Association of Pectus Excavatum With Ventricular Remodelling and Mitral Valve Abnormalities in Marfan Syndrome

Hashem, Dalia Abdulmonem L; Chan, Vny; Hanneman, Kate; Wald, Rachel M.; Thavendiranathan, Paaladinesh; Ouzounian, Maral; Oechslin, Erwin; Karur, Gauri Rani

doi:10.1177/08465371221127236

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…1). Twenty-five studies 22,24,34–56 totaling 2800 patients (mean age 27.9 ± 13.9 years, 48.2% females) affected by the most common TSA (PE, PC, scoliosis, SBS, and MS) were thus included in this systematic review. A summary of the included studies’ characteristics is reported in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The relationship between mitral valve prolapse and thoracic skeletal abnormalities in clinical practice: a systematic review

Sonaglioni,

Nicolosi,

Lombardo

2024

Journal of Cardiovascular Medicine

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Background Literature data suggest high inter-study variability in mitral valve prolapse (MVP) prevalence among individuals with thoracic skeletal abnormalities (TSA). This systematic review aimed at estimating the overall prevalence of MVP in individuals with the most common TSA, including not only the oldest studies (before the year 2000) but also the most recent ones (after the year 2000). Methods PubMed and EMBASE databases were systematically reviewed in November 2023. Studies assessing the relationship between MVP and TSA and estimating the MVP prevalence in pectus excavatum (PE), pectus carinatum (PC), scoliosis, straight back syndrome (SBS) and Marfan syndrome (MS) were included. There was no limitation on time periods. Results Twenty-five studies with a total of 2800 patients (27.9 ± 13.9 years, 48.2% females) were analyzed. The highest prevalence of MVP was observed among MS patients (47.3%), while the lowest was detected in PC individuals (23%). Prevalence of MVP was similar among PE (30.8%), scoliosis (26.3%) and SBS (25.5%) patients. When dividing the studies on the basis of temporal period, the average MVP prevalence was approximately two-fold higher in all studies conducted before the year 2000 in comparison with the most recent ones, regardless of TSA type. This discrepancy might be primarily ascribed to relevant differences in the echocardiographic criteria employed for MVP diagnosis before (less specific) and after (more specific) the year 2000, respectively. Conclusions The estimated MVP prevalence in TSA individuals is significantly higher than that observed in the general population. Individuals with TSA should be screened for MVP presence on transthoracic echocardiography.

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Section: Resultsmentioning

confidence: 99%

The relationship between mitral valve prolapse and thoracic skeletal abnormalities in clinical practice: a systematic review

Sonaglioni,

Nicolosi,

Lombardo

2024

Journal of Cardiovascular Medicine

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Canadian radiology: 2024 update

Yao,

Ertl-Wagner,

Dana

et al. 2024

Diagnostic and Interventional Imaging

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Prevalence of Mitral Valve Prolapse Among Individuals with Pectus Excavatum: A Systematic Review and Meta-Analysis

Sonaglioni,

Bruno,

Polymeropoulos

et al. 2024

Diagnostics

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Background: During the last decades, a small number of studies reported a wide range of variability in the estimated prevalence of mitral valve prolapse (MVP) among individuals with pectus excavatum (PE). The present systematic review and meta-analysis has been primarily designed to summarize the main findings of these studies and to estimate the overall prevalence of MVP among PE individuals. Methods: All imaging studies assessing the prevalence of MVP in PE individuals vs. healthy controls, selected from PubMed and EMBASE databases, were included. The risk of bias was assessed by using the National Institutes of Health (NIH) Quality Assessment of Case–Control Studies. Events (presence of MVP) and nonevents (absence of MVP) in PE individuals and control groups were recorded. The main outcome was the measure of odds ratio (OR) for MVP presence pooled with 95% confidence intervals, using a fixed-effects model. Results: The full texts of eight studies with 303 PE patients (mean age 25.7 yrs) and 498 healthy controls (mean age 31 yrs) were analyzed. Three studies assessed MVP prevalence in children and early adolescents, whereas the remaining five studies examined PE adults. The prevalence of MVP in PE individuals and healthy controls was 40.6% and 12.8%, respectively. In the pooled sample, the OR for MVP presence was significantly higher in PE individuals compared to controls (OR = 5.80, 95%CI = 3.83–8.78, Z = 8.30, p < 0.001). Subgroup analysis revealed that MVP prevalence was approximately three-fold higher among PE children and early adolescents compared with PE adults. Overall, high consistency was observed in the pooled effect sizes, due to the low statistical heterogeneity among the included studies (I2 = 22.7%, p = 0.25). Egger’s test for a regression intercept gave a p-value of 0.07, indicating no publication bias. The sensitivity analysis supported the robustness of the results. Conclusions: PE individuals are nearly six times more likely to have MVP than controls. MVP prevalence is three-fold higher in PE individuals during childhood and early adolescence, compared to PE adults. Given the strong association between MVP and PE, MVP should be suspected in all individuals with anterior chest wall deformity.

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Association of Pectus Excavatum With Ventricular Remodelling and Mitral Valve Abnormalities in Marfan Syndrome

Cited by 3 publications

References 37 publications

The relationship between mitral valve prolapse and thoracic skeletal abnormalities in clinical practice: a systematic review

The relationship between mitral valve prolapse and thoracic skeletal abnormalities in clinical practice: a systematic review

Canadian radiology: 2024 update

Prevalence of Mitral Valve Prolapse Among Individuals with Pectus Excavatum: A Systematic Review and Meta-Analysis

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