Association of periodontitis with lipid profile: an updated systematic review and meta-analysis

Mirzaei, Ahmadreza; Shahrestanaki, Ehsan; Malmir, Hanieh; Ejtahed, Hanieh‐Sadat; Tajbakhsh, Doreen; Seif, Ehsan; Djalalinia, Shirin; Mahdavi-Gorabi, Armita; Qorbani, Mostafa

doi:10.1007/s40200-022-01071-7

Cited by 5 publications

(5 citation statements)

References 66 publications

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“…In addition, associations between obesity, hypertension, and dyslipidemia have also been reported with periodontal diseases (31,(41)(42)(43)(44). On the other hand, improvement in systemic blood pressure and lipid levels is expected with periodontal treatment (30,31).…”

Section: Discussionmentioning

confidence: 98%

“…A large number of studies have reported significant associations between most of the health factors and health behavior indicators in LS7 or LE8 and periodontitis individually, such as blood glucose (29), blood pressure (30), lipids (31), BMI (32), nicotine exposure (32,33), and diet (34). However, to our knowledge, no study has evaluated the association between LS7 or LE8 as independent factors and periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, poorly controlled diabetes can lead to elevated levels of IL1-β, TNF-α, IL-6, RANKL/OPG, and oxygen metabolites in the gingiva, which can contribute to the destruction of periodontal tissues (40). In addition, associations between obesity, hypertension, and dyslipidemia have also been reported with periodontal diseases (31,(41)(42)(43)(44). On the other hand, improvement in systemic blood pressure and lipid levels is expected with periodontal treatment (30,31).…”

Section: Discussionmentioning

confidence: 99%

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Association between life’s essential 8 and periodontitis: a study based on NHANES 2009–2014

Hou,

Zhang,

Song

et al. 2024

Front. Med.

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BackgroundThis research aims to investigate the relationship between Life’s Essentials 8 (LE8), the American Heart Association’s latest indicator, and periodontitis. The purpose is to provide guidance on preventative measures.MethodsData for our investigation were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014, with a total of 8,784 participants eligible. LE8 scores were compiled from 8 index scores (the score for each component of diet, physical activity, nicotine exposure, sleep duration, body mass index, blood lipids, blood glucose, and blood pressure). Periodontitis was classified by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP). The study utilized multivariable logistic analyses to investigate the potential correlation.ResultsAfter controlling for all covariates, LE8 was discovered to have a significant negative correlation with periodontitis prevalence [0.91 (0.88, 0.94)]. This trend continued to hold statistical significance even after converting LE8 into a categorical variable. Furthermore, a noteworthy adverse correlation was discovered across both genders, specifically males [0.35 (0.22, 0.55)] and females [0.39 (0.25, 0.60)], as well as for the majority of categorical classifications, namely ethnicity, age, education level, and marital status. However, only the age subgroups displayed some degree of significant difference from each other.ConclusionLife’s essential 8 was negatively associated with periodontitis, but more prospective trails are needed to confirm our findings.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between life’s essential 8 and periodontitis: a study based on NHANES 2009–2014

Hou,

Zhang,

Song

et al. 2024

Front. Med.

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“…On the contrary, a systematic review found no associations between morbidity associated with periodontitis and the onset of ischemic cardiac disease (hazard ratio [HR]: 1.14, 95% CI: 0.96–1.36) [ 20 ]. In a meta-analysis, a random effects model showed that PD increased the odds of dyslipidemia by 15% (OR = 1.15, 95% CI: 1.04–1.26), suggesting that periodontitis is associated with an increased risk of dyslipidemia [ 21 ]. These findings were supported by an investigation of the association between the severity of periodontitis and dyslipidemia, which reported a higher prevalence of dyslipidemia in moderate and severe periodontitis compared with non-periodontitis [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the mutual association between periodontitis and DM, numerous studies have been conducted [ 26 , 27 , 28 ]. In a recent study, a multivariable-adjusted model demonstrated that the presence (vs. absence) of periodontitis was associated with a 66% increased risk of diabetes (OR = 1.66, 95% CI: 1.43–1.94); in addition, the risk of diabetes was much higher among those with severe (OR = 2.31, 95% CI: 1.72–3.11) compared with moderate periodontitis (OR =1.54, 95% CI: 1.30–1.82) [ 21 ]. A meta-analysis demonstrated that the risk of DM showed a gradient increase by severity of periodontitis (moderate relative risk [RR] = 1.20, 95% CI: 1.11–1.31; severe RR = 1.34, 95% CI: 1.10–1.63) [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Nutritional Factors to Evaluate Periodontal Clinical Parameters in Patients with Systemic Diseases

et al. 2023

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Nutritional factors reflect the periodontal parameters accompanying periodontal status. In this study, the associations between nutritional factors, blood biochemical items, and clinical parameters were examined in patients with systemic diseases. The study participants were 94 patients with heart disease, dyslipidemia, kidney disease, or diabetes mellitus. Weak negative correlation coefficients were found between nine clinical parameters and ten nutritional factors. Stage, grade, mean probing depth (PD), rate of PD 4–5 mm, rate of PD ≥ 6 mm, mean clinical attachment level (CAL), and the bleeding on probing (BOP) rate were weakly correlated with various nutritional factors. The clinical parameters with coefficients of determinations (R2) > 0.1 were grade, number of teeth, PD, rate of PD 4–5 mm, CAL, and BOP rate. PD was explained by yogurt and cabbage with statistically significant standardized partial regression coefficients (yogurt: −0.2143; cabbage and napa cabbage: −0.2724). The mean CAL was explained by pork, beef, mutton, and dark green vegetables with statistically significant standardized partial regression coefficients (−0.2237 for pork, beef, and mutton; −0.2667 for dark green vegetables). These results raise the possibility that the frequency of intake of various vegetables can be used to evaluate periodontal stabilization in patients with systemic diseases.

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Periodontal disease and occlusive atherosclerotic vascular diseases

Rao,

Rao

2025

Cardiometabolic Diseases

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Association of periodontitis with lipid profile: an updated systematic review and meta-analysis

Cited by 5 publications

References 66 publications

Association between life’s essential 8 and periodontitis: a study based on NHANES 2009–2014

Association between life’s essential 8 and periodontitis: a study based on NHANES 2009–2014

Identification of Nutritional Factors to Evaluate Periodontal Clinical Parameters in Patients with Systemic Diseases

Periodontal disease and occlusive atherosclerotic vascular diseases

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