Association of perceived neighborhood characteristics, socioeconomic status and rural residency with health outcomes in <scp>E</scp>gyptian patients with systemic lupus erythematosus: one center study

Abdul-Sattar, Amal; Magd, Sahar Abou El

doi:10.1111/1756-185x.12331

Cited by 11 publications

(13 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A single center cross-sectional study on 80 Egyptian patients with aSLE supported the finding that poor socioeconomic status and rural residency are associated with lower SF-36 physical functioning and higher disease activity. 39 Other studies from Egypt, that have been done on patients from the free-of-charge tertiary university hospitals showed similar results to our cohort. Renal manifestations were found in 67% and 72.2% of patients with cSLE in two previous studies from Cairo University hospitals respectively 40 , 41 and 72.5% in a smaller study from other tertiary university hospitals in Cairo (Ain Shams University Hospitals).…”

Section: Discussionsupporting

confidence: 90%

A comparative study between the disease characteristics in adult-onset and childhood-onset systemic lupus erythematosus in Egyptian patients attending a large university hospital

El-Garf

Gheith

et al. 2020

Lupus

View full text Add to dashboard Cite

Introduction Disease features and laboratory abnormalities differ among adult-onset and childhood-onset systemic lupus erythematosus (aSLE and cSLE). Socioeconomic status both independent of, and in combination with, ethnicity influences the disease phenotype and outcome. Objective To compare the various disease features among patients with cSLE and aSLE in a limited monetary income Egyptian cohort attending a large free-of-charge university hospital. Patients and methods: Retrospective analysis of the medical records of 714 SLE patients attending Cairo University Hospitals from January 2000 to December 2019. Of them 602 (400 with aSLE and 202 with cSLE) were enrolled in the study. Results The mean age of disease onset was 28.27 ± 10.55 among aSLE patients compared to 12.88 ± 4.26 years among cSLE patients. Disease duration was 12.03 ± 5.05 and 4.14 ± 3.18 years in aSLE and cSLE, respectively. Female to male ratio was 15:1 among patients with aSLE, as compared to 2.67:1 among cSLE (<0.001). Arthritis (69%), oral ulcers (48.5%), neuropsychiatric (18.3%) and thrombotic manifestations of antiphospholipid syndrome (12%) were significantly more frequent in aSLE. On the other hand, renal (67.8%), serositis (49.6%), fever (49%), lymphopenia (40.6%), hemolytic anemia (38.6%), and discoid lupus (13.4%) were significantly more frequent in cSLE. Weight loss, malar rash, photosensitivity, thrombocytopenia, leucopenia and lymphadenopathy were not significantly different between the two groups. Hypocomplementemia, proteinuria, urinary sediments, hematuria were significantly more frequent in cSLE. For those patients with renal involvement, who underwent renal biopsy (58.3% in aSLE and 63.5% in cSLE), there was no significant difference with regard to the different histopathological classes. Anti-Smith, anti-cardiolipin antibodies and rheumatoid factor were significantly more frequent among aSLE patients, while anti-La antibodies were more frequent among cSLE patients. Conclusion Arthritis was the most common clinical manifestation over time in aSLE compared to renal involvement in cSLE. Renal disease tends to be more active in cSLE. The differences in disease manifestations between this cohort and other studies can be attributed to the ethnic and socioeconomic disparities.

show abstract

Section: Discussionsupporting

confidence: 90%

A comparative study between the disease characteristics in adult-onset and childhood-onset systemic lupus erythematosus in Egyptian patients attending a large university hospital

El-Garf

Gheith

et al. 2020

Lupus

View full text Add to dashboard Cite

show abstract

“…This association was present even though the patients with low education were on average older at the onset of their SLE (so education would have been completed years before SLE onset for the vast majority). Previous studies demonstrated a link between low SES and worse SLE patient outcomes in disease activity, disease damage, mortality, and quality of life . However, most studies were from health care systems that did not have universal coverage that could marginalize those with low education .…”

Section: Discussionmentioning

confidence: 99%

“…Others have reported that childhood SES influences adult health, independent of SES as an adult . In previous studies of SES influencing SLE, disease activity was measured using different assessment tools: SLEDAI , SLAM , and Systemic Lupus Activity Questionnaire . We used both SLEDAI‐2K and SLAM, but only SLEDAI‐2K was affected by low education.…”

Section: Discussionmentioning

confidence: 99%

Influence of Education on Disease Activity and Damage in Systemic Lupus Erythematosus: Data From the 1000 Canadian Faces of Lupus

George

Wong-Pak

Peschken

et al. 2016

Arthritis Care & Research

View full text Add to dashboard Cite

Objective To determine whether socioeconomic status assessed by education is associated with disease activity and the risk of organ damage in systemic lupus erythematosus (SLE). Methods Data from the 1000 Canadian Faces of Lupus, a multicenter database of adult SLE patients, was used to compare education as either low (did not complete high school) or high (completed high school or further) for disease activity and damage. Education was also studied as a continuous variable. The relationships between education and SLE outcomes (any organ damage defined as a Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI] score ≥1, serious organ damage [SDI score ≥3], and end‐stage renal disease) were evaluated using logistic regression analyses adjusted for age, sex, race/ethnicity, and disease duration. Results A total of 562 SLE patients met inclusion criteria (mean age 47 years, 91% female, and mean disease duration of 10 years); 81% had high education. The low education group was twice as likely to be work disabled (30%; P < 0.0001); they had higher disease activity and reduced renal function. Linear regression analysis revealed that low education was significantly associated with higher disease activity at enrollment into the 1000 Canadian Faces of Lupus database, after adjustment for age (at entry and at diagnosis), race/ethnicity, and sex (B 1.255 + 0.507 [SE], β = 0.115, P = 0.014). In our adjusted logistic regression models we were unable to demonstrate significant associations between education and SLE damage. Results did not change when varying the education variable. Conclusion In this cohort, low education was associated cross‐sectionally with higher disease activity and work disability, but not damage.

show abstract

“…Low SES is associated with depression . Specifically, access to less effective treatment and medications within low SES and less developed countries is related to worse outcomes overall.…”

Section: Discussionmentioning

confidence: 99%

Role of psychosocial reserve capacity in anxiety and depression in patients with systemic lupus erythematosus

et al. 2017

View full text Add to dashboard Cite

Reduced psychosocial reserve capacity in individuals leads to vulnerabilities that may ultimately result in greater disease burden and psychological distress. Low self-esteem, optimism, coping and social support were associated with depression and low self-esteem was associated with anxiety for both groups. Despite the Filipino cohort's lower reserve capacity and SES, Filipino patients exhibited less depression than their SoCal counterparts, suggesting that other factors may protect them from experiencing depression.

show abstract

Association of perceived neighborhood characteristics, socioeconomic status and rural residency with health outcomes in Egyptian patients with systemic lupus erythematosus: one center study

Cited by 11 publications

References 41 publications

A comparative study between the disease characteristics in adult-onset and childhood-onset systemic lupus erythematosus in Egyptian patients attending a large university hospital

A comparative study between the disease characteristics in adult-onset and childhood-onset systemic lupus erythematosus in Egyptian patients attending a large university hospital

Influence of Education on Disease Activity and Damage in Systemic Lupus Erythematosus: Data From the 1000 Canadian Faces of Lupus

Role of psychosocial reserve capacity in anxiety and depression in patients with systemic lupus erythematosus

Contact Info

Product

Resources

About