Association of Oxidative Stress with Polycystic Ovarian Syndrome in Oman: A Case‐Control Study

Abstract

BackgroundPrevious studies in Euro‐American populations have shown that women with polycystic ovarian syndrome (PCOS) have increased levels of serum oxidative stress markers. In the Arab region, there is noticeable lack of research of the association between oxidative stress and PCOS.ObjectiveThis study aims to compare socio‐demographic, clinical characteristics and oxidative stress indices between women diagnosed with PCOS and non‐PCOS women.MethodsThis hospital based case‐control study was conducted among women aged 16–49 years. The study included 51 women diagnosed with PCOS (as per Rotterdam 2003 criteria) and 45 control women who were known not to have PCOS. Serum blood samples were collected to measure biomarkers of oxidative stress including glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), and total antioxidant capacity (TAC) using commercially available kits.ResultsReduced GSH levels (P= 0.006) were significantly lower among PCOS women compared to non PCOS women. GR and GPx activity levels showed higher trends in women with PCOS compared to non PCOS women and the difference was significant for the GPx activity (P= 0.04). PCOS women also showed lower TAC levels (P= 0.08) than the control group with no significant difference between the two groups.ConclusionThe study provides a supportive evidence for the association between oxidative stress and PCOS among Omani women. Oxidative stress might play a role in pathogenesis of PCOS, so these parameters may be suggested as diagnostic markers for early diagnosis and screening of high risk groups.Support or Funding InformationSultan Qaboos UniversityThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

“…A case-control study of 51 women with PCOS and 45 control women determined that the women with PCOS had significantly lowered levels of glutathione (GSH) and TAC, which indicates the role of oxidative stress in the pathogenesis of PCOS [54]. In addition, elevated levels of MDA and lowered levels of SOD and TAC have been observed among women with PCOS in a nested case-control study of 50 women with PCOS and 50 control women [55].…”