Association of PAI-1 4G/5G and -844G/A Gene Polymorphism and Changes in PAI-1/tPA Levels in Stroke: A Case-Control Study

Saidi, Sarra; Slamia, L. Ben; Mahjoub, Touhami; Ammou, Sofyan B.; Almawi, Wassim Y.

doi:10.1016/j.jstrokecerebrovasdis.2007.02.002

Cited by 37 publications

(20 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study in China showed a 2.1-fold significantly increased risk of ischemic stroke in Apo ε4 carriers [53] . These results were replicated in a Tunisia study [51,54] , where Apo ε4 was found to be higher in the stroke patients (0.370 vs 0.181; P<0.001). Furthermore, there have been reports on the role of the ε4 allele as a prognostic genetic marker for the atherothrombotic subtype, lacunar infarcts [55] and carotid plaques [56] .…”

Section: Lipid Metabolismmentioning

confidence: 54%

“…However, epidemiological data on the role of the PAI-1 4G/5G polymorphism in ischemic stroke are still controversial, with some studies [49] finding that 4G/4G confers an increased risk of stroke and others finding no association [50] . Another group demonstrated a protective effect of the 4G allele against ischemic stroke (OR=0.176), which may be through a mechanism unrelated to fibrinolysis, and instead involves altered plaque stabilization and/or antagonism of tissue-type plasminogen activator (tPA) effects [51] .…”

Section: Hemostatic Systemmentioning

confidence: 99%

See 1 more Smart Citation

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

View full text Add to dashboard Cite

Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.

show abstract

Section: Lipid Metabolismmentioning

confidence: 54%

Section: Hemostatic Systemmentioning

confidence: 99%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

View full text Add to dashboard Cite

show abstract

“…Polymorphisms which have been presented below may be the cause of inherited thrombophilia and may result in pregnancy loss. The hypothesis is based on a number of cardiology studies which have confirmed the involvement of these polymorphisms in thrombotic incidents [11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

Barlik

Seremak‐Mrozikiewicz²,

Drews³

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

show abstract

“…Pronounced elevations of PAI-1 antigen levels were seen in 4G carriers of −675 4G/5G polymorphism of T2D patients in a large number of studies, [4] as Open Journal of Endocrine and Metabolic Diseases well as non-diabetic and in different ethnic populations like Tunisians [27] [28] [29].…”

Section: Resultsmentioning

confidence: 99%

Genetic and Metabolic Determinants of Plasminogen Activator Inhibitor 1 (PAI-1) in Tunisian Type 2 Diabetes Patients

Moustapha¹,

Chadhli-Chaieb²,

Mahjoub³

et al. 2017

OJEMD

Self Cite

View full text Add to dashboard Cite

Background: PAI-1 (plasminogen activator inhibitor-1) is a powerful regulator of fibrinolysis and plasma level is high in type 2 diabetes and cardio-vascular disease, which is determined by genetic polymorphisms in PAI-1 gene and environmental factors. The aim of the study was to examine the determinants of plasma PAI-1 Ag level among type 2 diabetes patients. Methods: 491 Tunisian type 2 diabetes patients had clinical evaluation (weight, high, BMI, Waist Circumference), laboratory investigations including FBG Hb1Ac, cholesterol, triglyceride; HDL-cholesterol was done; plasma PAI-1 antigen level was done with ELISA; −675 4G/5G and −844 G/A polymorphisms of PAI-1 gene was done by PCR-ASA and PCR-RFLP respectively. Results: The mean age for our patients was 58.3 ± 10.5 years; sex-ratio = 0.92; mean PAI-1 level was 34.6 ± 21.3 ng/ml. We didn't find correlation between PAI-1 level and BMI, but we have found significant correlation between PAI-1 and waist circumference (p = 0.032), most enhanced in men (P = 0.002), T2D patients who have FBG > 11 mmol/l had PAI-1 Ag level higher than those who have FBG < 11 mmol/l (P = 0.034), but no difference found between T2D with high Hb1Ac > 8% and those with Hb1Ac < 8%, significant correlation was seen between PAI-1 level and LDL-cholesterol (P = 0.05), high correlation between PAI-1 Ag level and −675 4G/5G polymorphism genotype was seen, 4G/4G carriers had the highest PAI-1 level, 4G/5G had intermediary level and 5G/5G had the lowest level (P < 0.001). No correlation was seen between PAI-1 Ag level and −844G/A polymorphism genotypes. Using multiple variable linear regression analysis, the independent factor associated with plasma PAI-1 level was −675 4G/5G polymorphism (regression coefficient β = 4.6, P

show abstract

Association of PAI-1 4G/5G and -844G/A Gene Polymorphism and Changes in PAI-1/tPA Levels in Stroke: A Case-Control Study

Cited by 37 publications

References 38 publications

Genetics of stroke

Genetics of stroke

Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

Genetic and Metabolic Determinants of Plasminogen Activator Inhibitor 1 (PAI-1) in Tunisian Type 2 Diabetes Patients

Contact Info

Product

Resources

About