiotropium treatment in stable COPD patients

“…As a result of inhaled toxic gases, mainly tobacco smoke, increased oxidative stress with reactive oxygen species (ROS) and increased inflammation with neutrophils, macrophages, and CD8+ T lymphocytes form a vicious cycle that is implicated in the remodeling of the airways and lung parenchyma (2,3). Examination of exhaled breath condensate (EBC) is a noninvasive method for studying the composition of airway lining fluid.…”