Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population

Abstract

ObjectivesPeptic ulcer disease (PUD) is a common disorder, but whether an association exists between PUD and anthropometric indicators remains controversial. Furthermore, no studies on the association of PUD with anthropometric indices, blood parameters, and nutritional components have been reported. The aim of this study was to assess associations of anthropometrics, blood parameters, nutritional components, and lifestyle factors with PUD in the Korean population.MethodsData were collected from a nationally representative sample of the South Korean population using the Korea National Health and Nutrition Examination Survey. Logistic regression was used to examine associations of anthropometrics, blood parameters and nutritional components among patients with PUD.ResultsAge was the factor most strongly associated with PUD in women (p = <0.0001, odds ratio (OR) = 0.770 [0.683–0.869]) and men (p = <0.0001, OR = 0.715 [0.616–0.831]). In both crude and adjusted analyses, PUD was highly associated with weight (adjusted p = 0.0008, adjusted OR = 1.251 [95%CI: 1.098–1.426]), hip circumference (adjusted p = 0.005, adjusted OR = 1.198 [1.056–1.360]), and body mass index (adjusted p = 0.0001, adjusted OR = 1.303 [1.139–1.490]) in women and hip circumference (adjusted p = 0.0199, adjusted OR = 1.217 [1.031–1.435]) in men. PUD was significantly associated with intake of fiber (adjusted p = 0.0386, adjusted OR = 1.157 [1.008–1.328], vitamin B2 (adjusted p = 0.0477, adjusted OR = 1.155 [1.001–1.333]), sodium (adjusted p = 0.0154, adjusted OR = 1.191 [1.034–1.372]), calcium (adjusted p = 0.0079, adjusted OR = 1.243 [1.059–1.459]), and ash (adjusted p = 0.0468, adjusted OR = 1.152 [1.002–1.325] in women but not in men. None of the assessed blood parameters were associated with PUD in women, and only triglyceride level was associated with PUD in men (adjusted p = 0.0169, adjusted OR = 1.227 [1.037–1.451]).DiscussionWe found that obesity was associated with PUD in the Korean population; additionally, the association between nutritional components and PUD was greater in women than in men.

A comparative study of subsequent liver cirrhosis risk in non‐Helicobacter pylori‐infected peptic ulcer patients with and without vagotomy: An Asian population cohort study

“…Concern exists as to whether such an association is direct or indirect. For example, obesity is a common risk factor for peptic ulcers and nonalcoholic steatohepatitis . Abdominal surgery for peptic ulcer may affect subsequent development of obesity, indicating that this association might be only an epiphenomenon of confounding factors such as obesity.…”

“…For example, obesity is a common risk factor for peptic ulcers and nonalcoholic steatohepatitis. 39 Abdominal surgery for peptic ulcer may affect subsequent development of obesity, indicating that this association might be only an epiphenomenon of confounding factors such as obesity. Nevertheless, if surgery itself played a role, the result should be similar either in truncal vagotomy or in simple closure.…”

Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study

“…The complex and multifactorial pathogenesis of PUD is related to various risk factors [1][2][3]. An imbalance of gastric luminal factors and disruption of the barrier function of the mucosa are involved in the pathogenesis of PUD [1,3].…”

“…The complex and multifactorial pathogenesis of PUD is related to various risk factors [1][2][3]. An imbalance of gastric luminal factors and disruption of the barrier function of the mucosa are involved in the pathogenesis of PUD [1,3]. Diverse environmental factors-including Helicobacter pylori infection, smoking, excessive alcohol consumption, and a variety of drugs-are ulcerogenic [1,[3][4][5].…”

Rabeprazole in the treatment of duodenal ulcer desease and functional dyspepsia

“…Риск развития ЯБ двенадцатиперстной кишки повы-шают такие особенности образа жизни, как питание с недостаточным содержанием витаминов, микроэлемен-тов, пищевых волокон, кальция, витаминов А и группы В, высоким потреблением рафинированных продуктов, не обладающих необходимой буферной емкостью; низкая физическая активность и неполноценный сон [16,17].…”