Association of Papacarie Duo® and low-level laser in antimicrobial photodynamic therapy (aPDT)

Mendes, Roberta Janaina Soares; de Sousa, Nayanna Matos; Furtado, Guilherme Silva; Paschoal, Marco Aurélio Benini; Lago, Andréa Dias Neves

doi:10.1007/s10103-024-03981-9

Cited by 1 publication

(1 citation statement)

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“…However, there has been a considerable surge in exploring adjunctive treatments, and one such innovative method gaining traction is low-level laser-activated photodynamic therapy utilizing methylene blue (MB) ( 5 ). Low-level laser treatment promotes the proliferation of adenosine triphosphate at the mitochondrial level ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

Karuppan Perumal,

Rajan Renuka,

Manickam Natarajan

2024

Front. Oral. Health

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Chronic periodontitis is a ubiquitous inflammatory disease in dental healthcare that is challenging to treat due to its impact on bone and tooth loss. Conventional mechanical debridement has been challenging in eliminating complex subgingival biofilms. Hence, adjunctive approaches like low-level laser antimicrobial photodynamic therapy (A-PDT) utilising methylene blue (MB) have been emerging approaches in recent times. This review evaluates the latest research on the use of MB-mediated A-PDT to decrease microbial count and enhance clinical results in chronic periodontitis. Studies have shown the interaction between laser light and MB generates a phototoxic effect thereby, eliminating pathogenic bacteria within periodontal pockets. Moreover, numerous clinical trials have shown that A-PDT using MB can reduce probing depths, improve clinical attachment levels, and decrease bleeding during probing in comparison to traditional treatment approaches. Notably, A-PDT shows superior antibiotic resistance compared to conventional antibiotic treatments. In conclusion, the A-PDT using MB shows promise as an adjunctive treatment for chronic periodontitis. Additional research is required to standardize treatment protocols and assess long-term outcomes of A-PDT with MB in the treatment of periodontitis.

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Section: Introductionmentioning

confidence: 99%