Association of PARL Gene Rs3732581, Rs73887537 Polymorphisms with Type 2 Diabetes Mellitus, Insulin Resistance and Blood Lipid Levels in Chinese Population

Abstract

Aim: The aim of the current study was to investigate the associations between rs3732581, rs73887537 of PARL gene with type 2 diabetes mellitus and its related phenotypes in Chinese T2DM case-control population. Methods:We genotyped PARL gene rs3732581, rs73887537 polymorphisms in 543 T2DM patients and 384 healthy controls by using PCR-RFLP technique. Plasma glucose, insulin and lipid were measured by biochemical technique.Results: rs73887537 polymorphism of PARL gene was not existed in the studied population. The genotype and allele distributions of rs3732581 polymorphism were not significantly different between T2DM and control groups (both P>0.05). However compared with carriers of C allele, the carriers of the GG genotype showed significantly higher levels of triglyceride, total cholesterol in the T2DM and control groups respectively.Conclusion: rs73887537 polymorphism of PARL gene was not existed in the Chinese studied population. The rs3732581 polymorphism of PARL gene is not associated with the presence of T2DM. However, it is associated with blood lipid levels in T2DM and healthy Chinese population differently.