Association of Parental History of Stroke With Clinical Parameters in Patients With Ischemic Stroke or Transient Ischemic Attack

Tentschert, S.; Greisenegger, Stefan; Wimmer, Romana; Lang, Wilfried; Lalouschek, Wolfgang

doi:10.1161/01.str.0000087361.60511.e7

Cited by 12 publications

(16 citation statements)

References 30 publications

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“…The aggregation of the risk factors hypertension and diabetes mellitus themselves in some families (from parents to probands) also indicates a heritability of stroke risk factors. Our finding of a stronger familial relationship when inherited from mothers is in agreement with previous reports [7, 8]. The reasons for this gender effect remain to be elucidated.…”

Section: Discussionsupporting

confidence: 93%

“…Recent studies indicate that there may also be a genetic influence on more common stroke types [4,5,6]. There may be gender-dependent factors with a stronger hereditary disposition among females [7, 8], and heritability of stroke also seems to be associated with age at stroke onset [2, 9]. Thus, it is of interest to further identify and investigate the genetic factors that influence stroke risk with more detailed descriptions on an individual basis of large groups of first-degree relatives of stroke patients and control subjects.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Stroke and Vascular Risk Factors among First-Degree Relatives of Stroke Patients and Control Subjects

Lindgren¹,

Lövkvist²,

Hallström³

et al. 2005

Cerebrovasc Dis

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Background: Genetic and environmental factors may be of importance for stroke risk. We assessed the prevalence of stroke and vascular risk factors among first-degree relatives and spouses of stroke patients and control subjects. Methods: As a part of the Lund Stroke Register study, we asked 925 consecutive patients with first-ever stroke and 286 control subjects to complete a questionnaire about all their first-degree relatives and spouses. The questionnaires addressed whether these relatives had been affected by stroke or TIA, hypertension, heart disease, diabetes mellitus, and if they were smokers. Results: A total of 606 patients and 261 control subjects returned the questionnaire, providing information on 4,972 first-degree relatives and 738 spouses. The prevalence of stroke or TIA was 12.3% among first-degree relatives of patients and 7.5% among first-degree relatives of control subjects (OR 1.74, 95% CI 1.36–2.22). Corresponding results for hypertension were 21.0 and 16.7% (OR 1.33, 95% CI 1.10–1.60). The prevalences of heart disease, diabetes mellitus and smoking did not differ significantly between first-degree relatives of patients and control subjects. Spouses of patients and control subjects had similar prevalences of stroke or TIA and vascular risk factors. Conclusions: The prevalences of stroke or TIA and hypertension are higher among first-degree relatives of stroke patients than among first-degree relatives of control subjects. This, and the lack of differences between spouses of patients and control subjects, indicates that an increased risk of stroke may in part be explained by heritability of hypertension.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Prevalence of Stroke and Vascular Risk Factors among First-Degree Relatives of Stroke Patients and Control Subjects

Lindgren¹,

Lövkvist²,

Hallström³

et al. 2005

Cerebrovasc Dis

View full text Add to dashboard Cite

show abstract

“…Sex-specific differences with respect to paternal of maternal history of stroke and stroke risk in male or female offspring were indicated in a previous study. 15 Information was not available from the relatives for the covariates of the age, body mass index, smoking status, drinking status, and habitation area. Since the proband's age was highly likely to correlate with the relative's age, age-adjustment based only on proband's age indeed seems to be warranted.…”

Section: Discussionmentioning

confidence: 99%

Familial aggregation and coaggregation of history of hypertension and stroke

et al. 2004

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We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

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“…Further evidence for a causal connection between HTN and heritability of stroke comes from several studies which we could not include in the systematic review because of their differing methodology; Tentschert et al [67] showed a relationship between maternal history of stroke and prevalence of HTN and left ventricular hypertrophy in female stroke patients. Nicolaou et al [68] found a higher occurrence of stroke in parents of hypertensive probands compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, Lestro-Henriques et al [69] found that an FHx of cardiac or cerebrovascular disease was more common in hypertensive stroke patients compared with normotensive stroke patients. Furthermore, the majority of case-control and prospective cohort studies that investigated a possible interaction between FHx stroke and HTN found a significant association and reported that adjustment for HTN diminished the associations between an FHx and stroke [30,32,33,34, 37, 39, 43, 44, 46, 49, 67,70,71,72]. Most studies however revealed a familial component to stroke that was independent of HTN [27, 30, 31, 68, 70,72,73,74,75] suggesting that factors other than HTN contribute to the heritability of stroke.…”

Section: Discussionmentioning

confidence: 99%

Potential Confounding by Intermediate Phenotypes in Studies of the Genetics of Ischaemic Stroke

Floßmann

Schulz²,

Rothwell³

2005

Cerebrovasc Dis

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Background: Family history (FHx) of stroke is perceived to be an important risk factor for ischaemic stroke. However, there are several intermediate phenotypes that are often involved in the aetiology of ischaemic stroke and that have a substantial genetic component themselves. We studied FHx of ischaemic heart disease (IHD), hypertension (HTN) and diabetes mellitus (DM) as risk factors for ischaemic stroke. Methods: We performed a systematic review of case-control and cohort studies reporting on FHx_IHD, FHx_HTN or FHx_DM as risk factors for stroke using bibliographic databases, and by hand searching reference lists and journals. Odds ratios of FHx as a risk factor for stroke were calculated within individual studies. We included unpublished data from two Oxfordshire population-based studies to assess effects on subtypes of ischaemic stroke. Results: We identified 54 studies that investigated the odds of stroke conferred by a positive FHx, 24 of which reported data on FHx of one or more intermediate phenotypes in addition to FHx of stroke. Most studies reported an increased frequency of FHx_IHD and FHx_HTN in stroke patients versus controls. The association was significant in 6 out of 14 studies for FHx_IHD and 4 out of 11 studies for FHx_HTN. In contrast, FHx_DM was not associated with stroke. FHx_IHD was particularly associated with large vessel strokes (OR 1.72, CI 1.3–2.2, p = 0.00004). Conclusions: FHx_IHD and FHx_HTN are both risk factors for stroke. It is likely that the apparent heritability of stroke is partly accounted for by heritability of HTN and large vessel atherosclerosis. Analyses of heritability of stroke and candidate gene studies should be adjusted accordingly.

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Association of Parental History of Stroke With Clinical Parameters in Patients With Ischemic Stroke or Transient Ischemic Attack

Cited by 12 publications

References 30 publications

Prevalence of Stroke and Vascular Risk Factors among First-Degree Relatives of Stroke Patients and Control Subjects

Prevalence of Stroke and Vascular Risk Factors among First-Degree Relatives of Stroke Patients and Control Subjects

Familial aggregation and coaggregation of history of hypertension and stroke

Potential Confounding by Intermediate Phenotypes in Studies of the Genetics of Ischaemic Stroke

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