Association of p21 3′ UTR gene polymorphism with cancer risk: Evidence from a meta-analysis

Abstract

Numerous studies have investigated the risk of cancer associated with the polymorphism of p21 3′ UTR (rs1059234 C > T), but results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of the association between this polymorphism and risk of cancer. A comprehensive search was conducted to identify all case-control studies of the rs1059234 C > T polymorphism of p21 3′ UTR and cancer susceptibility. A total of eleven eligible studies, including 3,099 cases and 4,354 controls, relating to the rs1059234 polymorphism of p21 3′ UTR to the risk of cancer were identified. Multivariate and univariate methods revealed no association between this polymorphism and cancer risk. However, subgroup analysis by cancer type suggested that rs1059234 C > T polymorphism was associated with increased risk of squamous cell carcinoma of the head and neck (SCCHN) (dominant model CT + TT vs. CC: OR = 1.51, 95% CI = 1.17–1.94). No significant association was found in other subgroup analyses. This meta-analysis suggested that rs1059234 polymorphism of p21 3′ UTR may be associated with increased SCCHN risk. And larger scale primary studies are required to further evaluate the interaction of p21 3′ UTR rs1059234 polymorphism and cancer risk in specific populations.

The effect of TP53 and P21 gene polymorphisms on papillary thyroid carcinoma susceptibility and clinical/pathological features

“…To the best of our knowledge, there is no study to examine the association between P21 variants and thyroid carcinoma. However, the possible role of the P21 polymorphisms and some cancers has been found previously . Two common polymorphisms of P21 , rs1801270 and rs1059234, were selected for this study.…”

“…It has been shown that C > A substitution in rs1059234 at codon 31 of the P21 protein (nonsynonymous serine‐to‐arginine substitution, p.Ser31Arg) alters DNA binding of zinc finger motif and expression of P21 . Also, the rs1059234 polymorphism, in the 3'untranslated region of P21 affects mRNA stability and alters the level of protein expression and is implicated in the proliferation, differentiation, and tumor inhibition …”

“…However, the possible role of the P21 polymorphisms and some cancers has been found previously. 19,20 Two common polymorphisms of P21, rs1801270 and rs1059234, were selected for this study. It has been shown that C > A substitution in rs1059234 at codon 31 of the P21 protein (nonsynonymous serine-toarginine substitution, p.Ser31Arg) alters DNA binding of zinc finger motif and expression of P21.…”

“…21 Also, the rs1059234 polymorphism, in the 3'untranslated region of P21 affects mRNA stability and alters the level of protein expression and is implicated in the proliferation, differentiation, and tumor inhibition. 19 In this study, we analyzed TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms in southeast Iranian PTC patients and control group. Moreover, we investigated the effect of these polymorphisms on pathological and clinical characteristics of PTC.…”

MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

“…miRNAs’ target site polymorphisms may potentially play a role in the interaction between miRNAs and their target mRNA, which is dependent on the effect of polymorphism on miRNA:mRNA interactions. There was also a meta‐analysis on 3'UTR polymorphisms and the risk of cancers, but the results were only for two polymorphisms and were not specific for CRC or miRNA‐binding sites. To the best of our knowledge, there is no previous systematic review on the association between miRNA‐binding site polymorphisms and CRC.…”