Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Chen, Ruixue; Chen, Lifen; Liu, Yifeng; Wang, Feixia; Wang, Siwen; Huang, Yun; Hu, Kai-Lun; Fan, Yuzhi; Liu, Ruoyan; Zhang, Runjv; Zhang, Dan

doi:10.1186/s12884-021-04261-y

Cited by 8 publications

(6 citation statements)

References 60 publications

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“…The results of previous studies showed that higher parents educated, and lower BMI ( Vejrup et al, 2022 ). Couples with BMI ≥25 kg/m 2 had higher odds of LGA than those with BMI <25 kg/m 2 ( Chen R. et al, 2021 ). In our study, we found a significant negative causal association between BMI and EA, and for male, BMI shows a more significant positive effect on offspring BW than male EA in the result of multivariable MR.…”

Section: Discussionmentioning

confidence: 99%

Educational attainment and offspring birth weight: A bidirectional Mendelian randomization study

Liu

Chen²,

Ni³

et al. 2022

Front. Genet.

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Background: The association between educational attainment (EA) and offspring birth weight (BW) has been reported by several traditional epidemiological studies. However, evidence for this association tends to be mixed and confounded. This study aimed to investigate the causal association between EA of parents and offspring BW.Methods: Here, we carried out a two-sample bidirectional Mendelian randomization (MR) analysis to examine the causal association between EA of males (n = 131,695) and females (n = 162,028) and offspring BW using genetic instruments. Summary statistics of EA associated single nucleotide polymorphisms (SNPs) were extracted from a GWAS incorporating 293,723 individuals of European descent performed by the Social Science Genetic Association Consortium (SSGAC), and the effects of these SNPs on offspring BW were estimated using a GWAS meta-analysis of 86,577 participants of European descent from 25 studies. Univariable MR analyses were conducted using the inverse-variance weighted (IVW) method and four other methods. Further sensitivity analyses were carried out to test the viability of the results. Multivariable MR was used to examine the confounders between the exposure and outcome.Results: The result shows evidence that the offspring BW is positively causally affected by female EA. Each one standard deviation (SD) increase in female EA was associated with 0.24 SD higher of offspring BW (95% confidence interval [CI], 0.10 to 0.37, p < 0.001 for the IVW method). Similarly, change in offspring BW was 0.21 SD (95% CI: 0.07 to 0.34, p = 2.82 × 10–3) per one SD higher in male EA. No causal effect of BW on EA was found by any of the five methods. The causal association between female EA and offspring BW maintained after adjusting for alcoholic drinks per week and BMI. The effect of male EA on offspring BW was attenuated when we adjusted for BMI and alcoholic drinks per week using multivariable MR analysis.Conclusion: Our study indicated that female EA is positively causally associated with offspring BW. The association between male EA and offspring BW may be confounded by alcoholic drinks per week and BMI.

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Section: Discussionmentioning

confidence: 99%

Educational attainment and offspring birth weight: A bidirectional Mendelian randomization study

Liu

Chen²,

Ni³

et al. 2022

Front. Genet.

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“…Patients were considered eligible if they met the following criteria: [1] <35 years of age; [2] undergoing FET cycles and having alive singleton birth ≥28 weeks. Exclusion criteria were [1] multiple pregnancies, vanishing twins and still birth; [2] Cycles with oocyte donation; [3] preimplantation genetic testing cycles; [4] congenital uterine malformations or acquired uterine diseases (untreated endometrial polyps, submucosal fibroids, intrauterine adhesions); [5] women with chronic hypertension. In addition, if more than one delivery for the same women was in the electronic database, only the first pregnancy was included for analysis.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…On the one hand, some studies have shown that subfertility itself is the main reason for the adverse perinatal outcomes (3,4). On the other hand, growing evidence suggested that both ART procedures and embryo manipulation in the laboratory may play a vital role (5)(6)(7)(8). Furthermore, recent studies reported that endometrial thickness (EMT) could be involved as well.…”

Section: Introductionmentioning

confidence: 99%

Endometrial thickness is associated with low birthweight in frozen embryo transfer cycles: A retrospective cohort study of 8,235 singleton newborns

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the association between endometrial thickness (EMT) and adverse neonatal outcomes in frozen in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles.MethodsThis retrospective study involved a total of 8,235 women under the age of 35 years who underwent IVF/ICSI cycles and received frozen embryo transfer (FET) at a tertiary-care academic medical from January 2015 to December 2019, resulting in a live singleton newborn. Patients were categorized into three groups depending on EMT: ≤7.5 mm, 7.5-12 mm and >12 mm. The primary outcome was low birthweight (LBW). The secondary outcomes were preterm birth (PTB), small-for-gestational age (SGA), large-for-gestational age (LGA) and high birthweight (HBW).Result(s)Compared with EMT >7.5–12 mm group, the risk of being born LBW was statistically significantly increased in the EMT ≤7.5 mm group (adjusted odds ratio [aOR] 2.179; 95% confidence interval [CI], 1.305–3.640; P=.003), while dramatically decreased in the EMT >12 mm group (aOR 0.584; 95% CI, 0.403-0.844; P=.004). Moreover, newborn gender and pregnancy complications were all independent predictors for LBW. Furthermore, a significant decrease in birthweight was found in the EMT ≤7.5 mm group as compared with EMT >7.5–12 mm group and EMT >12 mm group (3,239 ± 612 vs. 3,357 ± 512 and 3,374 ± 479 g, respectively), and similar result was found in term of gestational age (38.41 ± 2.19 vs. 39.01 ± 1.68 and 39.09 ± 1.5 weeks, respectively).Conclusion(s)After frozen IVF/ICSI-ET, EMT ≤7.5 mm is independently associated with increased risk of LBW among women with singleton newborns. Therefore, we suggest that women with EMT ≤7.5 mm after achieving pregnancy by IVF/ICSI-ET treatment should warrant more attention to reduce the risk of delivering a LBW newborn.

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“…However, the incidence of the diseases are still high, suggesting that we still need to pay attention to other causes, such as father related factors. Paternal obesity has been reported to increase the risk of preeclampsia, SGA, birth defects and preterm birth (19,(26)(27)(28)(29). According to the study results of He et al, compared with the pre-pregnancy normal weight, the corresponding ORs for paternal overweight and obesity were: preterm birth (1.12; 1.10-1.14 vs. 1.24; 1.20-1.28), low birth weight (1.10; 1.05-1.15 vs. 1.29; 1.20-1.40), which was consistent with our results (29).…”

Section: Discussionmentioning

confidence: 99%

Association between paternal pre-pregnancy body mass index with preterm birth and low birth weight

Sun

Zhang²,

Chen³

et al. 2022

Front. Pediatr.

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BackgroundWith the current global epidemic of obesity, especially among men, there is a need to understand its impact on adverse pregnancy outcomes. This study aimed to assess whether paternal pre-pregnancy body mass index (BMI) was associated with preterm birth and low birth weight in offspring.MethodsMultinomial logistic regression model was used to analyze associations between paternal BMI and preterm birth and low birth weight in different subgroups, the final model was adjusted for confounding factors of mothers and fathers. Further subgroup analysis was conducted to explore the stability of the risk associations.ResultsA total of 34,104 participants were included in this study, including 1,442 (4.2%) underweight, 13,930 (40.9%) overweight and 5,008 (14.7%) obese according to paternal BMI. The total incidence of preterm birth was 11.85% (4041/34104), and the incidence of low birth weight was 8.86% (3020/34104). In the total study population, compared with normal weight men, paternal pre-pregnancy overweight or obese was associated with a significantly increased risk of preterm birth [aOR; 95% CI respectively (1.34; 1.25–1.45 vs. 1.26; 1.14–1.40)] and low birth weight [aOR; 95% CI respectively (1.60; 1.46–1.74 vs. 1.40; 1.25–1.58)] in offspring. The results of subgroup analysis showed that the direction of the risk association was consistent, indicating good stability.ConclusionPaternal pre-pregnancy overweight and obesity were associated with an increased risk of preterm birth and low birth weight in their offspring.

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Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Cited by 8 publications

References 60 publications

Educational attainment and offspring birth weight: A bidirectional Mendelian randomization study

Educational attainment and offspring birth weight: A bidirectional Mendelian randomization study

Endometrial thickness is associated with low birthweight in frozen embryo transfer cycles: A retrospective cohort study of 8,235 singleton newborns

Association between paternal pre-pregnancy body mass index with preterm birth and low birth weight

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